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Open data
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Basic information
Entry | Database: PDB / ID: 2wxy | ||||||
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Title | Crystal structure of mouse angiotensinogen in the reduced form | ||||||
![]() | ANGIOTENSINOGEN | ||||||
![]() | HORMONE / GLYCOPROTEIN / HYPERTENSION / VASOCONSTRICTOR / RENIN / SERPINS / VASOACTIVE / ANGIOTENSIN | ||||||
Function / homology | ![]() renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure / negative regulation of tissue remodeling / uterine smooth muscle contraction / positive regulation of L-lysine import across plasma membrane / establishment of blood-nerve barrier / positive regulation of L-arginine import across plasma membrane / aldosterone secretion / smooth muscle cell proliferation / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system ...renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure / negative regulation of tissue remodeling / uterine smooth muscle contraction / positive regulation of L-lysine import across plasma membrane / establishment of blood-nerve barrier / positive regulation of L-arginine import across plasma membrane / aldosterone secretion / smooth muscle cell proliferation / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system / ovarian follicle rupture / regulation of transmission of nerve impulse / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / positive regulation of extracellular matrix constituent secretion / vasopressin secretion / Peptide ligand-binding receptors / cell growth involved in cardiac muscle cell development / Metabolism of Angiotensinogen to Angiotensins / operant conditioning / G alpha (q) signalling events / vascular associated smooth muscle cell proliferation / regulation of renal output by angiotensin / regulation of norepinephrine secretion / artery smooth muscle contraction / G alpha (i) signalling events / renin-angiotensin regulation of aldosterone production / angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure / drinking behavior / peristalsis / positive regulation of organ growth / smooth muscle cell differentiation / positive regulation of fatty acid biosynthetic process / positive regulation of blood pressure / vasoconstriction / positive regulation of multicellular organism growth / intracellular sodium ion homeostasis / type 1 angiotensin receptor binding / negative regulation of vascular associated smooth muscle cell proliferation / hormone metabolic process / positive regulation of vascular associated smooth muscle cell migration / organ growth / branching involved in ureteric bud morphogenesis / positive regulation of cardiac muscle hypertrophy / positive regulation of cardiac muscle cell apoptotic process / blood vessel development / associative learning / regulation of calcium ion transport / angiotensin-mediated drinking behavior / negative regulation of angiogenesis / positive regulation of epithelial to mesenchymal transition / stress-activated MAPK cascade / positive regulation of insulin receptor signaling pathway / positive regulation of superoxide anion generation / positive regulation of vascular associated smooth muscle cell proliferation / response to salt stress / ERK1 and ERK2 cascade / astrocyte activation / regulation of heart rate / response to cold / extracellular matrix organization / cell-matrix adhesion / negative regulation of smooth muscle cell proliferation / kidney development / positive regulation of cytokine production / regulation of blood pressure / regulation of long-term neuronal synaptic plasticity / vasodilation / hormone activity / negative regulation of cell growth / positive regulation of neuron projection development / positive regulation of fibroblast proliferation / protein import into nucleus / serine-type endopeptidase inhibitor activity / positive regulation of peptidyl-serine phosphorylation / MAPK cascade / positive regulation of nitric oxide biosynthetic process / regulation of inflammatory response / regulation of gene expression / positive regulation of canonical NF-kappaB signal transduction / positive regulation of cytosolic calcium ion concentration / fibroblast proliferation / neuron apoptotic process / regulation of apoptotic process / negative regulation of neuron apoptotic process / cell population proliferation / positive regulation of MAPK cascade / cell surface receptor signaling pathway / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Zhou, A. / Wei, Z. / Carrell, R.W. / Read, R.J. | ||||||
![]() | ![]() Title: A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Authors: Zhou, A. / Carrell, R.W. / Murphy, M.P. / Wei, Z. / Yan, Y. / Stanley, P.L. / Stein, P.E. / Pipkin, F.B. / Read, R.J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 180.2 KB | Display | ![]() |
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PDB format | ![]() | 143.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 2wxwC ![]() 2wxxC ![]() 2wxzC ![]() 2wy0C ![]() 2wy1C ![]() 2x0bC C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 49606.137 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() | ||||
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#2: Chemical | ChemComp-NA / #3: Chemical | ChemComp-EDO / #4: Water | ChemComp-HOH / | |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.8 Å3/Da / Density % sol: 56 % / Description: NONE |
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Crystal grow | pH: 4.25 / Details: 1.6-2.0M NA2HPO4, PH4.25 |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC CCD / Detector: CCD / Date: Sep 1, 2007 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9763 Å / Relative weight: 1 |
Reflection | Resolution: 2.1→50 Å / Num. obs: 32476 / % possible obs: 91.3 % / Observed criterion σ(I): 2 / Redundancy: 17.4 % / Rmerge(I) obs: 0.07 / Net I/σ(I): 27.9 |
Reflection shell | Resolution: 2.1→2.21 Å / Redundancy: 8.5 % / Rmerge(I) obs: 0.55 / Mean I/σ(I) obs: 3.1 / % possible all: 64.9 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: NONE Resolution: 2.1→48 Å / Cor.coef. Fo:Fc: 0.942 / Cor.coef. Fo:Fc free: 0.933 / SU B: 10.293 / SU ML: 0.122 / Cross valid method: THROUGHOUT / ESU R: 0.218 / ESU R Free: 0.179 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.
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Solvent computation | Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 19.622 Å2
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Refinement step | Cycle: LAST / Resolution: 2.1→48 Å
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