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Basic information
Entry | Database: PDB / ID: 2wxx | ||||||
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Title | Crystal structure of mouse angiotensinogen in the oxidised form | ||||||
![]() | ANGIOTENSINOGEN | ||||||
![]() | HORMONE / GLYCOPROTEIN / HYPERTENSION / VASOCONSTRICTOR / RENIN / SERPINS / VASOACTIVE / ANGIOTENSIN | ||||||
Function / homology | ![]() renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure / negative regulation of tissue remodeling / uterine smooth muscle contraction / positive regulation of L-lysine import across plasma membrane / establishment of blood-nerve barrier / positive regulation of L-arginine import across plasma membrane / aldosterone secretion / smooth muscle cell proliferation / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system ...renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure / negative regulation of tissue remodeling / uterine smooth muscle contraction / positive regulation of L-lysine import across plasma membrane / establishment of blood-nerve barrier / positive regulation of L-arginine import across plasma membrane / aldosterone secretion / smooth muscle cell proliferation / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system / ovarian follicle rupture / regulation of transmission of nerve impulse / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / : / positive regulation of extracellular matrix constituent secretion / vasopressin secretion / Peptide ligand-binding receptors / cell growth involved in cardiac muscle cell development / Metabolism of Angiotensinogen to Angiotensins / operant conditioning / G alpha (q) signalling events / vascular associated smooth muscle cell proliferation / regulation of renal output by angiotensin / regulation of norepinephrine secretion / artery smooth muscle contraction / G alpha (i) signalling events / renin-angiotensin regulation of aldosterone production / angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure / drinking behavior / peristalsis / positive regulation of organ growth / smooth muscle cell differentiation / positive regulation of fatty acid biosynthetic process / positive regulation of blood pressure / positive regulation of multicellular organism growth / vasoconstriction / intracellular sodium ion homeostasis / hormone metabolic process / type 1 angiotensin receptor binding / positive regulation of vascular associated smooth muscle cell migration / organ growth / branching involved in ureteric bud morphogenesis / positive regulation of cardiac muscle hypertrophy / positive regulation of cardiac muscle cell apoptotic process / blood vessel development / negative regulation of vascular associated smooth muscle cell proliferation / associative learning / regulation of calcium ion transport / angiotensin-mediated drinking behavior / positive regulation of epithelial to mesenchymal transition / positive regulation of insulin receptor signaling pathway / stress-activated MAPK cascade / positive regulation of vascular associated smooth muscle cell proliferation / response to salt stress / ERK1 and ERK2 cascade / regulation of heart rate / response to cold / negative regulation of angiogenesis / extracellular matrix organization / cell-matrix adhesion / positive regulation of superoxide anion generation / kidney development / positive regulation of cytokine production / astrocyte activation / negative regulation of smooth muscle cell proliferation / regulation of long-term neuronal synaptic plasticity / serine-type endopeptidase inhibitor activity / hormone activity / negative regulation of cell growth / regulation of blood pressure / positive regulation of neuron projection development / vasodilation / protein import into nucleus / MAPK cascade / positive regulation of nitric oxide biosynthetic process / positive regulation of fibroblast proliferation / positive regulation of peptidyl-serine phosphorylation / positive regulation of cytosolic calcium ion concentration / regulation of inflammatory response / fibroblast proliferation / regulation of gene expression / regulation of apoptotic process / neuron apoptotic process / positive regulation of canonical NF-kappaB signal transduction / negative regulation of neuron apoptotic process / cell population proliferation / positive regulation of MAPK cascade / cell surface receptor signaling pathway / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Zhou, A. / Wei, Z. / Carrell, R.W. / Read, R.J. | ||||||
![]() | ![]() Title: A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Authors: Zhou, A. / Carrell, R.W. / Murphy, M.P. / Wei, Z. / Yan, Y. / Stanley, P.L. / Stein, P.E. / Pipkin, F.B. / Read, R.J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 645.4 KB | Display | ![]() |
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PDB format | ![]() | 559.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 460 KB | Display | ![]() |
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Full document | ![]() | 489.7 KB | Display | |
Data in XML | ![]() | 57.1 KB | Display | |
Data in CIF | ![]() | 77.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2wxwC ![]() 2wxyC ![]() 2wxzC ![]() 2wy0C ![]() 2wy1C ![]() 2x0bC C: citing same article ( |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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