Entry Database : PDB / ID : 2wd1 Structure visualization Downloads & linksTitle Human c-Met Kinase in complex with azaindole inhibitor ComponentsHEPATOCYTE GROWTH FACTOR RECEPTOR C-Met Details Keywords TRANSFERASE / HUMAN KINASE / C-MET / AZAINDOLE / INHIBITOR / KINASE / NUCLEOTIDE-BINDING / ATP-BINDING / TYROSINE-PROTEIN KINASEFunction / homology Function and homology informationFunction Domain/homology Component
hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / Drug-mediated inhibition of MET activation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins / MET Receptor Activation / semaphorin receptor activity / positive regulation of endothelial cell chemotaxis ... hepatocyte growth factor receptor activity / negative regulation of guanyl-nucleotide exchange factor activity / Drug-mediated inhibition of MET activation / endothelial cell morphogenesis / MET activates STAT3 / negative regulation of hydrogen peroxide-mediated programmed cell death / MET interacts with TNS proteins / MET Receptor Activation / semaphorin receptor activity / positive regulation of endothelial cell chemotaxis / MET receptor recycling / pancreas development / MET activates PTPN11 / MET activates RAP1 and RAC1 / Sema4D mediated inhibition of cell attachment and migration / MET activates PI3K/AKT signaling / negative regulation of stress fiber assembly / negative regulation of Rho protein signal transduction / MET activates PTK2 signaling / branching morphogenesis of an epithelial tube / positive chemotaxis / negative regulation of thrombin-activated receptor signaling pathway / semaphorin-plexin signaling pathway / establishment of skin barrier / MET activates RAS signaling / phagocytosis / MECP2 regulates neuronal receptors and channels / positive regulation of microtubule polymerization / negative regulation of autophagy / basal plasma membrane / InlB-mediated entry of Listeria monocytogenes into host cell / liver development / molecular function activator activity / Negative regulation of MET activity / receptor protein-tyrosine kinase / neuron differentiation / cell surface receptor protein tyrosine kinase signaling pathway / Constitutive Signaling by Aberrant PI3K in Cancer / cell migration / PIP3 activates AKT signaling / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / protein phosphatase binding / protein tyrosine kinase activity / cell surface receptor signaling pathway / receptor complex / phosphorylation / cell surface / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular region / ATP binding / membrane / identical protein binding / plasma membrane Similarity search - Function Tyrosine-protein kinase, HGF/MSP receptor / Plexin family / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / IPT/TIG domain ... Tyrosine-protein kinase, HGF/MSP receptor / Plexin family / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / IPT/TIG domain / ig-like, plexins, transcription factors / PSI domain / domain found in Plexins, Semaphorins and Integrins / IPT domain / Immunoglobulin E-set / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / WD40/YVTN repeat-like-containing domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Porter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Le Riche, K. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. ...Porter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Le Riche, K. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. / Delgado, J. / King, L. / Foley, A. / Lecomte, F. / Reuberson, J. / Meier, C. / Batchelor, M. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2009Title : Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase.Authors: Porter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Riche, K.L. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. / Delgado, J. / King, L. / Foley, A. / ... Authors : Porter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Riche, K.L. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. / Delgado, J. / King, L. / Foley, A. / Lecomte, F. / Reuberson, J. / Meier, C. / Batchelor, M. History Deposition Mar 19, 2009 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 28, 2009 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.