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TitleDiscovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 2780-, Year 2009
Publish dateMar 19, 2009 (structure data deposition date)
AuthorsPorter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Riche, K.L. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. ...Porter, J. / Lumb, S. / Franklin, R.J. / Gascon-Simorte, J.M. / Calmiano, M. / Riche, K.L. / Lallemand, B. / Keyaerts, J. / Edwards, H. / Maloney, A. / Delgado, J. / King, L. / Foley, A. / Lecomte, F. / Reuberson, J. / Meier, C. / Batchelor, M.
External linksBioorg. Med. Chem. Lett. / PubMed:19369077
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2wd1:
Human c-Met Kinase in complex with azaindole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZZY:
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE

ChemComp-GBL:
GAMMA-BUTYROLACTONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HUMAN KINASE / C-MET / AZAINDOLE / INHIBITOR / KINASE / NUCLEOTIDE-BINDING / ATP-BINDING / TYROSINE-PROTEIN KINASE

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