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Yorodumi- PDB-2w0d: Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Cr... -
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-Basic information
Entry | Database: PDB / ID: 2w0d | ||||||
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Title | Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases. | ||||||
Components | MACROPHAGE METALLOELASTASE | ||||||
Keywords | HYDROLASE / GLYCOPROTEIN / METAL-BINDING / METALLOPROTEASE / SECRETED / HYDROXAMATE / EXTRACELLULAR MATRIX / COPD / MMP-12 / ZYMOGEN | ||||||
Function / homology | Function and homology information macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development ...macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development / response to amyloid-beta / positive regulation of interferon-alpha production / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / core promoter sequence-specific DNA binding / collagen binding / Degradation of the extracellular matrix / extracellular matrix / extracellular matrix organization / cellular response to virus / metalloendopeptidase activity / protein import into nucleus / endopeptidase activity / sequence-specific DNA binding / serine-type endopeptidase activity / calcium ion binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / proteolysis / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å | ||||||
Authors | Isaksson, J. / Nystrom, S. / Derbyshire, D.J. / Wallberg, H. / Agback, T. / Kovacs, H. / Bertini, I. / Felli, I.C. | ||||||
Citation | Journal: J.Med.Chem. / Year: 2009 Title: Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? a Case Study of Metalloproteinases. Authors: Isaksson, J. / Nystrom, S. / Derbyshire, D.J. / Wallberg, H. / Agback, T. / Kovacs, H. / Bertini, I. / Felli, I.C. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2w0d.cif.gz | 163.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2w0d.ent.gz | 127.6 KB | Display | PDB format |
PDBx/mmJSON format | 2w0d.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/w0/2w0d ftp://data.pdbj.org/pub/pdb/validation_reports/w0/2w0d | HTTPS FTP |
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-Related structure data
Related structure data | |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Noncrystallographic symmetry (NCS) | NCS domain:
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