登録情報 | データベース: PDB / ID: 2uv2 |
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タイトル | Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile |
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要素 | STE20-LIKE SERINE-THREONINE KINASE |
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キーワード | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / PHOSPHORYLATION / MUSCLE DEVELOPMENT / KINASE / APOPTOSIS / GERMINAL CENTRE KINASE / SERINE- THREONINE KINASE 2 / NUCLEOTIDE-BINDING / SERINE-THREONINE-PROTEIN KINASE |
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機能・相同性 | 機能・相同性情報
regulation of focal adhesion assembly / RHOB GTPase cycle / RHOC GTPase cycle / cell leading edge / RHOA GTPase cycle / cytoplasmic microtubule organization / regulation of cell migration / regulation of apoptotic process / protein autophosphorylation / non-specific serine/threonine protein kinase ...regulation of focal adhesion assembly / RHOB GTPase cycle / RHOC GTPase cycle / cell leading edge / RHOA GTPase cycle / cytoplasmic microtubule organization / regulation of cell migration / regulation of apoptotic process / protein autophosphorylation / non-specific serine/threonine protein kinase / cadherin binding / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / perinuclear region of cytoplasm / protein homodimerization activity / extracellular exosome / ATP binding / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 Polo kinase kinase / Polo kinase kinase / UVR domain / UVR domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ...Polo kinase kinase / Polo kinase kinase / UVR domain / UVR domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-GVD / THIOCYANATE ION / STE20-like serine/threonine-protein kinase類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Pike, A.C.W. / Rellos, P. / Fedorov, O. / Keates, T. / Salah, E. / Savitsky, P. / Papagrigoriou, E. / Bunkoczi, G. / Debreczeni, J.E. / von Delft, F. ...Pike, A.C.W. / Rellos, P. / Fedorov, O. / Keates, T. / Salah, E. / Savitsky, P. / Papagrigoriou, E. / Bunkoczi, G. / Debreczeni, J.E. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Weigelt, J. / Sundstrom, M. / Knapp, S. |
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引用 | ジャーナル: Embo J. / 年: 2008 タイトル: Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. 著者: Pike, A.C.W. / Rellos, P. / Niesen, F.H. / Turnbull, A. / Oliver, A.W. / Parker, S.A. / Turk, B.E. / Pearl, L.H. / Knapp, S. |
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履歴 | 登録 | 2007年3月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
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置き換え | 2007年3月20日 | ID: 2JA0 |
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改定 1.0 | 2007年3月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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改定 1.3 | 2023年12月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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