3.0 Angstrom Crystal Structure of 3-dehydroquinate Synthase (AroB) from Francisella tularensis in Complex with NAD.
Components
3-dehydroquinate synthase
Keywords
LYASE / 3-dehydroquinate synthase / NAD / Shikimate Pathway / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID
Function / homology
Function and homology information
3-dehydroquinate synthase / 3-dehydroquinate synthase activity / chorismate biosynthetic process / aromatic amino acid family biosynthetic process / amino acid biosynthetic process / nucleotide binding / metal ion binding / cytoplasm Similarity search - Function
Resolution: 3→29.83 Å / Cor.coef. Fo:Fc: 0.966 / Cor.coef. Fo:Fc free: 0.952 / SU B: 16.475 / SU ML: 0.149 / Cross valid method: THROUGHOUT / ESU R: 0.331 / ESU R Free: 0.238 / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.19223
968
5.2 %
RANDOM
Rwork
0.15743
-
-
-
obs
0.15911
17684
99.71 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å