登録情報 データベース : PDB / ID : 2rh1 構造の表示 ダウンロードとリンクタイトル High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. 要素beta-2-adrenergic receptor/T4-lysozyme chimera 詳細 キーワード MEMBRANE PROTEIN / HYDROLASE / GPCR / 7TM / adrenergic / fusion / lipidic cubic phase / lipidic / mesophase / cholesterol / membrane protein / MEMBRANE PROTEIN - HYDROLASE COMPLEX / Structural Genomics / PSI-2 / Protein Structure Initiative / Accelerated Technologies Center for Gene to 3D Structure / ATCG3D / GPCR Network機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
: / beta2-adrenergic receptor activity / positive regulation of mini excitatory postsynaptic potential / positive regulation of cAMP-dependent protein kinase activity / norepinephrine binding / Adrenoceptors / heat generation / positive regulation of autophagosome maturation / positive regulation of AMPA receptor activity / norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure ... : / beta2-adrenergic receptor activity / positive regulation of mini excitatory postsynaptic potential / positive regulation of cAMP-dependent protein kinase activity / norepinephrine binding / Adrenoceptors / heat generation / positive regulation of autophagosome maturation / positive regulation of AMPA receptor activity / norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure / activation of transmembrane receptor protein tyrosine kinase activity / negative regulation of smooth muscle contraction / positive regulation of lipophagy / response to psychosocial stress / negative regulation of multicellular organism growth / adrenergic receptor signaling pathway / endosome to lysosome transport / diet induced thermogenesis / neuronal dense core vesicle / positive regulation of protein kinase A signaling / adenylate cyclase binding / smooth muscle contraction / potassium channel regulator activity / positive regulation of bone mineralization / brown fat cell differentiation / adenylate cyclase-activating adrenergic receptor signaling pathway / regulation of sodium ion transport / viral release from host cell by cytolysis / bone resorption / activation of adenylate cyclase activity / response to cold / peptidoglycan catabolic process / receptor-mediated endocytosis / clathrin-coated endocytic vesicle membrane / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / positive regulation of protein serine/threonine kinase activity / cellular response to amyloid-beta / cell wall macromolecule catabolic process / Cargo recognition for clathrin-mediated endocytosis / lysozyme / Clathrin-mediated endocytosis / lysozyme activity / positive regulation of cold-induced thermogenesis / amyloid-beta binding / G alpha (s) signalling events / host cell cytoplasm / transcription by RNA polymerase II / positive regulation of MAPK cascade / cell surface receptor signaling pathway / lysosome / early endosome / receptor complex / endosome membrane / Ub-specific processing proteases / endosome / defense response to bacterium / apical plasma membrane / protein-containing complex binding / Golgi apparatus / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / identical protein binding / membrane / nucleus / plasma membrane 類似検索 - 分子機能 Beta 2 adrenoceptor / Adrenoceptor family / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme ... Beta 2 adrenoceptor / Adrenoceptor family / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / Lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 alpha-maltose / ACETAMIDE / 1,4-BUTANEDIOL / Chem-CAU / CHOLESTEROL / PALMITIC ACID / Endolysin / Beta-2 adrenergic receptor 類似検索 - 構成要素生物種 Homo sapiens (ヒト) Enterobacteria phage T4 (ファージ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.4 Å 詳細データ登録者 Cherezov, V. / Rosenbaum, D.M. / Hanson, M.A. / Rasmussen, S.G.F. / Thian, F.S. / Kobilka, T.S. / Choi, H.J. / Kuhn, P. / Weis, W.I. / Kobilka, B.K. ...Cherezov, V. / Rosenbaum, D.M. / Hanson, M.A. / Rasmussen, S.G.F. / Thian, F.S. / Kobilka, T.S. / Choi, H.J. / Kuhn, P. / Weis, W.I. / Kobilka, B.K. / Stevens, R.C. / Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) / GPCR Network (GPCR) 引用ジャーナル : Science / 年 : 2007タイトル : High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
著者 :
Cherezov, V. / Rosenbaum, D.M. / Hanson, M.A. / Rasmussen, S.G. / Thian, F.S. / Kobilka, T.S. / Choi, H.J. / Kuhn, P. / Weis, W.I. / Kobilka, B.K. / Stevens, R.C. 残り1件を表示 表示を減らす#1: ジャーナル : To be Published タイトル : GPCR Engineering Yields High-Resolution Structural Insights into beta2 Adrenergic Receptor Function.
著者 :
Rosenbaum, D.M. / Cherezov, V. / Hanson, M.A. / Rasmussen, S.G.F. / Thian, F.S. / Kobilka, T.S. / Choi, H.J. / Yao, X.J. / Weis, W.I. / Stevens, R.C. / Kobilka, B.K. 履歴 登録 2007年10月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年10月30日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 1.2 2012年8月8日 Group : Other改定 1.3 2017年8月2日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 1.4 2017年10月11日 Group : Data collection / カテゴリ : reflns_shell / Item : _reflns_shell.percent_possible_all改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / database_PDB_caveat / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / pdbx_validate_chiral / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type / _pdbx_validate_chiral.auth_asym_id / _pdbx_validate_chiral.auth_atom_id / _pdbx_validate_chiral.auth_comp_id / _pdbx_validate_chiral.auth_seq_id / _struct_ref_seq_dif.details 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2021年10月20日 Group : Database references / Structure summary / カテゴリ : chem_comp / database_2 / struct_ref_seq_difItem : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details 改定 2.2 2023年8月30日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
すべて表示 表示を減らす Remark 600 HETEROGEN THE PALMITIC ACID (PLM) AND ACETAMIDE (ACM) GROUPS ARE COVALENTLY LINKED TO THEIR ... HETEROGEN THE PALMITIC ACID (PLM) AND ACETAMIDE (ACM) GROUPS ARE COVALENTLY LINKED TO THEIR RESPECTIVE CYSTEINE RESIDUES. Remark 999 SEQUENCE THE STRUCTURE IS AN INTERNAL FUSION PROTEIN WITH LYSOZYME. AN OFFSET 1000 HAS BEEN ADDED ... SEQUENCE THE STRUCTURE IS AN INTERNAL FUSION PROTEIN WITH LYSOZYME. AN OFFSET 1000 HAS BEEN ADDED TO ORIGINAL SEQUENCE DATABASE RESIDUE NUMBERS (2-161) OF THE LYSOZYME PART IN COORDINATES TO DISTINGUISH THE LYSOZYME PART IN THE CHAIN. THEREFORE THE RESIDUES OF LYSOZYME PART HAVE NUMBERS A1002-A1161.