登録情報 | データベース: PDB / ID: 2r4h |
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タイトル | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase |
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要素 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 |
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キーワード | TRANSFERASE / PDZ / MEMBRANE ASSOCIATED GUANYLATE KINASE / Structural Genomics / Structural Genomics Consortium / SGC / ATP-binding / Cell junction / Nucleotide-binding / Phosphorylation / Tight junction |
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機能・相同性 | 機能・相同性情報
positive regulation of cell-cell adhesion / endothelial cell morphogenesis / alpha-actinin binding / bicellular tight junction / cell periphery / cell projection / adherens junction / cell junction / cell-cell junction / protein-containing complex assembly ...positive regulation of cell-cell adhesion / endothelial cell morphogenesis / alpha-actinin binding / bicellular tight junction / cell periphery / cell projection / adherens junction / cell junction / cell-cell junction / protein-containing complex assembly / cell surface receptor signaling pathway / cell adhesion / nucleolus / signal transduction / nucleoplasm / ATP binding / plasma membrane / cytoplasm類似検索 - 分子機能 Unstructured region on MAGI / Unstructured region on MAGI / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / WW domain ...Unstructured region on MAGI / Unstructured region on MAGI / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / WW domain / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 HISTIDINE / Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.05 Å |
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データ登録者 | Ugochukwu, E. / Pilka, E.S. / Hozjan, V. / Kavanagh, K.L. / Cooper, C. / Pike, A.C.W. / Elkins, J.M. / Doyle, D.A. / von Delft, F. / Sundstrom, M. ...Ugochukwu, E. / Pilka, E.S. / Hozjan, V. / Kavanagh, K.L. / Cooper, C. / Pike, A.C.W. / Elkins, J.M. / Doyle, D.A. / von Delft, F. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Oppermann, U. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: To be Published タイトル: Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase. 著者: Ugochukwu, E. / Pilka, E.S. / Hozjan, V. / Kavanagh, K.L. / Cooper, C. / Pike, A.C.W. / Elkins, J.M. / Doyle, D.A. / von Delft, F. / Sundstrom, M. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A.M. / Oppermann, U. |
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履歴 | 登録 | 2007年8月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年10月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2023年8月30日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id |
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