Entry Database : PDB / ID : 2n12 Structure visualization Downloads & linksTitle Solution structure of human Myosin VI isoform3 (1050-1131) ComponentsUnconventional myosin-VI Details Keywords MOTOR PROTEIN / PROTEIN TRANSPORTFunction / homology Function and homology informationFunction Domain/homology Component
regulation of secretion / minus-end directed microfilament motor activity / unconventional myosin complex / actin filament-based movement / inner ear auditory receptor cell differentiation / clathrin-coated vesicle membrane / Gap junction degradation / vesicle transport along actin filament / Trafficking of AMPA receptors / RHOBTB1 GTPase cycle ... regulation of secretion / minus-end directed microfilament motor activity / unconventional myosin complex / actin filament-based movement / inner ear auditory receptor cell differentiation / clathrin-coated vesicle membrane / Gap junction degradation / vesicle transport along actin filament / Trafficking of AMPA receptors / RHOBTB1 GTPase cycle / inner ear morphogenesis / microfilament motor activity / cytoskeletal motor activity / filamentous actin / microvillus / RHOU GTPase cycle / DNA damage response, signal transduction by p53 class mediator / endocytic vesicle / autophagosome / RHOBTB2 GTPase cycle / clathrin-coated pit / ruffle / filopodium / actin filament / actin filament organization / sensory perception of sound / intracellular protein transport / protein localization / ADP binding / ruffle membrane / endocytosis / actin filament binding / actin cytoskeleton / apical part of cell / actin binding / cell cortex / cytoplasmic vesicle / nuclear membrane / calmodulin binding / endosome / response to xenobiotic stimulus / lysosomal membrane / perinuclear region of cytoplasm / Golgi apparatus / extracellular exosome / nucleoplasm / ATP binding / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function : / Myosin VI, lever arm / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head, motor domain / Myosin head (motor domain) ... : / Myosin VI, lever arm / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / Kinesin motor domain superfamily / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / simulated annealing DetailsModel details lowest energy, model1 Authors He, F. / Walters, K. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) CA136472 United States National Institutes of Health/National Cancer Institute (NIH/NCI) 1ZIABC011627 United States
CitationJournal : Nat.Struct.Mol.Biol. / Year : 2016Title : Diverse functions of myosin VI elucidated by an isoform-specific alpha-helix domain.Authors : Wollscheid, H.P. / Biancospino, M. / He, F. / Magistrati, E. / Molteni, E. / Lupia, M. / Soffientini, P. / Rottner, K. / Cavallaro, U. / Pozzoli, U. / Mapelli, M. / Walters, K.J. / Polo, S. History Deposition Mar 20, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 2, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Mar 30, 2016 Group : Database referencesRevision 1.2 Apr 27, 2016 Group : Database referencesRevision 1.3 Oct 13, 2021 Group : Data collection / Database referencesCategory : database_2 / pdbx_nmr_software / pdbx_nmr_spectrometerItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model Revision 2.0 Nov 3, 2021 Group : Advisory / Atomic model ... Advisory / Atomic model / Author supporting evidence / Data collection / Database references / Derived calculations / Experimental preparation / Other / Refinement description / Source and taxonomy / Structure summary Category : atom_site / entity_src_gen ... atom_site / entity_src_gen / pdbx_audit_support / pdbx_contact_author / pdbx_database_related / pdbx_database_status / pdbx_nmr_ensemble / pdbx_nmr_exptl / pdbx_nmr_exptl_sample / pdbx_nmr_exptl_sample_conditions / pdbx_nmr_refine / pdbx_nmr_sample_details / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_validate_close_contact / pdbx_validate_torsion / struct / struct_conf Item : _atom_site.Cartn_x / _atom_site.Cartn_y ... _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _entity_src_gen.gene_src_common_name / _entity_src_gen.pdbx_beg_seq_num / _entity_src_gen.pdbx_end_seq_num / _entity_src_gen.pdbx_seq_type / _pdbx_contact_author.id / _pdbx_contact_author.identifier_ORCID / _pdbx_contact_author.name_salutation / _pdbx_database_status.SG_entry / _pdbx_database_status.deposit_site / _pdbx_nmr_ensemble.conformer_selection_criteria / _pdbx_nmr_ensemble.conformers_calculated_total_number / _pdbx_nmr_exptl.sample_state / _pdbx_nmr_exptl.spectrometer_id / _pdbx_nmr_exptl_sample.component / _pdbx_nmr_exptl_sample_conditions.ionic_strength_units / _pdbx_nmr_exptl_sample_conditions.label / _pdbx_nmr_exptl_sample_conditions.pH_units / _pdbx_nmr_refine.software_ordinal / _pdbx_nmr_sample_details.contents / _pdbx_nmr_sample_details.label / _pdbx_nmr_sample_details.type / _pdbx_nmr_software.classification / _pdbx_nmr_spectrometer.type / _struct.pdbx_CASP_flag / _struct_conf.end_auth_comp_id / _struct_conf.end_auth_seq_id / _struct_conf.end_label_comp_id / _struct_conf.end_label_seq_id / _struct_conf.pdbx_PDB_helix_id / _struct_conf.pdbx_PDB_helix_length Description : Atoms with unrealistic or zero occupancies / Provider : author / Type : Coordinate replacementRevision 2.1 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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