登録情報 データベース : PDB / ID : 2lb2 構造の表示 ダウンロードとリンクタイトル Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3 要素E3 ubiquitin-protein ligase NEDD4-like Mothers against decapentaplegic homolog 3 詳細キーワード SIGNALING PROTEIN/TRANSCRIPTION / Nedd4L / SMAD / CDK / signal transduction / SIGNALING PROTEIN-TRANSCRIPTION complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
nuclear mineralocorticoid receptor binding / negative regulation of lung blood pressure / regulation of miRNA transcription / positive regulation of transforming growth factor beta3 production / transdifferentiation / sterol response element binding / paraxial mesoderm morphogenesis / positive regulation of caveolin-mediated endocytosis / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer ... nuclear mineralocorticoid receptor binding / negative regulation of lung blood pressure / regulation of miRNA transcription / positive regulation of transforming growth factor beta3 production / transdifferentiation / sterol response element binding / paraxial mesoderm morphogenesis / positive regulation of caveolin-mediated endocytosis / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / RING-type E3 ubiquitin transferase (cysteine targeting) / negative regulation of sodium ion transmembrane transport / nodal signaling pathway / regulation of striated muscle tissue development / SMAD protein complex / immune system development / negative regulation of potassium ion transmembrane transporter activity / co-SMAD binding / heteromeric SMAD protein complex / regulation of transforming growth factor beta2 production / regulation of potassium ion transmembrane transporter activity / negative regulation of potassium ion transmembrane transport / RUNX3 regulates BCL2L11 (BIM) transcription / DEAD/H-box RNA helicase binding / bHLH transcription factor binding / pericardium development / regulation of sodium ion transmembrane transport / FOXO-mediated transcription of cell cycle genes / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / negative regulation of sodium ion transmembrane transporter activity / positive regulation of chondrocyte differentiation / negative regulation of osteoblast proliferation / negative regulation of protein localization to cell surface / regulation of membrane repolarization / regulation of transforming growth factor beta receptor signaling pathway / embryonic foregut morphogenesis / negative regulation of wound healing / positive regulation of extracellular matrix assembly / lens fiber cell differentiation / regulation of membrane depolarization / primary miRNA processing / transforming growth factor beta receptor binding / Germ layer formation at gastrulation / nuclear glucocorticoid receptor binding / endoderm development / positive regulation of dendrite extension / Formation of definitive endoderm / embryonic pattern specification / signal transduction involved in regulation of gene expression / activin receptor signaling pathway / SMAD protein signal transduction / Signaling by Activin / ventricular cardiac muscle cell action potential / Formation of axial mesoderm / potassium channel inhibitor activity / HECT-type E3 ubiquitin transferase / cell-cell junction organization / regulation of epithelial cell proliferation / Signaling by NODAL / embryonic cranial skeleton morphogenesis / I-SMAD binding / sodium channel inhibitor activity / Interleukin-37 signaling / response to angiotensin / regulation of monoatomic ion transmembrane transport / positive regulation of positive chemotaxis / osteoblast development / NOTCH4 Intracellular Domain Regulates Transcription / negative regulation of cardiac muscle hypertrophy in response to stress / RUNX3 regulates CDKN1A transcription / nuclear inner membrane / ureteric bud development / DNA-binding transcription repressor activity / adrenal gland development / regulation of dendrite morphogenesis / negative regulation of fat cell differentiation / negative regulation of cytosolic calcium ion concentration / heart looping / TGF-beta receptor signaling activates SMADs / protein monoubiquitination / positive regulation of focal adhesion assembly / R-SMAD binding / thyroid gland development / mesoderm formation / developmental growth / regulation of immune response / potassium channel regulator activity / sodium channel regulator activity / phosphatase binding / negative regulation of osteoblast differentiation / anatomical structure morphogenesis / cis-regulatory region sequence-specific DNA binding / protein K48-linked ubiquitination / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / positive regulation of bone mineralization / somitogenesis / positive regulation of epithelial to mesenchymal transition / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / extrinsic apoptotic signaling pathway 類似検索 - 分子機能 MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain ... MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / E3 ubiquitin-protein ligase, SMURF1 type / SMAD-like domain superfamily / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / C2 domain / Protein kinase C conserved region 2 (CalB) / SMAD/FHA domain superfamily / WW domain / WW/rsp5/WWP domain signature. / C2 domain / C2 domain profile. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / C2 domain superfamily 類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 3 / E3 ubiquitin-protein ligase NEDD4-like 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細Model details lowest energy, model 1 データ登録者 Macias, M.J. / Aragon, E. / Goerner, N. / Zaromytidou, A. / Xi, Q. / Escobedo, A. / Massague, J. 引用ジャーナル : Genes Dev. / 年 : 2011タイトル : A Smad action turnover switch operated by WW domain readers of a phosphoserine code.著者 : Aragon, E. / Goerner, N. / Zaromytidou, A.I. / Xi, Q. / Escobedo, A. / Massague, J. / Macias, M.J. 履歴 登録 2011年3月22日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2011年7月6日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance
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