Entry Database : PDB / ID : 2j7i Structure visualization Downloads & linksTitle ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETERODIMER ComponentsCD2-ASSOCIATED PROTEIN T-CELL SURFACE ANTIGEN CD2 DetailsKeywords PROTEIN BINDING / COILED COIL / POLYMORPHISM / GLYCOPROTEIN / CELL ADHESION / EGFR DOWNREGULATION / IMMUNOGLOBULIN DOMAIN / TRANSMEMBRANE / PHOSPHORYLATION / ADAPTOR PROTEIN / CMS / CD2AD / MEMBRANE / SH3 DOMAIN / SH3-BINDING / SH3 DOMAIN RECOGNITIONFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of myeloid dendritic cell activation / membrane raft polarization / response to glial cell derived neurotrophic factor / negative regulation of small GTPase mediated signal transduction / transforming growth factor beta1 production / localization of cell / Rab protein signal transduction / negative regulation of transforming growth factor beta1 production / slit diaphragm / response to transforming growth factor beta ... positive regulation of myeloid dendritic cell activation / membrane raft polarization / response to glial cell derived neurotrophic factor / negative regulation of small GTPase mediated signal transduction / transforming growth factor beta1 production / localization of cell / Rab protein signal transduction / negative regulation of transforming growth factor beta1 production / slit diaphragm / response to transforming growth factor beta / podocyte differentiation / immunological synapse formation / endothelium development / nerve growth factor signaling pathway / cell-cell adhesion mediated by cadherin / collateral sprouting / protein heterooligomerization / renal albumin absorption / substrate-dependent cell migration, cell extension / membrane organization / phosphatidylinositol 3-kinase regulatory subunit binding / natural killer cell mediated cytotoxicity / natural killer cell activation / cell-cell junction organization / filopodium assembly / podosome / Nephrin family interactions / heterotypic cell-cell adhesion / regulation of T cell differentiation / clathrin binding / maintenance of blood-brain barrier / nuclear envelope lumen / cell leading edge / glucose import / filamentous actin / neurotrophin TRK receptor signaling pathway / centriolar satellite / protein secretion / lymph node development / adipose tissue development / stress-activated MAPK cascade / ruffle / T cell activation / ERK1 and ERK2 cascade / actin filament polymerization / phosphatidylinositol 3-kinase/protein kinase B signal transduction / trans-Golgi network membrane / liver development / positive regulation of interleukin-8 production / positive regulation of protein secretion / Cell surface interactions at the vascular wall / regulation of actin cytoskeleton organization / actin filament organization / synapse organization / protein catabolic process / response to virus / regulation of synaptic plasticity / response to insulin / neuromuscular junction / lipid metabolic process / structural constituent of cytoskeleton / cytoplasmic side of plasma membrane / receptor tyrosine kinase binding / fibrillar center / cell-cell adhesion / response to wounding / SH3 domain binding / positive regulation of protein localization to nucleus / : / male gonad development / positive regulation of tumor necrosis factor production / positive regulation of type II interferon production / cell-cell junction / actin filament binding / cell migration / actin cytoskeleton / late endosome / signaling receptor activity / T cell receptor signaling pathway / growth cone / protein-containing complex assembly / vesicle / response to oxidative stress / negative regulation of neuron apoptotic process / cell population proliferation / cell surface receptor signaling pathway / cadherin binding / inflammatory response / cell cycle / cell division / external side of plasma membrane / axon / signaling receptor binding / apoptotic process / dendrite / Golgi apparatus / cell surface / signal transduction / protein-containing complex / extracellular exosome Similarity search - Function T-cell surface antigen CD2 / CD2-associated protein, first SH3 domain / CD2-associated protein, second SH3 domain / CD2-associated protein, third SH3 domain / Immunoglobulin C2-set / Immunoglobulin C2-set domain / Variant SH3 domain / SH3 Domains / SH3 domain / Immunoglobulin V-set domain ... T-cell surface antigen CD2 / CD2-associated protein, first SH3 domain / CD2-associated protein, second SH3 domain / CD2-associated protein, third SH3 domain / Immunoglobulin C2-set / Immunoglobulin C2-set domain / Variant SH3 domain / SH3 Domains / SH3 domain / Immunoglobulin V-set domain / SH3 type barrels. / Immunoglobulin V-set domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.9 Å DetailsAuthors Moncalian, G. / Cardenes, N. / Deribe, Y.L. / Spinola-Amilibia, M. / Dikic, I. / Bravo, J. CitationJournal : J.Biol.Chem. / Year : 2006Title : Atypical Polyproline Recognition by the Cms N-Terminal Src Homology 3 Domain.Authors : Moncalian, G. / Cardenes, N. / Deribe, Y.L. / Spinola-Amilibia, M. / Dikic, I. / Bravo, J. History Deposition Oct 9, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 6, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jul 5, 2017 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.typeRevision 1.4 May 1, 2024 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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