Entry | Database: PDB / ID: 2cia |
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Title | human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec |
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Components | - CYTOPLASMIC PROTEIN NCK2
- TRANSLOCATED INTIMIN RECEPTOR
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Keywords | SH2-DOMAIN / SH3 DOMAIN / PHOSPHORYLATION / BINDING SPECIFICITY |
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Function / homology | Function and homology information
Regulation of cortical dendrite branching / negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation / : / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / immunological synapse formation / dendritic spine development / cytoskeletal anchor activity / signal complex assembly / Activation of RAC1 ...Regulation of cortical dendrite branching / negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation / : / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / immunological synapse formation / dendritic spine development / cytoskeletal anchor activity / signal complex assembly / Activation of RAC1 / vesicle membrane / Nephrin family interactions / Ephrin signaling / lamellipodium assembly / RHOV GTPase cycle / positive regulation of actin filament polymerization / negative regulation of PERK-mediated unfolded protein response / RHOU GTPase cycle / ephrin receptor signaling pathway / signaling adaptor activity / positive regulation of T cell proliferation / T cell activation / phosphotyrosine residue binding / Downstream signal transduction / actin filament organization / epidermal growth factor receptor signaling pathway / receptor tyrosine kinase binding / VEGFA-VEGFR2 Pathway / signaling receptor complex adaptor activity / cell migration / scaffold protein binding / postsynaptic density / negative regulation of cell population proliferation / protein-containing complex binding / host cell plasma membrane / negative regulation of transcription by RNA polymerase II / signal transduction / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / extracellular region / membrane / cytosol / cytoplasmSimilarity search - Function Translocated intimin receptor, central domain / Translocated intimin receptor, N-terminal / Translocated intimin receptor / Translocated intimin receptor, C-terminal / Translocated intimin receptor, central domain superfamily / Translocated intimin receptor (Tir) intimin-binding domain / Translocated intimin receptor (Tir) C-terminus / Translocated intimin receptor (Tir) N-terminus / Nck2, SH3 domain 1 / Nck2, SH3 domain 2 ...Translocated intimin receptor, central domain / Translocated intimin receptor, N-terminal / Translocated intimin receptor / Translocated intimin receptor, C-terminal / Translocated intimin receptor, central domain superfamily / Translocated intimin receptor (Tir) intimin-binding domain / Translocated intimin receptor (Tir) C-terminus / Translocated intimin receptor (Tir) N-terminus / Nck2, SH3 domain 1 / Nck2, SH3 domain 2 / Nck2, SH3 domain 3 / Nck2, SH2 domain / Cytoplasmic protein NCK / : / Variant SH3 domain / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology ISOPROPYL ALCOHOL / Translocated intimin receptor Tir / Cytoplasmic protein NCK2 / Translocated intimin receptor TirSimilarity search - Component |
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Biological species | HOMO SAPIENS (human)
![](img/tx_bacteria.gif) ESCHERICHIA COLI (E. coli) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.45 Å |
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Authors | Frese, S. / Schubert, W.-D. / Findeis, A.C. / Marquardt, T. / Roske, Y.S. / Stradal, T.E.B. / Heinz, D.W. |
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Citation | Journal: J.Biol.Chem. / Year: 2006 Title: The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. Authors: Frese, S. / Schubert, W.-D. / Findeis, A.C. / Marquardt, T. / Roske, Y.S. / Stradal, T.E.B. / Heinz, D.W. |
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History | Deposition | Mar 17, 2006 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Apr 24, 2006 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | May 29, 2019 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Experimental preparation / Other Category: exptl_crystal_grow / pdbx_database_proc ...exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol / struct_conn Item: _exptl_crystal_grow.method / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag |
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Revision 1.3 | May 1, 2024 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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Remark 650 | HELIX DETERMINATION METHOD: AUTHOR PROVIDED. |
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Remark 700 | SHEET DETERMINATION METHOD: AUTHOR PROVIDED. |
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