登録情報 データベース : PDB / ID : 2ak5 構造の表示 ダウンロードとリンクタイトル beta PIX-SH3 complexed with a Cbl-b peptide 要素8-residue peptide from a signal transduction protein CBL-B Rho guanine nucleotide exchange factor 7 詳細キーワード ENDOCYTOSIS/EXOCYTOSIS / adaptor proteins / Cin85 / PIX/COOL / Cbl / protein-protein interaction / endocytosis / ENDOCYTOSIS-EXOCYTOSIS COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
presynaptic actin cytoskeleton organization / negative regulation of microtubule nucleation / Ephrin signaling / NRAGE signals death through JNK / EGFR downregulation / RHOU GTPase cycle / RHOV GTPase cycle / G alpha (12/13) signalling events / RHOQ GTPase cycle / RAC1 GTPase cycle ... presynaptic actin cytoskeleton organization / negative regulation of microtubule nucleation / Ephrin signaling / NRAGE signals death through JNK / EGFR downregulation / RHOU GTPase cycle / RHOV GTPase cycle / G alpha (12/13) signalling events / RHOQ GTPase cycle / RAC1 GTPase cycle / RHOA GTPase cycle / regulation of platelet-derived growth factor receptor-alpha signaling pathway / storage vacuole / T cell anergy / astrocyte cell migration / positive regulation of T cell anergy / positive regulation of growth hormone secretion / postsynaptic actin cytoskeleton organization / CD4-positive, alpha-beta T cell proliferation / negative regulation of CD4-positive, alpha-beta T cell proliferation / gamma-tubulin binding / lamellipodium assembly / negative regulation of T cell receptor signaling pathway / small GTPase-mediated signal transduction / NLS-bearing protein import into nucleus / mitotic spindle pole / Golgi organization / Rho protein signal transduction / hematopoietic progenitor cell differentiation / GABA-ergic synapse / ruffle / phosphotyrosine residue binding / guanyl-nucleotide exchange factor activity / positive regulation of protein ubiquitination / RING-type E3 ubiquitin transferase / protein catabolic process / receptor tyrosine kinase binding / SH3 domain binding / positive regulation of protein catabolic process / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / lamellipodium / T cell receptor signaling pathway / cell cortex / growth cone / postsynapse / intracellular signal transduction / protein ubiquitination / neuron projection / immune response / positive regulation of apoptotic process / membrane raft / focal adhesion / centrosome / neuronal cell body / calcium ion binding / protein kinase binding / signal transduction / protein-containing complex / zinc ion binding / nucleoplasm / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Rho guanine nucleotide exchange factor 6/7, coiled-coil domain / betaPIX coiled coil / Rho guanine nucleotide exchange factor 7, SH3 domain / RhoGEF 6/7, PH domain / Unstructured region two on RhoGEF 6 and 7 / E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain ... Rho guanine nucleotide exchange factor 6/7, coiled-coil domain / betaPIX coiled coil / Rho guanine nucleotide exchange factor 7, SH3 domain / RhoGEF 6/7, PH domain / Unstructured region two on RhoGEF 6 and 7 / E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl / CBL proto-oncogene N-terminal domain 1 / CBL proto-oncogene N-terminus, EF hand-like domain / CBL proto-oncogene N-terminus, SH2-like domain / Cbl-type phosphotyrosine-binding (Cbl-PTB) domain profile. / Adaptor protein Cbl, N-terminal domain superfamily / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Variant SH3 domain / Ubiquitin associated domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / SH3 Domains / PH domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Zinc finger RING-type profile. / Zinc finger, RING-type / Src homology 3 domains / SH3 type barrels. / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain pair / PH-like domain superfamily / Zinc finger, RING/FYVE/PHD-type / Roll / Mainly Beta 類似検索 - ドメイン・相同性 Rho guanine nucleotide exchange factor 7 / E3 ubiquitin-protein ligase CBL-B 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.85 Å 詳細データ登録者 Jozic, D. / Cardenes, N. / Deribe, Y.L. / Moncalian, G. / Hoeller, D. / Groemping, Y. / Dikic, I. / Rittinger, K. / Bravo, J. 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2005タイトル : Cbl promotes clustering of endocytic adaptor proteins.著者 : Jozic, D. / Cardenes, N. / Deribe, Y.L. / Moncalian, G. / Hoeller, D. / Groemping, Y. / Dikic, I. / Rittinger, K. / Bravo, J. 履歴 登録 2005年8月3日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2005年10月11日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 2.0 2023年8月23日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Refinement description カテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _atom_site.occupancy / _database_2.pdbx_DOI ... _atom_site.occupancy / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
すべて表示 表示を減らす