- PDB-4rly: Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with... -
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Basic information
Entry
Database: PDB / ID: 4rly
Title
Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain
Components
Nav1.2 - AnkB chimera
Keywords
STRUCTURAL PROTEIN / ANK Repeat / Protein-protein interaction
Function / homology
Function and homology information
protein localization to T-tubule / atrial cardiac muscle cell to AV node cell communication / SA node cell to atrial cardiac muscle cell communication / regulation of calcium ion transmembrane transporter activity / positive regulation of calcium ion transmembrane transporter activity / protein localization to M-band / positive regulation of potassium ion transmembrane transporter activity / T-tubule organization / SA node cell action potential / membrane depolarization during SA node cell action potential ...protein localization to T-tubule / atrial cardiac muscle cell to AV node cell communication / SA node cell to atrial cardiac muscle cell communication / regulation of calcium ion transmembrane transporter activity / positive regulation of calcium ion transmembrane transporter activity / protein localization to M-band / positive regulation of potassium ion transmembrane transporter activity / T-tubule organization / SA node cell action potential / membrane depolarization during SA node cell action potential / protein localization to organelle / paranodal junction assembly / regulation of SA node cell action potential / regulation of atrial cardiac muscle cell action potential / phosphorylation-dependent protein binding / positive regulation of cation channel activity / atrial cardiac muscle cell action potential / protein localization to endoplasmic reticulum / sarcoplasmic reticulum calcium ion transport / intrinsic apoptotic signaling pathway in response to osmotic stress / nerve development / paranode region of axon / cytoskeletal anchor activity / atrial septum development / positive regulation of potassium ion transport / dentate gyrus development / node of Ranvier / costamere / ventricular cardiac muscle cell action potential / regulation of release of sequestered calcium ion into cytosol / response to methylmercury / positive regulation of calcium ion transport / cardiac muscle cell action potential involved in contraction / regulation of ventricular cardiac muscle cell membrane repolarization / voltage-gated sodium channel complex / M band / regulation of cardiac muscle contraction by calcium ion signaling / regulation of cardiac muscle cell contraction / protein localization to cell surface / Interaction between L1 and Ankyrins / A band / voltage-gated sodium channel activity / spectrin binding / sodium ion transport / Phase 0 - rapid depolarisation / regulation of heart rate by cardiac conduction / regulation of calcium ion transport / intercalated disc / neuronal action potential / regulation of cardiac muscle contraction / sodium ion transmembrane transport / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / COPI-mediated anterograde transport / T-tubule / myelination / regulation of heart rate / protein localization to plasma membrane / determination of adult lifespan / regulation of protein stability / recycling endosome / structural constituent of cytoskeleton / sarcolemma / memory / Sensory perception of sweet, bitter, and umami (glutamate) taste / Z disc / intracellular calcium ion homeostasis / endocytosis / protein localization / protein transport / ATPase binding / cellular response to hypoxia / nervous system development / presynaptic membrane / protein-macromolecule adaptor activity / basolateral plasma membrane / postsynaptic membrane / neuron apoptotic process / transmembrane transporter binding / calmodulin binding / early endosome / lysosome / cytoskeleton / protein stabilization / neuron projection / apical plasma membrane / axon / glutamatergic synapse / positive regulation of gene expression / protein kinase binding / enzyme binding / mitochondrion / membrane / plasma membrane / cytosol Similarity search - Function
: / Ankyrin, UPA domain / UPA domain / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain / ZU5 domain profile. / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate ...: / Ankyrin, UPA domain / UPA domain / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain / ZU5 domain profile. / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Death domain profile. / Voltage-gated cation channel calcium and sodium / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Ankyrin repeat-containing domain / Ankyrin repeats (many copies) / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif, EF-hand binding site / IQ motif profile. / Voltage-dependent channel domain superfamily / Death-like domain superfamily / Ankyrin repeat / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ion transport domain / Ion transport protein / Alpha Horseshoe / Mainly Alpha Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 74 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 3.98 Å3/Da / Density % sol: 69.12 %
Crystal grow
Temperature: 289 K / Method: vapor diffusion, hanging drop / pH: 6.5 Details: 1.8 M ammonium sulfate, 6-8% dioxane, and 0.1 M MES , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
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