登録情報 | データベース: PDB / ID: 1uj3 |
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タイトル | Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor |
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要素 | - IgG Fab heavy chain
- IgG Fab light chain
- tissue factor
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キーワード | IMMUNE SYSTEM/BLOOD CLOTTING / tissue factor / antigen / antibody / Fab / IMMUNE SYSTEM-BLOOD CLOTTING COMPLEX |
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機能・相同性 | 機能・相同性情報
activation of blood coagulation via clotting cascade / activation of plasma proteins involved in acute inflammatory response / serine-type peptidase complex / positive regulation of platelet-derived growth factor receptor signaling pathway / NGF-stimulated transcription / positive regulation of positive chemotaxis / Extrinsic Pathway of Fibrin Clot Formation / cytokine receptor activity / positive regulation of TOR signaling / positive regulation of endothelial cell proliferation ...activation of blood coagulation via clotting cascade / activation of plasma proteins involved in acute inflammatory response / serine-type peptidase complex / positive regulation of platelet-derived growth factor receptor signaling pathway / NGF-stimulated transcription / positive regulation of positive chemotaxis / Extrinsic Pathway of Fibrin Clot Formation / cytokine receptor activity / positive regulation of TOR signaling / positive regulation of endothelial cell proliferation / positive regulation of interleukin-8 production / protein processing / phospholipid binding / cytokine-mediated signaling pathway / positive regulation of angiogenesis / activation of cysteine-type endopeptidase activity involved in apoptotic process / blood coagulation / collagen-containing extracellular matrix / protease binding / positive regulation of cell migration / external side of plasma membrane / positive regulation of gene expression / cell surface / extracellular space / membrane / plasma membrane類似検索 - 分子機能 Tissue factor / Tissue factor, conserved site / Tissue factor signature. / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold ...Tissue factor / Tissue factor, conserved site / Tissue factor signature. / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Ohto, U. / Mizutani, R. / Nakamura, M. / Adachi, H. / Satow, Y. |
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引用 | ジャーナル: J.Synchrotron Radiat. / 年: 2004 タイトル: Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor. 著者: Ohto, U. / Mizutani, R. / Nakamura, M. / Adachi, H. / Satow, Y. |
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履歴 | 登録 | 2003年7月25日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2004年7月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2019年11月6日 | Group: Data collection / Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_DOI |
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改定 1.4 | 2023年10月25日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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