[English] 日本語
![](img/lk-miru.gif)
- PDB-1shc: SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 1shc | ||||||
---|---|---|---|---|---|---|---|
Title | SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | ||||||
![]() |
| ||||||
![]() | COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) / PHOSPHOTYROSINE BINDING DOMAIN (PTB) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) complex | ||||||
Function / homology | ![]() regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / behavioral response to formalin induced pain / neurotrophin p75 receptor binding / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling / programmed cell death involved in cell development / Signalling to STAT3 ...regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / behavioral response to formalin induced pain / neurotrophin p75 receptor binding / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling / programmed cell death involved in cell development / Signalling to STAT3 / neurotrophin receptor activity / mechanoreceptor differentiation / nerve growth factor receptor activity / neurotrophin binding / Sertoli cell development / axonogenesis involved in innervation / GPI-linked ephrin receptor activity / nerve growth factor signaling pathway / Retrograde neurotrophin signalling / XBP1(S) activates chaperone genes / nerve growth factor binding / NGF-independant TRKA activation / sympathetic nervous system development / Signalling to p38 via RIT and RIN / neurotrophin TRKA receptor binding / ARMS-mediated activation / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / positive regulation of Ras protein signal transduction / positive regulation of programmed cell death / positive regulation of synapse assembly / Interleukin-2 signaling / Shc-EGFR complex / PI3K/AKT activation / epidermal growth factor binding / epidermal growth factor receptor binding / Signaling by ALK / Frs2-mediated activation / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / detection of temperature stimulus involved in sensory perception of pain / neurotrophin TRK receptor signaling pathway / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / response to axon injury / neuron development / Signalling to RAS / SHC-related events triggered by IGF1R / Role of LAT2/NTAL/LAB on calcium mobilization / Signal attenuation / Interleukin receptor SHC signaling / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / detection of mechanical stimulus involved in sensory perception of pain / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / response to electrical stimulus / SHC-mediated cascade:FGFR1 / Erythropoietin activates RAS / peptidyl-tyrosine autophosphorylation / Signaling by CSF3 (G-CSF) / Tie2 Signaling / SHC1 events in EGFR signaling / ephrin receptor binding / phosphotyrosine residue binding / transmembrane receptor protein tyrosine kinase activity / SHC1 events in ERBB2 signaling / Integrin signaling / Constitutive Signaling by Overexpressed ERBB2 / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / negative regulation of angiogenesis / positive regulation of synaptic transmission, glutamatergic / response to nutrient levels / B cell differentiation / insulin-like growth factor receptor signaling pathway / cellular response to nerve growth factor stimulus / positive regulation of GTPase activity / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / axon guidance / insulin-like growth factor receptor binding / Constitutive Signaling by EGFRvIII / insulin receptor binding / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor protein-tyrosine kinase / phospholipid binding / receptor tyrosine kinase binding / cellular response to growth factor stimulus / kinase binding / positive regulation of neuron projection development / cell-cell adhesion / cellular response to nicotine / circadian rhythm / peptidyl-tyrosine phosphorylation / recycling endosome membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Zhou, M.-M. / Ravichandran, K.S. / Olejniczak, E.T. / Petros, A.M. / Meadows, R.P. / Sattler, M. / Harlan, J.E. / Wade, W.S. / Burakoff, S.J. / Fesik, S.W. | ||||||
![]() | ![]() Title: Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Authors: Zhou, M.M. / Ravichandran, K.S. / Olejniczak, E.F. / Petros, A.M. / Meadows, R.P. / Sattler, M. / Harlan, J.E. / Wade, W.S. / Burakoff, S.J. / Fesik, S.W. #1: ![]() Title: Structural Basis for Il-4 Receptor Phosphopeptide Recognition by the Irs-1 Ptb Domain Authors: Zhou, M.M. / Huang, B. / Olejniczak, E.T. / Meadows, R.P. / Shuker, S.B. / Miyazaki, M. / Trub, T. / Shoelson, S.E. / Fesik, S.W. #2: ![]() Title: Specificity of the Ptb Domain of Shc for Beta Turn-Forming Pentapeptide Motifs Amino-Terminal to Phosphotyrosine Authors: Trub, T. / Choi, W.E. / Wolf, G. / Ottinger, E. / Chen, Y. / Weiss, M. / Shoelson, S.E. #3: ![]() Title: An Alternative to Sh2 Domains for Binding Tyrosine-Phosphorylated Proteins Authors: Kavanaugh, W.M. / Williams, L.T. | ||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 80.6 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 64.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 261.6 KB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 261.4 KB | Display | |
Data in XML | ![]() | 7.5 KB | Display | |
Data in CIF | ![]() | 9.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-
Links
-
Assembly
Deposited unit | ![]()
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-
Components
#1: Protein | Mass: 21409.584 Da / Num. of mol.: 1 / Fragment: PTB DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
---|---|
#2: Protein/peptide | Mass: 1514.508 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source References: UniProt: P04629 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-
Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
---|
-
Processing
Software |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
NMR software | Name: ![]() | ||||||||
Refinement | Software ordinal: 1 Details: SET OF IDEAL BOND LENGTHS AND ANGLES WERE USED DURING REFINEMENT: PARALLHDG.PRO IN X-PLOR. | ||||||||
NMR ensemble | Conformers submitted total number: 1 |