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- PDB-1qjx: HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOU... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1qjx | ||||||
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Title | HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND WIN68934 | ||||||
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![]() | VIRUS / NUCLEOTIDYLTRANSFERASE / RHINOVIRUS COAT PROTEIN / RNA-BINDING / TRANSFERASE / LIPOPROTEIN / WIN COMPOUND / PHOSPHOPROTEIN / THIOL PROTEASE / CAPSID PROTEIN / DRUG / VIRION / MEMBRANE / HELICASE / PROTEASE / NUCLEOTIDE-BINDING / HUMAN RHINOVIRUS 16 / RNA REPLICATION / ANTIVIRAL COMPOUND / COVALENT PROTEIN-RNA LINKAGE / MYRISTATE / HYDROLASE / CYTOPLASM / ATP-BINDING / CYTOPLASMIC VESICLE / HOST-VIRUS INTERACTION / RNA-DIRECTED RNA POLYMERASE | ||||||
Function / homology | ![]() symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase ...symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / DNA replication / RNA helicase activity / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Hadfield, A.T. / Diana, G.D. / Rossmann, M.G. | ||||||
![]() | ![]() Title: Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Authors: Hadfield, A.T. / Minor, I. / Diana, G.D. / Rossmann, M.G. #1: ![]() Title: The Refined Structure of Human Rhinovirus 16 at 2.15 Angstroms Resolution: Implications for the Viral Life Cycle Authors: Hadfield, A.T. / Lee, W.M. / Zhao, R. / Oliveira, M.A. / Minor, I. / Rueckert, R.R. / Rossmann, M.G. #2: ![]() Title: The Structure of Human Rhinovirus 16 Authors: Oliveira, M.A. / Zhao, R. / Lee, W.M. / Kremer, M.J. / Minor, I. / Rueckert, R.R. / Diana, G.D. / Pevear, D.C. / Dutko, F.J. / Mckinlay, M.A. / Rossmann, M.G. #3: ![]() Title: A Comparison of the Anti-Rhinoviral Drug Binding Pocket in Hrv14 and Hrv1A Authors: Kim, K.H. / Willingmann, P. / Gong, Z.X. / Kremer, M.J. / Chapman, M.S. / Minor, I. / Oliveira, M.A. / Rossmann, M.G. / Andries, K. / Diana, G.D. / Dutko, F.J. / Mckinlay, M.A. / Pevear, D.C. #4: ![]() Title: Crystal Structure of Human Rhinovirus Serotype 1A (Hrv1A) Authors: Kim, S.S. / Smith, T.J. / Chapman, M.S. / Rossmann, M.G. / Pevear, D.C. / Dutko, F.J. / Felock, P.J. / Diana, G.D. / Mckinlay, M.A. #5: Journal: Science / Year: 1986 Title: The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating Authors: Smith, T.J. / Kremer, M.J. / Luo, M. / Vriend, G. / Arnold, E. / Kamer, G. / Rossmann, M.G. / Mckinlay, M.A. / Diana, G.D. / Otto, M.J. #6: Journal: Nature / Year: 1985 Title: Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses Authors: Rossmann, M.G. / Arnold, E. / Erickson, J.W. / Frankenberger, E.A. / Griffith, J.P. / Hecht, H.J. / Johnson, J.E. / Kamer, G. / Luo, M. / Mosser, A.G. / Rueckert, R.R. / Sherry, B. / Vriend, G. | ||||||
History |
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Remark 285 | THE VIRION IS ORIENTED WITH ITS TWO FOLD ALONG THE CRYSTALLOGRAPHIC TWO FOLD AXIS IN P 2 21 21. ... THE VIRION IS ORIENTED WITH ITS TWO FOLD ALONG THE CRYSTALLOGRAPHIC TWO FOLD AXIS IN P 2 21 21. SPACE GROUP P 2 21 21 WAS USED SO THAT THE VIRAL TWO-FOLD COINCIDES WITH THE X AXIS. THE COORDINATES ARE IN THE P,Q,R FRAME IN ANGSTROM UNITS AND CORRESPOND TO ICOSAHEDRAL SYMMETRY AXES. THE ORIGIN IS CHOSEN AT THE CENTRE OF THE VIRUS WITH P, Q AND R ALONG MUTUALLY PERPENDICULAR TWO-FOLD AXES OF THE ICOSAHEDRON. THEY SHOULD REMAIN IN THAT FRAME FOR THE EASE OF THE USER IN CREATING THE BIOLOGICALLY SIGNIFICANT VIRAL PARTICLE USING THE 60 ICOSAHEDRAL SYMMETRY OPERATORS. THE GIVEN ORIGX PUTS THE CENTRE OF THE VIRION AT THE ORIGIN, WITH A NON CRYSTALLOGRAPHIC TWO FOLD AXIS ALONG X TO CORRESPOND TO THE CRYSTALLOGRAPHIC TWO FOLD. THE ORIENTATION CORRESPONDS TO THAT GIVEN IN OTHER RHINOVIRUS STRUCTURES. |
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-Validation report
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-Related structure data
Related structure data | ![]() 1qjuC ![]() 1qjyC ![]() 1aymS C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Assembly
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Symmetry | Point symmetry: (Schoenflies symbol: I (icosahedral)) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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