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- PDB-1mec: CONFORMATIONAL VARIABILITY OF A PICORNAVIRUS CAPSID: PH-DEPENDENT... -

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Basic information

Entry
Database: PDB / ID: 1mec
TitleCONFORMATIONAL VARIABILITY OF A PICORNAVIRUS CAPSID: PH-DEPENDENT STRUCTURAL CHANGES OF MENGO VIRUS RELATED TO ITS HOST RECEPTOR ATTACHMENT SITE AND DISASSEMBLY
Components(MENGO VIRUS COAT PROTEIN (SUBUNIT ...) x 4
KeywordsVIRUS / CARDIO PICORNAVIRUS COAT PROTEIN / Icosahedral virus
Function / homology
Function and homology information


positive stranded viral RNA replication / host cell nucleolus / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / channel activity / monoatomic ion transmembrane transport / RNA helicase activity / RNA helicase ...positive stranded viral RNA replication / host cell nucleolus / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / channel activity / monoatomic ion transmembrane transport / RNA helicase activity / RNA helicase / symbiont-mediated suppression of host gene expression / symbiont entry into host cell / viral translational frameshifting / symbiont-mediated activation of host autophagy / RNA-directed RNA polymerase / cysteine-type endopeptidase activity / RNA-directed RNA polymerase activity / DNA-templated transcription / virion attachment to host cell / structural molecule activity / ATP hydrolysis activity / proteolysis / RNA binding / zinc ion binding / ATP binding / membrane
Similarity search - Function
Leader peptide, picornavirus / Viral leader polypeptide zinc finger / Virion protein N terminal domain / Foot-And-Mouth Disease Virus, subunit 4 / Capsid protein VP4 superfamily, Picornavirus / Capsid protein VP4, Picornavirus / Viral protein VP4 subunit / Capsid protein VP4 superfamily, Picornavirus / Helicase/polymerase/peptidase polyprotein, Calicivirus-type / Jelly Rolls - #20 ...Leader peptide, picornavirus / Viral leader polypeptide zinc finger / Virion protein N terminal domain / Foot-And-Mouth Disease Virus, subunit 4 / Capsid protein VP4 superfamily, Picornavirus / Capsid protein VP4, Picornavirus / Viral protein VP4 subunit / Capsid protein VP4 superfamily, Picornavirus / Helicase/polymerase/peptidase polyprotein, Calicivirus-type / Jelly Rolls - #20 / Picornavirus coat protein / Peptidase C3A/C3B, picornaviral / 3C cysteine protease (picornain 3C) / Picornavirales 3C/3C-like protease domain / Picornavirales 3C/3C-like protease domain profile. / Picornavirus capsid / picornavirus capsid protein / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Picornavirus/Calicivirus coat protein / Few Secondary Structures / Irregular / Viral coat protein subunit / RNA-directed RNA polymerase, C-terminal domain / Viral RNA-dependent RNA polymerase / Reverse transcriptase/Diguanylate cyclase domain / Jelly Rolls / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Sandwich / Mainly Beta
Similarity search - Domain/homology
PHOSPHATE ION / Genome polyprotein
Similarity search - Component
Biological speciesMengo virus
MethodX-RAY DIFFRACTION / Resolution: 3.2 Å
AuthorsRossmann, M.G.
Citation
Journal: Virology / Year: 1990
Title: Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly.
Authors: Kim, S. / Boege, U. / Krishnaswamy, S. / Minor, I. / Smith, T.J. / Luo, M. / Scraba, D.G. / Rossmann, M.G.
#1: Journal: J.Mol.Biol. / Year: 1990
Title: Structural Refinement and Analysis of Mengo Virus
Authors: Krishnaswamy, S. / Rossmann, M.G.
#2: Journal: Acta Crystallogr.,Sect.B / Year: 1989
Title: Structure Determination of Mengo Virus
Authors: Luo, M. / Vriend, G. / Kamer, G. / Rossmann, M.G.
#3: Journal: Science / Year: 1987
Title: The Atomic Structure of Mengo Virus at 3.0 Angstroms Resolution
Authors: Luo, M. / Vriend, G. / Kamer, G. / Minor, I. / Arnold, E. / Rossmann, M.G. / Boege, U. / Scraba, D.G. / Duke, G.M. / Palmenberg, A.C.
#4: Journal: Proc.Natl.Acad.Sci.USA / Year: 1987
Title: Implications of the Picornavirus Capsid Structure for Polyprotein Processing
Authors: Arnold, E. / Luo, M. / Vriend, G. / Rossmann, M.G. / Palmenberg, A.C. / Parks, G.D. / Nicklin, M.J.H. / Wimmer, E.
#5: Journal: Chem.Scr. / Year: 1986
Title: The Structure of a Human Common Cold Virus (Rhinovirus 14) and its Evolutionary Relations to Other Viruses
Authors: Rossmann, M.G. / Arnold, E. / Erickson, J.W. / Frankenberger, E.A. / Griffith, J.P. / Hecht, H.-J. / Johnson, J.E. / Kamer, G. / Luo, M. / Vriend, G. / Mosser, A.G. / Palmenberg, A.C. / ...Authors: Rossmann, M.G. / Arnold, E. / Erickson, J.W. / Frankenberger, E.A. / Griffith, J.P. / Hecht, H.-J. / Johnson, J.E. / Kamer, G. / Luo, M. / Vriend, G. / Mosser, A.G. / Palmenberg, A.C. / Rueckert, R.R. / Sherry, B.
#6: Journal: Nature / Year: 1985
Title: Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses
Authors: Rossmann, M.G. / Arnold, E. / Erickson, J.W. / Frankenberger, E.A. / Griffith, J.P. / Hecht, H.-J. / Johnson, J.E. / Kamer, G. / Luo, M. / Mosser, A.G. / Rueckert, R.R. / Sherry, B. / Vriend, G.
#7: Journal: J.Mol.Biol. / Year: 1984
Title: Picornaviruses of Two Different Genera Have Similar Structures
Authors: Luo, M. / Arnold, E. / Erickson, J.W. / Rossmann, M.G. / Boege, U. / Scraba, D.G.
History
DepositionJan 17, 1992Processing site: BNL
Revision 1.0Jan 31, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 2.0Apr 19, 2023Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Database references / Derived calculations / Other / Refinement description
Category: atom_site / cell ...atom_site / cell / database_2 / database_PDB_matrix / pdbx_database_remark / pdbx_struct_oper_list / pdbx_validate_close_contact / pdbx_validate_main_chain_plane / pdbx_validate_peptide_omega / pdbx_validate_rmsd_angle / pdbx_validate_rmsd_bond / pdbx_validate_torsion / struct_ncs_oper / struct_ref_seq_dif / struct_site
Item: _atom_site.Cartn_x / _atom_site.Cartn_y ..._atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _cell.Z_PDB / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _database_PDB_matrix.origx[1][1] / _database_PDB_matrix.origx[1][2] / _database_PDB_matrix.origx[1][3] / _database_PDB_matrix.origx[2][1] / _database_PDB_matrix.origx[2][2] / _database_PDB_matrix.origx[2][3] / _database_PDB_matrix.origx[3][1] / _database_PDB_matrix.origx[3][2] / _database_PDB_matrix.origx[3][3] / _database_PDB_matrix.origx_vector[1] / _database_PDB_matrix.origx_vector[2] / _database_PDB_matrix.origx_vector[3] / _pdbx_struct_oper_list.id / _pdbx_struct_oper_list.matrix[1][1] / _pdbx_struct_oper_list.matrix[1][2] / _pdbx_struct_oper_list.matrix[1][3] / _pdbx_struct_oper_list.matrix[2][1] / _pdbx_struct_oper_list.matrix[2][2] / _pdbx_struct_oper_list.matrix[2][3] / _pdbx_struct_oper_list.matrix[3][1] / _pdbx_struct_oper_list.matrix[3][2] / _pdbx_struct_oper_list.matrix[3][3] / _pdbx_struct_oper_list.name / _pdbx_struct_oper_list.symmetry_operation / _pdbx_struct_oper_list.type / _pdbx_struct_oper_list.vector[1] / _pdbx_struct_oper_list.vector[2] / _pdbx_struct_oper_list.vector[3] / _pdbx_validate_close_contact.dist / _pdbx_validate_main_chain_plane.improper_torsion_angle / _pdbx_validate_peptide_omega.omega / _pdbx_validate_rmsd_bond.bond_deviation / _pdbx_validate_rmsd_bond.bond_value / _pdbx_validate_torsion.phi / _pdbx_validate_torsion.psi / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Details: Coordinates and associated matrices have been transformed from the icosahedral point symmetry frame to the crystallographic frame
Provider: repository / Type: Remediation
Revision 2.1Oct 23, 2024Group: Data collection / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature
Item: _pdbx_entry_details.has_protein_modification
Remark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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
1: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
2: MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)
3: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
4: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
hetero molecules


Theoretical massNumber of molelcules
Total (without water)91,7796
Polymers91,5894
Non-polymers1902
Water5,332296
1
1: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
2: MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)
3: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
4: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
hetero molecules
x 60


Theoretical massNumber of molelcules
Total (without water)5,506,717360
Polymers5,495,320240
Non-polymers11,397120
Water4,324240
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
point symmetry operation59
2


  • Idetical with deposited unit
  • icosahedral asymmetric unit
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
1: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
2: MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)
3: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
4: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
hetero molecules
x 5


  • icosahedral pentamer
  • 459 kDa, 20 polymers
Theoretical massNumber of molelcules
Total (without water)458,89330
Polymers457,94320
Non-polymers95010
Water36020
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
point symmetry operation4
4
1: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
2: MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)
3: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
4: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
hetero molecules
x 6


  • icosahedral 23 hexamer
  • 551 kDa, 24 polymers
Theoretical massNumber of molelcules
Total (without water)550,67236
Polymers549,53224
Non-polymers1,14012
Water43224
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
point symmetry operation5
5


  • Idetical with deposited unit in distinct coordinate
  • icosahedral asymmetric unit, std point frame
TypeNameSymmetry operationNumber
transform to point frame1
6
1: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
2: MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)
3: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
4: MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)
hetero molecules
x 60


  • crystal asymmetric unit, crystal frame
  • 5.51 MDa, 240 polymers
Theoretical massNumber of molelcules
Total (without water)5,506,717360
Polymers5,495,320240
Non-polymers11,397120
Water4,324240
TypeNameSymmetry operationNumber
identity operation1_555x,y,z2
point symmetry operation59
Unit cell
Length a, b, c (Å)439.800, 426.900, 421.200
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number19
Space group name H-MP212121
Atom site foot note1: CIS PROLINE - PRO 1 105
2: VAL 1 273 - LEU 1 274 OMEGA =214.52 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
3: GLU 2 5 - GLU 2 6 OMEGA =146.36 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
4: ASP 2 12 - ARG 2 13 OMEGA =239.28 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
5: CIS PROLINE - PRO 2 85 / 6: CIS PROLINE - PRO 2 152 / 7: CIS PROLINE - PRO 3 59
8: ASN 4 9 - ASN 4 10 OMEGA = 92.19 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
9: SER 4 11 - SER 4 12 OMEGA =222.33 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
SymmetryPoint symmetry: (Hermann–Mauguin notation: 532 / Schoenflies symbol: I (icosahedral))
Noncrystallographic symmetry (NCS)NCS oper:
IDCodeMatrixVector
1given(1), (1), (1)
2generate(0.98601057, -0.140196, 0.09110716), (0.13012006, 0.30903087, -0.9420652), (0.10326766, 0.94070311, 0.32299254)7.24875, 158.84603, -42.82487
3generate(0.96338296, -0.09585486, 0.25133333), (0.07122602, -0.80894589, -0.58355239), (0.25758203, 0.58006867, -0.77247106)-11.77514, 249.22139, 93.51853
4generate(0.96338776, 0.07174549, 0.25925139), (-0.09529258, -0.80892441, 0.5800859), (0.24968591, -0.58351877, -0.77249733)-30.7813, 146.2304, 220.60826
5generate(0.98601832, 0.13098704, 0.10391885), (-0.13931267, 0.30906563, 0.94074112), (0.09049145, -0.94202093, 0.32295003)-23.50386, -7.79689, 162.81063
6generate(0.17733553, -0.01901109, 0.98453853), (-0.0190152, -0.99969295, -0.01590132), (0.98339536, -0.01587944, -0.17764258)-9.30638, 220.67181, 15.38989
7generate(0.27405197, 0.8954217, 0.35206482), (-0.15047138, -0.32122855, 0.93490751), (0.94922725, -0.30988426, 0.04717659)-53.20349, 62.41768, 27.60342
8generate(0.42308738, 0.56948043, -0.70486321), (-0.09361895, 0.80129634, 0.59087737), (0.90049777, -0.18446252, 0.39365026)75.9401, -29.73622, -16.76009
9generate(0.41847989, -0.54639515, -0.72560696), (0.07297398, 0.81659049, -0.57255378), (0.90454939, 0.18705722, 0.3829636)199.65234, 71.56366, -56.39177
10generate(0.26659689, -0.91010291, 0.31850073), (0.11908163, -0.2964821, -0.94756363), (0.95578291, 0.29124729, 0.02988521)146.96712, 226.32433, -36.52199
11generate(-0.17738267, 0.00930007, -0.98466987), (0.00930968, -0.99989475, -0.01114366), (-0.9835264, -0.01111922, 0.17727741)232.64796, 217.04908, 196.40981
12generate(-0.27537561, -0.89853965, -0.34296313), (-0.1220777, -0.3207864, 0.9392149), (-0.95290724, 0.30121571, -0.02187198)275.0078, 58.76447, 179.92234
13generate(-0.4238583, -0.56169641, 0.71061971), (-0.06512014, 0.80150428, 0.59443896), (-0.90264108, 0.20610371, -0.37764599)144.96956, -33.29785, 221.79854
14generate(-0.4176327, 0.55432389, 0.72006298), (0.10146897, 0.81600973, -0.56900286), (-0.90219404, -0.16501368, -0.39837702)22.24168, 68.08912, 264.16692
15generate(-0.26530239, 0.90721912, -0.3276836), (0.14746912, -0.2973161, -0.9432735), (-0.95218391, -0.29926482, -0.0554155)76.42991, 222.81203, 248.47582
16generate(-0.99995287, 0.00971102, 0.00013134), (0.00970552, 0.9995877, 0.02704498), (0.00013104, 0.02699865, -0.99963484)221.19705, -3.85764, 205.83746
17generate(-0.98468693, 0.14331396, -0.10020885), (0.14242902, 0.33298408, -0.93205722), (-0.09958767, -0.93203455, -0.34829715)215.48558, 153.83505, 252.93627
18generate(-0.96261205, 0.08807084, -0.25708983), (0.08751307, -0.79385474, -0.60176394), (-0.25543872, -0.60170987, 0.75646678)235.40411, 247.67592, 119.08017
19generate(-0.96423494, -0.07967423, -0.25370741), (-0.07915037, -0.82367581, 0.56147073), (-0.25204125, 0.56147522, 0.78791075)253.42592, 147.98006, -10.74626
20generate(-0.98731283, -0.12810325, -0.09473598), (-0.12723808, 0.28473257, 0.95009601), (-0.09409045, 0.95003846, -0.29741974)244.64548, -7.47623, 42.87269
21generate(0.48480586, -0.63619187, -0.60029567), (-0.77514066, 0.0050346, -0.6321295), (0.40402499, 0.77216236, -0.48984047)188.93744, 260.06491, 26.89879
22generate(0.33325125, -0.82927077, 0.44961248), (-0.82892031, -0.48441872, -0.2795369), (0.44826204, -0.27881513, -0.84883254)117.1027, 282.3167, 173.45975
23generate(0.26711492, 0.11996109, 0.95681018), (-0.90922391, -0.29645024, 0.29054511), (0.31805473, -0.94750644, 0.02933533)-31.46261, 211.33121, 168.77156
24generate(0.37779503, 0.89969755, 0.22036746), (-0.9050746, 0.30917397, 0.29028256), (0.19334512, -0.3098029, 0.93106499)-51.4463, 145.20797, 19.31313
25generate(0.51233543, 0.43236933, -0.74197688), (-0.82220659, 0.49550186, -0.27996171), (0.24647766, 0.75301086, 0.6101967)84.76843, 175.32705, -68.36906
26generate(-0.49225735, 0.63631219, 0.59406441), (-0.75918893, 0.01974107, -0.65094278), (-0.42474167, -0.77182784, 0.47251628)34.79755, 258.66126, 185.99465
27generate(-0.34122633, 0.82449086, -0.45241736), (-0.81322094, -0.49980804, -0.29801458), (-0.47043442, 0.26552599, 0.84103437)106.86424, 284.17042, 40.07857
28generate(-0.27589005, -0.12295872, -0.95393974), (-0.89765477, -0.32078902, 0.30050502), (-0.34245141, 0.9391724, -0.02135491)254.73259, 211.64549, 42.82907
29generate(-0.38654103, -0.89669344, -0.21741585), (-0.89580573, 0.30939991, 0.31748228), (-0.2176608, 0.31815496, -0.92285889)274.05358, 141.31346, 190.44505
30generate(-0.52026337, -0.42743821, 0.73930334), (-0.81022914, 0.51985909, -0.27054479), (-0.26851899, -0.73930134, -0.6176297)138.12625, 170.3708, 278.92625
31generate(0.49848774, 0.64730845, -0.57670309), (0.75925944, -0.00521415, 0.65113926), (0.41729258, -0.76287699, -0.49327359)45.73772, -43.33366, 192.28204
32generate(0.51618722, -0.41235408, -0.75066176), (0.81520099, 0.50447225, 0.28439916), (0.26125009, -0.75827929, 0.59737451)176.87075, -66.54318, 95.25128
33generate(0.37779144, -0.90594738, 0.19303463), (0.898808, 0.30914474, -0.3091163), (0.22061747, 0.29099413, 0.9310978)147.25864, 7.32007, -48.88713
34generate(0.27455865, -0.15134228, 0.95022974), (0.89453841, -0.32126068, -0.30918892), (0.35154762, 0.93488307, 0.04670203)-2.17567, 76.17958, -40.93881
35generate(0.34915307, 0.80862261, 0.47450567), (0.80829265, -0.51554517, 0.28428165), (0.47309952, 0.28355491, -0.8336079)-64.91905, 44.87386, 108.11193
36generate(-0.49103625, -0.64742878, 0.58293434), (0.77507015, -0.01956153, 0.63193302), (-0.3965759, 0.76254247, 0.51059777)175.06593, -41.52927, 12.46168
37generate(-0.50821214, 0.41713399, 0.75346665), (0.82694025, 0.4797545, 0.29315232), (-0.23907772, 0.77156843, -0.58957635)43.70095, -66.0807, 108.84756
38generate(-0.36901631, 0.90894501, -0.19590507), (0.90807068, 0.30809453, -0.28193383), (-0.19622079, -0.28266009, -0.93907822)74.01002, 3.56647, 254.92367
39generate(-0.26581266, 0.14833817, -0.95318136), (0.90634192, -0.29731319, -0.29857592), (-0.32723194, -0.94323513, -0.05490814)224.10703, 71.16222, 248.81778
40generate(-0.34122513, -0.81355372, -0.47183213), (0.82414307, -0.49981578, 0.26622485), (-0.45105819, -0.29726442, 0.8410409)286.56302, 43.29153, 98.96803
41generate(0.48564046, -0.77515824, 0.4051779), (-0.63509137, 0.00505692, 0.77177367), (-0.60056855, -0.63138625, -0.49069738)98.937, 97.91763, 290.87046
42generate(0.41982476, 0.07351943, 0.90536436), (-0.54584954, 0.8166099, 0.18665182), (-0.72499612, -0.57252108, 0.38159933)-38.02522, 61.06617, 207.23794
43generate(0.51701286, 0.81554108, 0.26141488), (-0.41268099, 0.50446755, -0.75874342), (-0.74994346, 0.28368655, 0.59655358)-62.07585, 178.83135, 94.69797
44generate(0.64289411, 0.42545803, -0.63675424), (-0.41962013, -0.50000003, -0.75790797), (-0.64093418, 0.75398679, -0.14289408)60.02225, 288.46569, 108.77697
45generate(0.62350489, -0.55764822, -0.54790382), (-0.5570773, -0.80865276, 0.18800361), (-0.54861541, 0.18844071, -0.81485213)159.53367, 238.45826, 230.01823
46generate(0.49931116, 0.75925368, 0.41848094), (0.64623821, -0.00523691, -0.7624522), (-0.57704573, 0.65040184, -0.49407425)-70.40248, 116.82146, 149.57865
47generate(0.63433576, 0.55829771, -0.53460943), (0.55777963, -0.80945953, -0.18245593), (-0.53536475, -0.18288342, -0.82487623)35.89995, 153.32594, 269.86821
48generate(0.64289964, -0.41930886, -0.64083517), (0.42580789, -0.49998333, 0.75444947), (-0.63685514, -0.75742425, -0.14291632)152.07605, 36.60336, 272.2624
49generate(0.5131678, -0.82254699, 0.24660407), (0.43270345, 0.49550611, 0.75349258), (-0.74126063, -0.27922476, 0.60936007)117.5744, -72.03964, 153.45253
50generate(0.42442524, -0.09415529, 0.90129743), (0.56893688, 0.80127621, -0.1840042), (-0.70429638, 0.59085962, 0.39233253)-19.92489, -22.46212, 77.6298
51generate(-0.49186383, 0.77508788, -0.39772854), (-0.64635849, -0.0195443, 0.76211702), (0.58326627, 0.63119064, 0.51140814)123.2538, 102.84643, -82.27017
52generate(-0.42520095, -0.06566104, -0.90345899), (-0.56115737, 0.80150294, 0.20568223), (0.71004919, 0.59436902, -0.37630199)259.84071, 62.41904, 0.31892
53generate(-0.52109454, -0.81056649, -0.26869238), (-0.42777517, 0.51984709, -0.73975965), (0.73859553, -0.26985614, -0.61678654)285.01905, 176.8586, 115.99414
54generate(-0.64702293, -0.43019445, 0.6293454), (-0.43054155, -0.47527303, -0.76764008), (0.6294552, -0.76715503, 0.12229596)163.99322, 288.01353, 104.89626
55generate(-0.62895735, 0.54979384, 0.54959667), (-0.56563347, -0.80863524, 0.16057075), (0.53345644, -0.21027751, 0.81955862)64.01679, 242.27149, -17.63782
56generate(-0.49308778, -0.75918332, -0.42593029), (0.63521165, 0.01972429, -0.77143849), (0.59434801, -0.65020623, 0.47336348)292.75032, 116.27771, 59.45823
57generate(-0.62895957, -0.56615609, 0.53270405), (0.54922728, -0.80865331, -0.20987812), (0.55031168, 0.16103548, 0.81957889)186.8232, 157.05208, -59.78791
58generate(-0.63881796, 0.41433427, 0.64811267), (0.41464827, -0.52433131, 0.74405361), (0.64820307, 0.74359384, 0.16314928)69.51939, 41.56993, -65.31735
59generate(-0.50903898, 0.82728341, -0.23919523), (0.41745823, 0.47976695, 0.77205547), (0.75273961, 0.292393, -0.58876195)102.94877, -70.57634, 50.5114
60generate(-0.41897278, 0.10200966, -0.90299028), (0.55377389, 0.8160118, -0.16457016), (0.71945534, -0.56902282, -0.39703902)240.91307, -24.40439, 127.62695

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Components

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MENGO VIRUS COAT PROTEIN (SUBUNIT ... , 4 types, 4 molecules 1234

#1: Protein MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)


Mass: 30273.971 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mengo virus / Genus: Cardiovirus / Species: Encephalomyocarditis virus / References: UniProt: P12296
#2: Protein MENGO VIRUS COAT PROTEIN (SUBUNIT VP2)


Mass: 28791.031 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mengo virus / Genus: Cardiovirus / Species: Encephalomyocarditis virus / References: UniProt: P12296
#3: Protein MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)


Mass: 25186.896 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mengo virus / Genus: Cardiovirus / Species: Encephalomyocarditis virus / References: UniProt: P12296
#4: Protein MENGO VIRUS COAT PROTEIN (SUBUNIT VP1)


Mass: 7336.771 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mengo virus / Genus: Cardiovirus / Species: Encephalomyocarditis virus / References: UniProt: P12296

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Non-polymers , 2 types, 298 molecules

#5: Chemical ChemComp-PO4 / PHOSPHATE ION


Mass: 94.971 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: PO4
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 296 / Source method: isolated from a natural source / Formula: H2O

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Details

Has protein modificationY
Sequence detailsNOTE THAT THERE ARE TWO SEQUENCE DIFFERENCES BETWEEN THE THE SEQUENCE PRESENTED IN THIS ENTRY AND ...NOTE THAT THERE ARE TWO SEQUENCE DIFFERENCES BETWEEN THE THE SEQUENCE PRESENTED IN THIS ENTRY AND THE SEQUENCE PRESENTED IN PROTEIN DATA BANK ENTRY 2MEV. RESIDUE 45 OF CHAIN 1 IS ARG IN THIS ENTRY AND ALA IN 2MEV. RESIDUE 58 OF CHAIN 3 IS MET IN THIS ENTRY AND VAL IN 2MEV. SEQUENCE ADVISORY NOTICE: DIFFERENCE BETWEEN SWISS-PROT AND PDB SEQUENCE. SWISS-PROT ENTRY NAME: POLG_ENMGO SWISS-PROT RESIDUE PDB SEQRES NAME NUMBER NAME CHAIN SEQ/INSERT CODE ALA 602 ARG 1 45 VAL 384 MET 3 58

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION

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Data collection

RadiationScattering type: x-ray
Radiation wavelengthRelative weight: 1

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Processing

RefinementHighest resolution: 3.2 Å
Refinement stepCycle: LAST / Highest resolution: 3.2 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6404 0 10 296 6710

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