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Yorodumi- PDB-3vdd: Structure of HRV2 capsid complexed with antiviral compound BTA798 -
+Open data
-Basic information
Entry | Database: PDB / ID: 3vdd | ||||||
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Title | Structure of HRV2 capsid complexed with antiviral compound BTA798 | ||||||
Components |
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Keywords | VIRUS / viral capsid / virus-drug complex | ||||||
Function / homology | Function and homology information symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase ...symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / symbiont-mediated suppression of host gene expression / DNA replication / RNA helicase activity / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | ||||||
Biological species | Human rhinovirus 2 | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.2 Å | ||||||
Authors | Morton, C.J. / Feil, S.C. / Parker, M.W. | ||||||
Citation | Journal: ACS Med Chem Lett / Year: 2012 Title: An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus. Authors: Feil, S.C. / Hamilton, S. / Krippner, G.Y. / Lin, B. / Luttick, A. / McConnell, D.B. / Nearn, R. / Parker, M.W. / Ryan, J. / Stanislawski, P.C. / Tucker, S.P. / Watson, K.G. / Morton, C.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3vdd.cif.gz | 179.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3vdd.ent.gz | 141.1 KB | Display | PDB format |
PDBx/mmJSON format | 3vdd.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3vdd_validation.pdf.gz | 633 KB | Display | wwPDB validaton report |
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Full document | 3vdd_full_validation.pdf.gz | 670.6 KB | Display | |
Data in XML | 3vdd_validation.xml.gz | 23.1 KB | Display | |
Data in CIF | 3vdd_validation.cif.gz | 33.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vd/3vdd ftp://data.pdbj.org/pub/pdb/validation_reports/vd/3vdd | HTTPS FTP |
-Related structure data
Related structure data | 1fpnS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Symmetry | Point symmetry: (Schoenflies symbol: I (icosahedral)) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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