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Open data
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Basic information
Entry | Database: PDB / ID: 1eah | |||||||||
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Title | PV2L COMPLEXED WITH ANTIVIRAL AGENT SCH48973 | |||||||||
![]() | (POLIOVIRUS TYPE 2 COAT PROTEINS VP1 TO ...) x 4 | |||||||||
![]() | VIRUS / TYPE 2 / LANSING / ANTIVIRAL / PICORNAVIRUS / MOUSE NEUROVIRULENCE / COAT PROTEIN / Icosahedral virus | |||||||||
Function / homology | ![]() symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity / picornain 2A / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane ...symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity / picornain 2A / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / symbiont-mediated suppression of host gene expression / DNA replication / receptor-mediated endocytosis of virus by host cell / RNA helicase activity / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() | |||||||||
![]() | Lentz, K. / Arnold, E. | |||||||||
![]() | ![]() Title: Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes. Authors: Lentz, K.N. / Smith, A.D. / Geisler, S.C. / Cox, S. / Buontempo, P. / Skelton, A. / DeMartino, J. / Rozhon, E. / Schwartz, J. / Girijavallabhan, V. / O'Connell, J. / Arnold, E. #1: ![]() Title: Structures of Poliovirus Complexes with Anti-Viral Drugs: Implications for Viral Stability and Drug Design Authors: Grant, R.A. / Hiremath, C.N. / Filman, D.J. / Syed, R. / Andries, K. / Hogle, J.M. #2: ![]() Title: Three Dimensional Structure-Activity Relationships for Antiviral Agents that Interact with Picornavirus Capsids Authors: Zhang, A. / Nanni, R. / Oren, D.A. / Rozhon, E.J. / Arnold, E. #3: ![]() Title: Three-Dimensional Structure of a Mouse-Adapted Type 2/Type 1 Poliovirus Chimera Authors: Yeates, T.O. / Jacobson, D.H. / Martin, A. / Wychowski, C. / Girard, M. / Filman, D.J. / Hogle, J.M. #4: ![]() Title: Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus Authors: Filman, D.J. / Syed, R. / Chow, M. / Macadam, A.J. / Minor, P.D. / Hogle, J.M. #5: ![]() Title: Three-Dimensional Structure of Poliovirus at 2.9 A Resolution Authors: Hogle, J.M. / Chow, M. / Filman, D.J. | |||||||||
History |
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Structure visualization
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PDBx/mmCIF format | ![]() | 181.3 KB | Display | ![]() |
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PDB format | ![]() | 144.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 684.8 KB | Display | ![]() |
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Full document | ![]() | 695.5 KB | Display | |
Data in XML | ![]() | 33.4 KB | Display | |
Data in CIF | ![]() | 47.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Assembly
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Symmetry | Point symmetry: (Hermann–Mauguin notation: 532 / Schoenflies symbol: I (icosahedral)) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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