+
データを開く
-
基本情報
登録情報 | データベース: PDB / ID: 1abo | ||||||
---|---|---|---|---|---|---|---|
タイトル | CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE | ||||||
![]() |
| ||||||
![]() | COMPLEX (KINASE/PEPTIDE) / SH3 DOMAIN / TRANSFERASE (PHOSPHOTRANSFERASE) / PROTO-ONCOGENE / COMPLEX (KINASE-PEPTIDE) COMPLEX | ||||||
機能・相同性 | ![]() regulation of actin filament depolymerization / small GTPase binding => GO:0031267 / Role of ABL in ROBO-SLIT signaling / HDR through Single Strand Annealing (SSA) / negative regulation of small GTPase mediated signal transduction / RHO GTPases Activate WASPs and WAVEs / semaphorin receptor binding / Cyclin D associated events in G1 / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / protein localization to cytoplasmic microtubule plus-end ...regulation of actin filament depolymerization / small GTPase binding => GO:0031267 / Role of ABL in ROBO-SLIT signaling / HDR through Single Strand Annealing (SSA) / negative regulation of small GTPase mediated signal transduction / RHO GTPases Activate WASPs and WAVEs / semaphorin receptor binding / Cyclin D associated events in G1 / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / protein localization to cytoplasmic microtubule plus-end / DNA conformation change / circulatory system development / podocyte apoptotic process / DN4 thymocyte differentiation / response to epinephrine / regulation of cellular senescence / transitional one stage B cell differentiation / RUNX1 regulates transcription of genes involved in differentiation of HSCs / regulation of modification of synaptic structure / Regulation of actin dynamics for phagocytic cup formation / delta-catenin binding / B cell proliferation involved in immune response / positive regulation of extracellular matrix organization / regulation of Rac protein signal transduction / neuroepithelial cell differentiation / ruffle assembly / microspike assembly / positive regulation of Wnt signaling pathway, planar cell polarity pathway / regulation of extracellular matrix organization / cerebellum morphogenesis / positive regulation of blood vessel branching / B-1 B cell homeostasis / regulation of blood vessel endothelial cell migration / neuropilin signaling pathway / neuropilin binding / Myogenesis / bubble DNA binding / cell junction assembly / filopodium assembly / activated T cell proliferation / establishment of epithelial cell apical/basal polarity / regulation of Cdc42 protein signal transduction / proline-rich region binding / positive regulation of dendrite development / negative regulation of mitotic cell cycle / mitogen-activated protein kinase binding / myoblast proliferation / syntaxin binding / negative regulation of BMP signaling pathway / alpha-beta T cell differentiation / cardiac muscle cell proliferation / regulation of T cell differentiation / regulation of axon extension / positive regulation of cell migration involved in sprouting angiogenesis / negative regulation of cell-cell adhesion / phagocytosis, engulfment / BMP signaling pathway / B cell proliferation / cell leading edge / positive regulation of osteoblast proliferation / regulation of microtubule polymerization / platelet-derived growth factor receptor-beta signaling pathway / negative regulation of cellular senescence / positive regulation of focal adhesion assembly / Bergmann glial cell differentiation / associative learning / positive regulation of vasoconstriction / semaphorin-plexin signaling pathway / phagocytic cup / platelet-derived growth factor receptor signaling pathway / neuromuscular process controlling balance / negative regulation of long-term synaptic potentiation / endothelial cell migration / bicellular tight junction / signal transduction in response to DNA damage / positive regulation of T cell migration / negative regulation of double-strand break repair via homologous recombination / negative regulation of endothelial cell apoptotic process / phagocytosis / canonical NF-kappaB signal transduction / four-way junction DNA binding / positive regulation of substrate adhesion-dependent cell spreading / spleen development / positive regulation of stress fiber assembly / cellular response to transforming growth factor beta stimulus / ruffle / positive regulation of establishment of T cell polarity / ERK1 and ERK2 cascade / positive regulation of interleukin-2 production / ephrin receptor binding / actin filament polymerization / phosphotyrosine residue binding / response to endoplasmic reticulum stress / substrate adhesion-dependent cell spreading / positive regulation of mitotic cell cycle / GTPase activator activity / SH2 domain binding / positive regulation of release of sequestered calcium ion into cytosol / post-embryonic development / positive regulation of GTPase activity 類似検索 - 分子機能 | ||||||
生物種 | ![]() ![]() | ||||||
手法 | ![]() | ||||||
![]() | Musacchio, A. / Wilmanns, M. / Saraste, M. | ||||||
![]() | ![]() タイトル: High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. 著者: Musacchio, A. / Saraste, M. / Wilmanns, M. #1: ![]() タイトル: Crystal Structure of the SH3 Domain in Human Fyn. Comparison of the Three-Dimensional Structures of the SH3 Domain in Tyrosine Kinases and Spectrin 著者: Noble, M.E.M. / Musacchio, A. / Courtneidge, S. / Saraste, M. / Wierenga, R. #2: ![]() タイトル: Identification of a Ten-Amino Acid SH3 Binding Site 著者: Ren, R. / Mayer, B. / Clark, K.L. / Baltimore, D. #3: ![]() タイトル: Crystal Structure of a Src-Homology 3 (SH3) Domain 著者: Musacchio, A. / Noble, M.E.M. / Pauptit, R. / Wierenga, R. / Saraste, M. | ||||||
履歴 |
|
-
構造の表示
構造ビューア | 分子: ![]() ![]() |
---|
-
ダウンロードとリンク
-
ダウンロード
PDBx/mmCIF形式 | ![]() | 40.9 KB | 表示 | ![]() |
---|---|---|---|---|
PDB形式 | ![]() | 28.7 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
---|
-関連構造データ
-
リンク
-
集合体
登録構造単位 | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 | ![]()
| ||||||||
2 | ![]()
| ||||||||
3 | ![]()
| ||||||||
単位格子 |
|
-
要素
#1: タンパク質 | 分子量: 6880.580 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() ![]() #2: タンパク質・ペプチド | 分子量: 1017.239 Da / 分子数: 2 / 由来タイプ: 組換発現 / 参照: UniProt: P55194 #3: 化合物 | #4: 水 | ChemComp-HOH / | |
---|
-実験情報
-実験
実験 | 手法: ![]() |
---|
-
試料調製
結晶 | マシュー密度: 2.01 Å3/Da / 溶媒含有率: 38.9 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
結晶化 | *PLUS pH: 8.2 / 手法: 蒸気拡散法, ハンギングドロップ法 / 詳細: used as seeds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
|
-データ収集
放射光源 | 波長: 1.5418 Å |
---|---|
検出器 | タイプ: MARRESEARCH / 検出器: IMAGE PLATE / 日付: 1993年12月20日 |
放射 | 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1.5418 Å / 相対比: 1 |
反射 | % possible obs: 89 % / Rmerge(I) obs: 0.029 |
反射 | *PLUS 最高解像度: 2 Å / Rmerge(I) obs: 0.029 |
-
解析
ソフトウェア |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
精密化 | 解像度: 2→8 Å / σ(F): 1 /
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 2→8 Å
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
拘束条件 |
|