登録情報 | データベース: PDB / ID: 7kcm |
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タイトル | Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP |
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要素 | - Heat shock protein 75 kDa, mitochondrial
- Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
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キーワード | CHAPERONE / Hsp90 / TRAP1 / SdhB / mitochondria |
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機能・相同性 | 機能・相同性情報
translational attenuation / negative regulation of cellular respiration / 酸化還元酵素; CH-OHの結合に対し酸化酵素として働く; キノンあるいはその類似化合物を用いる / : / mitochondrial electron transport, succinate to ubiquinone / Citric acid cycle (TCA cycle) / succinate dehydrogenase / succinate dehydrogenase (quinone) activity / Maturation of TCA enzymes and regulation of TCA cycle / tumor necrosis factor receptor binding ...translational attenuation / negative regulation of cellular respiration / 酸化還元酵素; CH-OHの結合に対し酸化酵素として働く; キノンあるいはその類似化合物を用いる / : / mitochondrial electron transport, succinate to ubiquinone / Citric acid cycle (TCA cycle) / succinate dehydrogenase / succinate dehydrogenase (quinone) activity / Maturation of TCA enzymes and regulation of TCA cycle / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / 3 iron, 4 sulfur cluster binding / ubiquinone binding / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / tricarboxylic acid cycle / respiratory electron transport chain / proton motive force-driven mitochondrial ATP synthesis / cell periphery / ATP-dependent protein folding chaperone / mitochondrial membrane / aerobic respiration / mitochondrial intermembrane space / 2 iron, 2 sulfur cluster binding / unfolded protein binding / protein folding / 4 iron, 4 sulfur cluster binding / electron transfer activity / mitochondrial inner membrane / mitochondrial matrix / protein kinase binding / ATP hydrolysis activity / mitochondrion / RNA binding / nucleoplasm / ATP binding / membrane / metal ion binding / plasma membrane類似検索 - 分子機能 : / 4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal ...: / 4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Beta-grasp domain superfamily / 2Fe-2S ferredoxin-type iron-sulfur binding domain profile. / 2Fe-2S ferredoxin-type iron-sulfur binding domain / 2Fe-2S ferredoxin-like superfamily / 4Fe-4S ferredoxin, iron-sulphur binding, conserved site / 4Fe-4S ferredoxin-type iron-sulfur binding region signature. / 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. / 4Fe-4S ferredoxin-type, iron-sulphur binding domain / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / FE2/S2 (INORGANIC) CLUSTER / : / Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial / Heat shock protein 75 kDa, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.43 Å |
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データ登録者 | Liu, Y.X. / Agard, D.A. |
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資金援助 | 米国, 6件 組織 | 認可番号 | 国 |
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Howard Hughes Medical Institute (HHMI) | | 米国 | American Heart Association | 18POST33990362 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM118099 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | U54CA209891 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | U01MH115747 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | U19AI135990 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates 著者: Liu, Y.X. / Agard, D.A. / Elnatan, D. / Sun, M. / Myasnikov, A.G. |
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履歴 | 登録 | 2020年10月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年10月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / em_3d_fitting_list / pdbx_initial_refinement_model Item: _em_3d_fitting_list.accession_code / _em_3d_fitting_list.initial_refinement_model_id ..._em_3d_fitting_list.accession_code / _em_3d_fitting_list.initial_refinement_model_id / _em_3d_fitting_list.source_name / _em_3d_fitting_list.type |
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