登録情報 | データベース: PDB / ID: 6z2s |
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タイトル | Crystal structure of adhibin analogue-bound myosin-2 |
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要素 | Myosin-2 heavy chain |
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キーワード | MOTOR PROTEIN / myosin / inhibitor / adhibin analogue / carbazole / pre-powerstroke state / hydrolase |
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機能・相同性 | 機能・相同性情報
calcium-dependent ATPase activity / pseudopodium retraction / uropod retraction / cytoplasmic actin-based contraction involved in forward cell motility / phagocytic cup base / pathogen-containing vacuole / response to differentiation-inducing factor 1 / equatorial cell cortex / contractile actin filament bundle assembly / cell trailing edge ...calcium-dependent ATPase activity / pseudopodium retraction / uropod retraction / cytoplasmic actin-based contraction involved in forward cell motility / phagocytic cup base / pathogen-containing vacuole / response to differentiation-inducing factor 1 / equatorial cell cortex / contractile actin filament bundle assembly / cell trailing edge / contractile vacuole organization / myosin filament assembly / aggregation involved in sorocarp development / culmination involved in sorocarp development / RHO GTPases activate PAKs / adenyl nucleotide binding / actomyosin contractile ring / hypotonic response / uropod / actin-myosin filament sliding / detection of mechanical stimulus / apical cortex / negative regulation of actin filament polymerization / bleb assembly / actomyosin / substrate-dependent cell migration, cell extension / myosin filament / filopodium assembly / early phagosome / myosin II complex / cortical actin cytoskeleton organization / microfilament motor activity / cortical actin cytoskeleton / pseudopodium / cytoskeletal motor activity / cleavage furrow / mitotic cytokinesis / response to mechanical stimulus / 14-3-3 protein binding / response to cAMP / extracellular matrix / cell motility / response to hydrogen peroxide / chemotaxis / actin filament binding / protein localization / regulation of cell shape / cell cortex / cytoplasmic vesicle / cytoskeleton / calmodulin binding / ATP binding / identical protein binding / cytosol類似検索 - 分子機能 Myosin tail / Myosin tail / Myosin N-terminal SH3-like domain / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. ...Myosin tail / Myosin tail / Myosin N-terminal SH3-like domain / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / IQ motif profile. / Kinesin motor domain superfamily / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ACETATE ION / ADP METAVANADATE / 3,6-dibromo-1-(hydroxymethyl)carbazole / Myosin-2 heavy chain類似検索 - 構成要素 |
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生物種 | ![](img/tx_eukaryote.gif) Dictyostelium discoideum (キイロタマホコリカビ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Ewert, W. / Knoelker, H.-J. / Tsiavaliaris, G. / Preller, M. |
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資金援助 | ドイツ, 1件 組織 | 認可番号 | 国 |
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German Research Foundation (DFG) | PR 1478/2-1 | ドイツ |
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引用 | ジャーナル: To Be Published タイトル: The synthetic carbazole adhibin acts as selective myosin class-IX inhibitor in lung cancer cells 著者: Bader, A. / Ewert, W. / Knoelker, H.-J. / Preller, M. / Tsiavaliaris, G. |
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履歴 | 登録 | 2020年5月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年6月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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