登録情報 | データベース: PDB / ID: 6tfb |
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タイトル | Carbamazepine binds Frizzled8 |
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要素 | Frizzled-8 |
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キーワード | ONCOPROTEIN / Wnt receptor Frizzled8 carbamazepine |
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機能・相同性 | 機能・相同性情報
Wnt-Frizzled-LRP5/6 complex / Regulation of FZD by ubiquitination / Asymmetric localization of PCP proteins / Wnt receptor activity / non-canonical Wnt signaling pathway / Wnt-protein binding / neuronal dense core vesicle / canonical Wnt signaling pathway / PDZ domain binding / G protein-coupled receptor activity ...Wnt-Frizzled-LRP5/6 complex / Regulation of FZD by ubiquitination / Asymmetric localization of PCP proteins / Wnt receptor activity / non-canonical Wnt signaling pathway / Wnt-protein binding / neuronal dense core vesicle / canonical Wnt signaling pathway / PDZ domain binding / G protein-coupled receptor activity / Wnt signaling pathway / cell-cell signaling / T cell differentiation in thymus / angiogenesis / positive regulation of protein phosphorylation / signaling receptor binding / ubiquitin protein ligase binding / Golgi apparatus / extracellular region / plasma membrane類似検索 - 分子機能 Frizzled 8, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. ...Frizzled 8, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2.類似検索 - ドメイン・相同性 benzo[b][1]benzazepine-11-carboxamide / Frizzled-8類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.68 Å |
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データ登録者 | Zhao, Y. / Jones, E.Y. |
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資金援助 | 英国, 2件 組織 | 認可番号 | 国 |
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Medical Research Council (United Kingdom) | MR/M000141/1 | 英国 | Cancer Research UK | C375/A17721 | 英国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8. 著者: Zhao, Y. / Ren, J. / Hillier, J. / Lu, W. / Jones, E.Y. |
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履歴 | 登録 | 2019年11月13日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年2月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年3月4日 | Group: Database references / カテゴリ: citation / citation_author / Item: _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2020年4月8日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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