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TitleAntiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8.
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 3252-3260, Year 2020
Publish dateNov 13, 2019 (structure data deposition date)
AuthorsZhao, Y. / Ren, J. / Hillier, J. / Lu, W. / Jones, E.Y.
External linksJ. Med. Chem. / PubMed:32049522
MethodsX-ray diffraction
Resolution1.68 - 2.343 Å
Structure data

PDB-6tfb:
Carbamazepine binds Frizzled8
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-6tfm:
Frizzled8 CRD
Method: X-RAY DIFFRACTION / Resolution: 2.343 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-N6W:
benzo[b][1]benzazepine-11-carboxamide / medication*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsONCOPROTEIN / Wnt receptor Frizzled8 carbamazepine / Wnt receptor Frizzled8 CRD

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