登録情報 | データベース: PDB / ID: 2c3i |
---|
タイトル | CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I |
---|
要素 | - PIMTIDE
- PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1
|
---|
キーワード | TRANSFERASE/PEPTIDE / TRANSFERASE-PEPTIDE COMPLEX / COMPLEX TRANSFERASE-PEPTIDE / PIM1 / KINASE / CANCER / LEUKEMIA / ATP-BINDING / NUCLEAR PROTEIN / NUCLEOTIDE-BINDING / PHOSPHORYLATION / PROTO- ONCOGENE / SERINE/THREONINE-PROTEIN KINASE / TRANSFERASE |
---|
機能・相同性 | 機能・相同性情報
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling ...positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling / Signaling by FLT3 fusion proteins / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / nucleolus / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-IYZ / Serine/threonine-protein kinase pim-1類似検索 - 構成要素 |
---|
生物種 | HOMO SAPIENS (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
---|
データ登録者 | Philippakopoulos, P. / Knapp, S. / Debreczeni, J. / Bullock, A. / von Delft, F. / Sundstrom, M. / Arrowsmith, C. / Edwards, A. / Guo, K. / Weigelt, J. |
---|
引用 | ジャーナル: Cancer Res. / 年: 2007 タイトル: Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity. 著者: Pogacic, V. / Bullock, A.N. / Fedorov, O. / Filippakopoulos, P. / Gasser, C. / Biondi, A. / Meyer-Monard, S. / Knapp, S. / Schwaller, J. |
---|
履歴 | 登録 | 2005年10月7日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2005年11月1日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
---|
改定 1.2 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
---|
改定 1.3 | 2023年12月13日 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
---|
|
---|