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Yorodumi- PDB-1c8m: REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH V... -
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Entry | Database: PDB / ID: 1c8m | |||||||||
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Title | REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH VP63843 (PLECONARIL), AN ANTI-PICORNAVIRAL DRUG CURRENTLY IN CLINICAL TRIALS | |||||||||
Components | (HUMAN RHINOVIRUS 16 COAT ...) x 4 | |||||||||
Keywords | VIRUS / RHINOVIRUS COAT PROTEIN / HUMAN RHINOVIRUS 16 / ANTIVIRAL COMPOUND / DRUG / WIN COMPOUND / Icosahedral virus | |||||||||
Function / homology | Function and homology information symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase ...symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / DNA replication / RNA helicase activity / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | |||||||||
Biological species | Human rhinovirus 16 | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å | |||||||||
Authors | Chakravarty, S. / Bator, C.M. / Pevear, D.C. / Diana, G.D. / Rossmann, M.G. | |||||||||
Citation | Journal: to be published Title: THE REFINED STRUCTURE OF A PICORNAVIRUS INHIBITOR CURRENTLY IN CLINICAL TRIALS, WHEN COMPLEXED WITH HUMAN RHINOVIRUS 16 Authors: CHAKRAVARTY, S. / BATOR, C.M. / PEVEAR, D.C. / DIANA, G.D. / ROSSMANN, M.G. #1: Journal: Proc.Natl.Acad.Sci.USA / Year: 1999 Title: ANALYSIS OF THREE STRUCTURALLY RELATED ANTIVIRAL COMPOUNDS IN COMPLEX WITH HUMAN RHINOVIRUS 16 Authors: Hadfield, A.T. / Minor, I. / Diana, G.D. / Rossmann, M.G. #2: Journal: Structure / Year: 1997 Title: The Refined Structure of Human Rhinovirus 16 at 2.15 A Resolution: Implications for the Viral Life Cycle Authors: Hadfield, A.T. / Lee, W.M. / Zhao, R. / Oliveira, M.A. / Minor, I. / Rueckert, R.R. / Rossmann, M.G. #3: Journal: Structure / Year: 1993 Title: The Structure of Human Rhinovirus 16 Authors: Oliveira, M.A. / Zhao, R. / Lee, W.M. / Kremer, M.J. / Minor, I. / Rueckert, R.R. / Diana, G.D. / Pevear, D.C. / Dutko, F.J. / McKinlay, M.A. / Rossmann, M.G. #4: Journal: Proc.Natl.Acad.Sci.USA / Year: 1993 Title: Structure of a Human Rhinovirus Complexed with its Receptor Molecule Authors: Olson, N.H. / Kolatkar, P.R. / Oliveira, M.A. / Cheng, R.H. / Greve, J.M. / McClelland, A. / Baker, T.S. / Rossmann, M.G. #5: Journal: J.Mol.Biol. / Year: 1993 Title: A Comparison of the Anti-Rhinoviral Drug Binding Pocket in HRV14 and HRV1A Authors: Kim, K.H. / Willingmann, P. / Gong, Z.X. / Kremer, M.J. / Chapman, M.S. / Minor, I. / Oliveira, M.A. / Rossmann, M.G. / Andries, K. / Diana, G.D. / Dutko, F.J. / McKinlay, M.A. / Pevear, D.C. #6: Journal: J.Mol.Biol. / Year: 1989 Title: Crystal Structure of Human Rhinovirus Serotype 1A (HRV1A) Authors: Kim, S.S. / Smith, T.J. / Chapman, M.S. / Rossmann, M.G. / Pevear, D.C. / Dutko, F.J. / Felock, P.J. / Diana, G.D. / McKinlay, M.A. #7: Journal: Science / Year: 1986 Title: The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating Authors: Smith, T.J. / Kremer, M.J. / Luo, M. / Vriend, G. / Arnold, E. / Kamer, G. / Rossmann, M.G. / McKinlay, M.A. / Diana, G.D. / Otto, M.J. #8: Journal: Nature / Year: 1985 Title: Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses Authors: Rossmann, M.G. / Arnold, E. / Erickson, J.W. / Frankenberger, E.A. / Griffith, J.P. / Hecht, H.J. / Johnson, J.E. / Kamer, G. / Luo, M. / Mosser, A.G. / Rueckert, R.R. / Sherry, B. / Vriend, G. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1c8m.cif.gz | 188.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1c8m.ent.gz | 145.8 KB | Display | PDB format |
PDBx/mmJSON format | 1c8m.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/c8/1c8m ftp://data.pdbj.org/pub/pdb/validation_reports/c8/1c8m | HTTPS FTP |
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-Related structure data
Related structure data | 1aymS S: Starting model for refinement |
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Similar structure data |
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-Assembly
Deposited unit |
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5 |
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Unit cell |
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Symmetry | Point symmetry: (Hermann–Mauguin notation: 532 / Schoenflies symbol: I (icosahedral)) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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