EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Architecture of Human Mitochondrial Respiratory Megacomplex IIIIIV.
ジャーナル・号・ページ	Cell, Vol. 170, Issue 6, Page 1247-1257.e12, Year 2017
掲載日	2017年9月7日
著者	Runyu Guo / Shuai Zong / Meng Wu / Jinke Gu / Maojun Yang /
PubMed 要旨	The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, ...The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions. To understand its architecture, we examined the human respiratory chain megacomplex-IIIIIV (MCIIIIIV) with 140 subunits and a subset of associated cofactors using cryo-electron microscopy. The MCIIIIIV forms a circular structure with the dimeric CIII located in the center, where it is surrounded by two copies each of CI and CIV. Two cytochrome c (Cyt.c) molecules are positioned to accept electrons on the surface of the c state CIII dimer. Analyses indicate that CII could insert into the gaps between CI and CIV to form a closed ring, which we termed the electron transport chain supercomplex. The structure not only reveals the precise assignment of individual subunits of human CI and CIII, but also enables future in-depth analysis of the electron transport chain as a whole.
リンク	Cell / PubMed:28844695
手法	EM (単粒子)
解像度	3.4 - 17.4 Å
構造データ	6771 5xtb EMDB-6771, PDB-5xtb: Cryo-EM structure of human respiratory complex I matrix arm 手法: EM (単粒子) / 解像度: 3.4 Å 6772 5xtc EMDB-6772, PDB-5xtc: Cryo-EM structure of human respiratory complex I transmembrane arm 手法: EM (単粒子) / 解像度: 3.7 Å 6773 5xtd EMDB-6773, PDB-5xtd: Cryo-EM structure of human respiratory complex I 手法: EM (単粒子) / 解像度: 3.7 Å 6774 5xte EMDB-6774, PDB-5xte: Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) 手法: EM (単粒子) / 解像度: 3.4 Å 6775 5xth EMDB-6775, PDB-5xth: Cryo-EM structure of human respiratory supercomplex I1III2IV1 手法: EM (単粒子) / 解像度: 3.9 Å 6776 5xti EMDB-6776, PDB-5xti: Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 手法: EM (単粒子) / 解像度: 17.4 Å
化合物	ChemComp-SF4: IRON/SULFUR CLUSTER / 鉄・硫黄クラスター ChemComp-FMN: FLAVIN MONONUCLEOTIDE / FMN / フラビンモノヌクレオチド ChemComp-8Q1: S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate ChemComp-NDP: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / NADPH / ニコチンアミドアデニンジヌクレオチドリン酸 ChemComp-FES: FE2/S2 (INORGANIC) CLUSTER / 鉄・硫黄クラスター ChemComp-PLX: (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL / リン脂質YM ChemComp-CDL: CARDIOLIPIN / リン脂質YM / Cardiolipin ChemComp-PEE: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, リン脂質YM / Discrete optimized protein energy ChemComp-HEC: HEME C / Heme C ChemComp-HEM: PROTOPORPHYRIN IX CONTAINING FE / Heme B ChemComp-CU: COPPER (II) ION / 銅 ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-HEA: HEME-A / Heme A ChemComp-ZN*: Unknown entry
由来	homo sapiens (ヒト) bos taurus (ウシ)
キーワード	OXIDOREDUCTASE/ELECTRON TRANSPORT / Respiratory (呼吸器) / OXIDOREDUCTASE-ELECTRON TRANSPORT complex / ELECTRON TRANSPORT (電子伝達系) / Homo sapiens (ヒト) / Oxidoreductase (酸化還元酵素) / Complex / Supercomplex