タイトル | Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. |
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ジャーナル・号・ページ | Structure, Vol. 25, Page 750-761.e5, Year 2017 |
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掲載日 | 2016年2月28日 (構造データの登録日) |
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著者 | Fong, D.H. / Burk, D.L. / Blanchet, J. / Yan, A.Y. / Berghuis, A.M. |
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リンク | Structure / PubMed:28416110 |
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手法 | X線回折 |
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解像度 | 1.2 - 2.1 Å |
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構造データ | PDB-5igh: Macrolide 2'-phosphotransferase type I 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-5igi: Macrolide 2'-phosphotransferase type I - complex with guanosine and azithromycin 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-5igj: Macrolide 2'-phosphotransferase type I - complex with guanosine and clarithromycin 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-5igp: Macrolide 2'-phosphotransferase type I - complex with GDP and erythromycin 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5igr: Macrolide 2'-phosphotransferase type I - complex with GDP and oleandomycin 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5igs: Macrolide 2'-phosphotransferase type I - complex with guanosine and oleandomycin 手法: X-RAY DIFFRACTION / 解像度: 1.38 Å PDB-5igt: Macrolide 2'-phosphotransferase type I - complex with guanosine and erythromycin 手法: X-RAY DIFFRACTION / 解像度: 1.39 Å PDB-5igu: Macrolide 2'-phosphotransferase type II 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5igv: Macrolide 2'-phosphotransferase type II - complex with GDP and azithromycin 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-5igw: Macrolide 2'-phosphotransferase type II - complex with GDP and clarithromycin 手法: X-RAY DIFFRACTION / 解像度: 2.096 Å PDB-5igy: Macrolide 2'-phosphotransferase type II - complex with GDP and erythromycin 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-5igz: Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5ih0: Macrolide 2'-phosphotransferase type II Y92M mutant - complex with GDP and erythromycin 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-5ih1: Macrolide 2'-phosphotransferase type II - complex with GDP and phosphorylated josamycin 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å PDB-5iwu: Macrolide 2'-phosphotransferase type II complexed with erythromycin 手法: X-RAY DIFFRACTION / 解像度: 1.3 Å |
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化合物 | ChemComp-ZIO: (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE / 抗生剤*YM
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由来 | - escherichia coli (大腸菌)
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キーワード | TRANSFERASE / macrolide phosphotransferase / kinase / TRANSFERASE/ANTIBIOTIC / TRANSFERASE-ANTIBIOTIC complex |
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