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全データ125,731件中、1から20件目までを表示しています
-Preclinical characterization of the potent and selective MALT1 inhibitor safimaltib in B cell lymphoma models
To Be Published,
Philippar, U. / Lu, T. / Fontan, L. / Xia, M. / Vloemans, N. / Bekkers, M. / Gaudiano, M. / Irrechukwu, O. / van den Biggelaar, D. / Perova, T. ...Philippar, U. / Lu, T. / Fontan, L. / Xia, M. / Vloemans, N. / Bekkers, M. / Gaudiano, M. / Irrechukwu, O. / van den Biggelaar, D. / Perova, T. / Guimerans-Lorenzo, I. / Wnuk-Lipinska, K. / Cornelissen, I. / Van Heerden, M. / Van Der Leede, B. / Amssoms, K. / Xu, R. / Grant, J. / Trella, E. / Abraham, Y. / Kimpe, K. / Medaer, B. / Greway, T. / Snoeys, J. / Jacobs, F. / Cummings, M.D. / Sun, W. / Thuring, J.W. / Wu, T. / Gaj, S. / Verbist, B. / Connolly, P.J. / Austin, N. / Balasubramanian, S. / Kinyamu-Akunda, J. / Packman, K. / Edwards, J.P. / Elsayed, Y. / Fourneau, N. / Morschhauser, F. / Gerecitano, J. / Bussolari, J. / Melnick, A. / Attar, R.
手法: X線回折
-Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature
To Be Published,
Stuckey, J.I. / Vivat, V. / Dickson, B.M. / Setser, J.W. / Li, Y. / Cremers, C.M. / Wilson, J.E. / Peterle, D. / Engen, J.R. / Wales, T.E. ...Stuckey, J.I. / Vivat, V. / Dickson, B.M. / Setser, J.W. / Li, Y. / Cremers, C.M. / Wilson, J.E. / Peterle, D. / Engen, J.R. / Wales, T.E. / Wilcken, R. / Rohan, E.B. / Chenail, G. / Audia, J.E. / Sims, R.J.
手法: X線回折
-Crystal Structure of the beta-Glucosidase BglA9 in Complex with the Inhibitor Conduritol B Epoxide
To Be Published,
Rahman, U.U. / Sagmeister, T. / Grininger, C. / Gruber, K. / Khan, S.
手法: X線回折
-Cryo-EM Structure of GTP Cyclohydrolase I from Candida albicans bound to 8-oxo GTP at 1.74 A
To Be Published,
Oluwarotimi EA / Guo Y / Vago F / Klose T / Borek D / Mesecar AD / Center for Structural Biology of Infectious Diseases (CSBID)
手法: EM (単粒子)
-Cryo-EM Structure of GTP Cyclohydrolase I from Candida albicans
To Be Published,
Oluwarotimi EA / Guo Y / Borek D / Mesecar AD / Center for Structural Biology of Infectious Diseases (CSBID)
手法: EM (単粒子)
-Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
To Be Published,
Schuster S / Hartl FA / Stehle J / Beier F / Al-Hasani H / Reinhart C / Weng T-H / Kraemer S / Hamde P / Herz T ...Schuster S / Hartl FA / Stehle J / Beier F / Al-Hasani H / Reinhart C / Weng T-H / Kraemer S / Hamde P / Herz T / Oesterlin S / Schmidt M / Gross T / Stehl L / Kilb N / Juenemann G / Heiss K / Sinclair A / Schoettgen J / Meyer P / Atay B / Zaghla BKQ / Link S / Goll J / Leoni B / Steinmann B / Selinger O / Welsch S / Roth G / Michel H / Klatt M / Birkenfeld J
手法: EM (単粒子)
-Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion.
Science, Vol. 393, Issue 6813, Page eaec6299, Year 2026
Caleb R Glassman / Kheewoong Baek / Gaopeng Hou / Qiru Zeng / Christopher Nardone / Kate B Juergens / Eric Fujimura / Colin N O'Leary / Mamie Z Li / Joao A Paulo ...Caleb R Glassman / Kheewoong Baek / Gaopeng Hou / Qiru Zeng / Christopher Nardone / Kate B Juergens / Eric Fujimura / Colin N O'Leary / Mamie Z Li / Joao A Paulo / Eric S Fischer / Siyuan Ding / J Wade Harper / Stephen J Elledge
手法: EM (単粒子)
-Protein Engineering-Enabled Cryo-EM Investigation of Small GTPases.
J Mol Biol, Vol. 438, Issue 17, Page 169860, Year 2026
Zhengshan Hu / Unnatiben Rajeshbhai Patel / Eliezra Glasser / Akiko Koide / Shohei Koide
手法: EM (単粒子)
-Structural adaptation associated with signaling preference at the human Growth Hormone-Releasing Hormone Receptor.
Protein Cell, Vol. 17, Issue 9, Page 883-888, Year 2026
Ming-Wei Wang / Kaini Hang / Yue Qiu / Xianyue Chen / Yanyan Chen / Shengtian Huang / Zhaotong Cong / Qingtong Zhou
手法: EM (単粒子)
-The structure of the native cardiac crossbridge in the rigor state.
Sci Adv, Vol. 12, Issue 35, Page eaeg1209, Year 2026
Cristina M Risi / Tyler Nguyen / Betty Belknap / Howard D White / Jose R Pinto / Prescott B Chase / Vitold E Galkin
手法: EM (単粒子)
-A biased allosteric modulator is a molecular glue for βAR dimerization.
Nature, Year 2026
Jiemin Shen / Teja Nikhil Peddada / Konstantin E Komolov / Francesco De Pascali / Alexander M Garces / Haoqing Wang / Muhammad Ehsan / Pil Seok Chae / Michael T Lerch / Jeffrey L Benovic ...Jiemin Shen / Teja Nikhil Peddada / Konstantin E Komolov / Francesco De Pascali / Alexander M Garces / Haoqing Wang / Muhammad Ehsan / Pil Seok Chae / Michael T Lerch / Jeffrey L Benovic / Jun Xu / Brian K Kobilka
手法: EM (単粒子)
-Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies.
J Gen Physiol, Vol. 158, Issue 5, Year 2026
Kate M Crowther / Thibault R H Jouen-Tachoire / Peter Proks / Peter Rory Hall / Emma L Veale / Janina Sörmann / Karin E J Rödström / Thomas Müller / Saskia B Wortmann / Nina Barisic ...Kate M Crowther / Thibault R H Jouen-Tachoire / Peter Proks / Peter Rory Hall / Emma L Veale / Janina Sörmann / Karin E J Rödström / Thomas Müller / Saskia B Wortmann / Nina Barisic / Natalie Hauser / Vincenzo Salpietro / RaeLynn Forsyth / Linford Williams / Nora Derrabi / Carlos A Bacino / Jill A Rosenfeld / Henry Houlden / Simon Newstead / Caroline F Wright / James Fasham / Alistair A Mathie / Reza Maroofian / Stephen J Tucker
手法: EM (単粒子)
-Structural Insights into Native, Mature Human Endogenous Retrovirus K (HERV-K) Capsids
To Be Published,
Lyu C / Peeples CA / Zhang Z / Shen Y / Hou Z / Harding EF / Hope J / Perilla JR / Katzourakis A / Zhang P
手法: EM (サブトモグラム平均) / EM (単粒子)
-The in stiu structure of the mature capsid of bacteriophage A1002
-Programmed mineralization of metal-oxides by de novo designed protein templates
To Be Published,
Saragovi, A. / Pyles, H. / Bera, A.K. / Baker, D.
手法: X線回折
-Histone modification crosstalk between host and pathogen
-In-cell structural analysis reveals a distinctive chloroplast ribosome in Chlamydomonas reinhardtii
To Be Published,
Hou Z / Shen Y / Zhang Z / Lu P / Katzourakis A / Zhang P
手法: EM (サブトモグラム平均)
-Predictive improvement of an RNA polymerase ribozyme from its substrate-free cryo-EM structure
To Be Published,
Szokoli D / Hingey J / Zhiheng Y / Wu V / Toor N / Spellmon N / Rudolfs B / Mencino A / Haack DB / Das R
手法: EM (単粒子)
-Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.
Proc Natl Acad Sci U S A, Vol. 123, Issue 35, Page e2609226123, Year 2026
Jianbin Chen / Jiuwei Lu / Zhixu Long / Sol Yoon / Megan Fukunaga / Jikui Song
手法: EM (単粒子)
-Serum IgA proteomics reveals clonal composition and neutralization of dimeric and monomeric IgA repertoires against human norovirus.
Proc Natl Acad Sci U S A, Vol. 123, Issue 34, Page e2603905123, Year 2026
Juyeon Park / Gyunghee Jo / Yaoska Reyes / Whitney Pickens / Dae Sung Kim / Alexandra Beaver / Verónica P Costantini / Chang Liu / Daeun Kim / Daechan Park ...Juyeon Park / Gyunghee Jo / Yaoska Reyes / Whitney Pickens / Dae Sung Kim / Alexandra Beaver / Verónica P Costantini / Chang Liu / Daeun Kim / Daechan Park / Victoria Longo / Paul D Brewer-Jensen / Michael L Mallory / Ed Satterwhite / Rocio Zapata-Bustos / Jeffrey Marchioni / Mark R Zweigart / Becca A Flitter / Jan Vinjé / Julianna Han / Ted M Ross / Jiwon Lee / Jason J Lavinder / Sean N Tucker / Zunlong Ke / Andrew B Ward / Lisa C Lindesmith / Ralph S Baric / George Georgiou
手法: EM (単粒子)
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