Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.
Journal, issue, pages	J. Med. Chem., Year 2026
Publish date	Jan 7, 2020 (structure data deposition date)
Authors	West, R.M. / Bizga Nicolescu, R.C. / Brear, P. / Wagstaff, J. / Blaszczyk, B.K. / Deingruber, T. / Sanders, M.G. / Perez-Areales, F.J. / Spring, D.R. / Hyvonen, M.
External links	J. Med. Chem. / PubMed:42130460
Methods	X-ray diffraction
Resolution	1.692 - 2.769 Å
Structure data	PDB-6tuh: PH domain of Bruton's tyrosine kinase bound to compound 1 Method: X-RAY DIFFRACTION / Resolution: 2.25 Å PDB-7i90: Crystal Structure of 7 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.993 Å PDB-7i91: Crystal Structure of 13 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.93 Å PDB-7i92: Crystal Structure of 9 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.633 Å PDB-7i93: Crystal Structure of 27 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.91 Å PDB-7i94: Crystal Structure of 33 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.828 Å PDB-7i95: Crystal Structure of 25 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.991 Å PDB-7i96: Crystal Structure of 4 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.52 Å PDB-7i97: Crystal Structure of 8 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.692 Å PDB-7i98: Crystal Structure of 10 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.07 Å PDB-7i99: Crystal Structure of 22 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.97 Å PDB-7i9a: Crystal Structure of 24 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.11 Å PDB-7i9b: Crystal Structure of 32 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.769 Å PDB-7i9c: Crystal Structure of 30 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.939 Å PDB-7i9d: Crystal Structure of 14 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-7i9e: Crystal Structure of 18 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.91 Å PDB-7i9f: Crystal Structure of 16 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.04 Å PDB-7i9g: Crystal Structure of 28 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.698 Å PDB-7i9h: Crystal Structure of 26 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.589 Å PDB-7i9i: Crystal Structure of 2 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.83 Å PDB-9rl9: Crystal Structure of 24 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.11 Å PDB-9rmo: Crystal Structure of 31 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-9rn5: Crystal Structure of 33 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.83 Å PDB-9t0t: Crystal Structure of the correct enantiomer bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.73 Å PDB-9t1v: Crystal Structure of 17 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 2.41 Å PDB-9t21: Crystal Structure of 29 bound to the ph domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.869 Å PDB-9t23: Crystal Structure of 5 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.845 Å PDB-9t3g: Crystal Structure of 12 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.946 Å PDB-9t3m: Crystal Structure of 11 bound to the PH domain of Btk Method: X-RAY DIFFRACTION / Resolution: 1.8 Å
Chemicals	ChemComp-NXT: 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid ChemComp-MG: Unknown entry ChemComp-ZN: Unknown entry ChemComp-HOH: WATER PDB-1b6f: BIRCH POLLEN ALLERGEN BET V 1 PDB-1b6s: STRUCTURE OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE PDB-1b6t: PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH 3'-DEPHOSPHO-COA FROM ESCHERICHIA COLI PDB-1b6u: CRYSTAL STRUCTURE OF THE HUMAN KILLER CELL INHIBITORY RECEPTOR (KIR2DL3) SPECIFIC FOR HLA-CW3 RELATED ALLELES PDB-1b6x: 3,N4-ETHENO-2'-DEOXYCYTIDINE OPPOSITE GUANINE IN AN 11-MER DUPLEX, SOLUTION STRUCTURE FROM NMR AND MOLECULAR DYNAMICS, 4 STRUCTURES PDB-1b6v: CRYSTAL STRUCTURE OF A HYBRID BETWEEN RIBONUCLEASE A AND BOVINE SEMINAL RIBONUCLEASE PDB Unreleased entry PDB-1b6o: Unknown entry PDB-1b6p: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 PDB-1b6q: ALANINE 31 PROLINE MUTANT OF ROP PROTEIN PDB-1b6w: CRYSTAL STRUCTURE OF THE SELENOMETHIONINE VARIANT OF HISTONE HMFB FROM METHANOTHERMUS FERVIDUS PDB-1b6r: N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE FROM E. COLI PDB-1b6k: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5 PDB-1b6l: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4 PDB-1b6m: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6 ChemComp-CL: Unknown entry PDB Unreleased entry PDB-1b6n: Unknown entry PDB-1b6g: HALOALKANE DEHALOGENASE AT PH 5.0 CONTAINING CHLORIDE PDB-1b6h: OLIGO-PEPTIDE BINDING PROTEIN COMPLEXED WITH LYSYL-NORVALYL-LYSINE PDB-1b6i: T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C) PDB-1b6j: HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1 PDB-1jia: STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION PDB-1jr3: Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III PDB-1js1: Crystal Structure of a new transcarbamylase from the anaerobic bacterium Bacteroides fragilis at 2.0 A resolution PDB-1js0: Crystal Structure of 3D Domain-swapped RNase A Minor Trimer PDB-1js4: ENDO/EXOCELLULASE:CELLOBIOSE FROM THERMOMONOSPORA PDB-1js7: Solution Structure of dAAUAA DNA Bulge PDB-1js6: Crystal Structure of DOPA decarboxylase PDB-1jta: Crystal Structure of Pectate Lyase A (C2 form) PDB-1jtb: LIPID TRANSFER PROTEIN COMPLEXED WITH PALMITOYL COENZYME A, NMR, 16 STRUCTURES
Source	homo sapiens (human)
Keywords	TRANSFERASE / BTK / Covalent fragments / surface entrophy reduction / crystal engineering / HYDROLASE / Fragment based drug discovery / ph domain