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TitleCryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii.
Journal, issue, pagesCell Res, Vol. 27, Issue 10, Page 1275-1288, Year 2017
Publish dateAug 15, 2017
AuthorsZhifei Li / Qiang Guo / Lvqin Zheng / Yongsheng Ji / Yi-Ting Xie / De-Hua Lai / Zhao-Rong Lun / Xun Suo / Ning Gao /
PubMed AbstractAs an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. High- ...As an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. High-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. With cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, Trichomonas vaginalis and Toxoplasma gondii, at resolution of 3.2-3.4 Å. Although the ribosomal proteins from both pathogens are typical members of eukaryotic families, with a co-evolution pattern between certain species-specific insertions/extensions and neighboring ribosomal RNA (rRNA) expansion segments, the sizes of their rRNAs are sharply different. Very interestingly, rRNAs of T. vaginalis are in size comparable to prokaryotic counterparts, with nearly all the eukaryote-specific rRNA expansion segments missing. These structures facilitate the dissection of evolution path for ribosomal proteins and RNAs, and may aid in design of novel translation inhibitors.
External linksCell Res / PubMed:28809395 / PubMed Central
MethodsEM (single particle)
Resolution3.17 - 3.35 Å
Structure data

6778

5xxb

EMDB-6778, PDB-5xxb:
Large subunit of Toxoplasma gondii ribosome
Method: EM (single particle) / Resolution: 3.17 Å

6780

5xxu

EMDB-6780, PDB-5xxu:
Small subunit of Toxoplasma gondii ribosome
Method: EM (single particle) / Resolution: 3.35 Å

6784

5xy3

EMDB-6784, PDB-5xy3:
Large subunit of Trichomonas vaginalis ribosome
Method: EM (single particle) / Resolution: 3.2 Å

6788

5xyi

EMDB-6788, PDB-5xyi:
Small subunit of Trichomonas vaginalis ribosome
Method: EM (single particle) / Resolution: 3.35 Å

Source
  • toxoplasma gondii (eukaryote)
  • trichomonas vaginalis (eukaryote)
KeywordsRIBOSOME / parasitic ribosome / rRNA / rproteins / Toxoplasma gondii ribosome / rprotein / Trichomonas vaginalis ribosome

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