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Showing 1 - 50 of 142 items for (author: sobolevsky & ai)

EMDB-47295:
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Philanthotoxin-74

EMDB-47296:
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Nephilatoxin-8

EMDB-47297:
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Spermine

EMDB-47298:
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Kukoamine-A

EMDB-45933:
Structure of human full-length ancestral TRPV6 channel in apo open state

EMDB-45934:
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state

EMDB-45935:
Structure of human full-length derived TRPV6 channel in apo open state

EMDB-45936:
Structure of human full-length derived TRPV6 channel in Calmodulin-bound state

EMDB-44123:
Cryo-EM density of GluK2 amino-terminal domain (GluK2-ATD) from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to ConA

EMDB-44126:
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers

EMDB-44127:
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer

EMDB-44124:
Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA

EMDB-44125:
Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two ConA dimers. Type I interface between GluK2 ligand-binding domain and ConA

EMDB-44128:
Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344

EMDB-44129:
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to two concanavalin A dimers. Composite map.

EMDB-44130:
Open state of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one concanavalin A dimer. Composite map.

EMDB-44131:
Kainate receptor GluK2 in complex with agonist glutamate with pseudo 4-fold symmetrical ligand-binding domain layer

EMDB-44132:
Kainate receptor GluK2 in complex with agonist glutamate with asymmetric ligand-binding domain layer

EMDB-42994:
Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs

EMDB-42995:
Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

EMDB-42996:
Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

EMDB-42997:
Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs

EMDB-42998:
Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs

EMDB-43751:
TRPM7 structure in complex with anticancer agent CCT128930 in closed state

EMDB-40741:
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

EMDB-40742:
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)

EMDB-40743:
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state)

EMDB-40744:
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state)

EMDB-40745:
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)

EMDB-40746:
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state)

EMDB-40747:
Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

EMDB-40748:
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

EMDB-40749:
Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

EMDB-40750:
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state)

EMDB-16052:
Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4

EMDB-40676:
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)

EMDB-40958:
Cryo-EM structure of full-length human TRPV4 in apo state

EMDB-40959:
Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA

EMDB-40960:
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD

EMDB-40961:
Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD

EMDB-40962:
Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047

EMDB-29343:
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein

EMDB-29344:
Cryo-EM structure of human TRPV6 in the open state

EMDB-40496:
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state

EMDB-40497:
Cryo-EM structure of TRPM7 in GDN detergent in apo state

EMDB-40498:
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in open state

EMDB-40499:
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state

EMDB-40500:
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in closed state

EMDB-40501:
Cryo-EM structure of TRPM7 in GDN detergent in complex with inhibitor VER155008 in closed state

EMDB-40502:
Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state

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Oct 5, 2021. Nobel Prize for mechanically activated and temperature-gated ion channels

Nobel Prize for mechanically activated and temperature-gated ion channels

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