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- EMDB-38635: Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline -

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Basic information

Entry
Database: EMDB / ID: EMD-38635
TitleCryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline
Map datarefined map without post process
Sample
  • Complex: 55S ribosome with tigecycline
    • RNA: x 2 types
    • Protein or peptide: x 50 types
  • Ligand: x 3 types
Keywordsribosome / Tigecycline / antibiotic / CCDC124
Function / homology
Function and homology information


mitochondrial translational termination / mitochondrial translational elongation / translation release factor activity, codon nonspecific / microprocessor complex / Mitochondrial translation elongation / Mitochondrial translation termination / Mitochondrial translation initiation / mitochondrial large ribosomal subunit / peptidyl-tRNA hydrolase / mitochondrial ribosome ...mitochondrial translational termination / mitochondrial translational elongation / translation release factor activity, codon nonspecific / microprocessor complex / Mitochondrial translation elongation / Mitochondrial translation termination / Mitochondrial translation initiation / mitochondrial large ribosomal subunit / peptidyl-tRNA hydrolase / mitochondrial ribosome / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / mitochondrial small ribosomal subunit / mitochondrial translation / aminoacyl-tRNA hydrolase activity / anatomical structure morphogenesis / RNA processing / Mitochondrial protein degradation / rescue of stalled ribosome / cellular response to leukemia inhibitory factor / fibrillar center / double-stranded RNA binding / small ribosomal subunit rRNA binding / large ribosomal subunit / cell junction / large ribosomal subunit rRNA binding / 5S rRNA binding / endonuclease activity / mitochondrial inner membrane / negative regulation of translation / nuclear body / rRNA binding / ribosome / structural constituent of ribosome / mitochondrial matrix / translation / ribonucleoprotein complex / protein domain specific binding / mRNA binding / nucleotide binding / synapse / nucleolus / apoptotic process / mitochondrion / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol
Similarity search - Function
: / : / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / Mitochondrial ribosomal protein L55 / Ribosomal protein L37, mitochondrial / Mitochondrial ribosomal protein L46 NUDIX / Mitochondrial ribosomal protein L37 ...: / : / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / Mitochondrial ribosomal protein L55 / Ribosomal protein L37, mitochondrial / Mitochondrial ribosomal protein L46 NUDIX / Mitochondrial ribosomal protein L37 / Ribosomal protein S30, mitochondrial / Ribosomal protein L53, mitochondrial / 39S ribosomal protein L53/MRP-L53 / 39S ribosomal protein L42, mitochondrial / Mitochondrial 28S ribosomal protein S32 / Ribosomal protein L28/L40, mitochondrial / Mitochondrial ribosomal protein L28 / Ribosomal protein 63, mitochondrial / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / Ribosomal protein L51, mitochondrial / Growth arrest and DNA-damage-inducible proteins-interacting protein 1 / Mitochondrial ribosomal subunit / Mitochondrial ribosome protein 63 / Ribosomal protein L37/S30 / Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily / : / : / Mitochondrial 28S ribosomal protein S30 (PDCD9) / 39S ribosomal protein L52, mitochondrial / Mitoribosomal protein mL52 / : / Ribosomal protein L35, mitochondrial / MRPL44, double-stranded RNA binding domain / MRPL44 dsRNA-binding domain / Large ribosomal subunit protein mL44, endonuclease domain / : / Large ribosomal subunit protein bL9m C-terminal domain / Tim44-like domain / Tim44-like domain / Tim44 / : / : / Ribosomal protein L49/IMG2 / Mitochondrial large subunit ribosomal protein (Img2) / Ribosomal protein L46, N-terminal / 39S mitochondrial ribosomal protein L46 / Ribosomal protein L50, mitochondria / Ribosomal protein L27/L41, mitochondrial / Mitochondrial ribosomal protein L27 / Ribosomal subunit 39S / 39S ribosomal protein L46, mitochondrial / : / 39S ribosomal protein L43/54S ribosomal protein L51 / Ribosomal protein L47, mitochondrial / MRP-L47 superfamily, mitochondrial / Mitochondrial 39-S ribosomal protein L47 (MRP-L47) / Phosphatidylethanolamine-binding protein / Phosphatidylethanolamine-binding protein / Phosphatidylethanolamine-binding protein, eukaryotic / PEBP-like superfamily / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS-like / TGS domain profile. / TGS / Peptide chain release factor class I / RF-1 domain / Ribonuclease III, endonuclease domain superfamily / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / : / Beta-grasp domain superfamily / Ribosomal protein/NADH dehydrogenase domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / NTF2-like domain superfamily / NUDIX hydrolase-like domain superfamily / Ribosomal protein L11, bacterial-type / Ribosomal protein L10-like domain superfamily / Ribosomal protein L10P / Ribosomal protein L10 / Ribosomal protein L11, N-terminal / Ribosomal protein L11, N-terminal domain / Ribosomal protein L11/L12 / Ribosomal protein L11, C-terminal / Ribosomal protein L11, C-terminal domain superfamily / Ribosomal protein L11/L12, N-terminal domain superfamily / Ribosomal protein L11/L12 / Ribosomal protein L11, RNA binding domain / Ribosomal protein L28/L24 superfamily / Ribosomal protein L9, N-terminal domain superfamily / Ribosomal protein L9 / Ribosomal protein L9, N-terminal / Ribosomal protein L9, N-terminal domain / Ribosomal protein L9/RNase H1, N-terminal / Ribosomal protein L36 / Ribosomal protein L36 superfamily / Ribosomal protein L36 / Ribosomal protein L35 / Ribosomal protein L35 superfamily / Ribosomal protein L35
Similarity search - Domain/homology
Large ribosomal subunit protein mL52 / Mitochondrial ribosomal protein L18, isoform CRA_b / Large ribosomal subunit protein uL22m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Large ribosomal subunit protein uL23m ...Large ribosomal subunit protein mL52 / Mitochondrial ribosomal protein L18, isoform CRA_b / Large ribosomal subunit protein uL22m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Large ribosomal subunit protein uL23m / Large ribosomal subunit protein mL51 / Large ribosomal subunit protein uL2m / Large ribosomal subunit protein mL54 / Large ribosomal subunit protein uL14m / Large ribosomal subunit protein bL21m / Large ribosomal subunit protein mL55 / Large ribosomal subunit protein uL10m / Large ribosomal subunit protein mL41 / Large ribosomal subunit protein mL50 / Large ribosomal subunit protein mL43 / Large ribosomal subunit protein mL64 / Large ribosomal subunit protein uL30m / Large ribosomal subunit protein uL24m / Large ribosomal subunit protein mL38 / Large ribosomal subunit protein mL53 / Large ribosomal subunit protein mL48 / Large ribosomal subunit protein bL34m / Large ribosomal subunit protein mL63 / Large ribosomal subunit protein mL45 / Large ribosomal subunit protein bL32m / Large ribosomal subunit protein bL20m / Large ribosomal subunit protein uL13m / Large ribosomal subunit protein bL9m / Large ribosomal subunit protein uL4m / Large ribosomal subunit protein mL37 / Large ribosomal subunit protein mL46 / Large ribosomal subunit protein mL44 / Large ribosomal subunit protein uL29m / Large ribosomal subunit protein mL65 / Large ribosomal subunit protein mL40 / Large ribosomal subunit protein bL17m / Large ribosomal subunit protein mL66 / Large ribosomal subunit protein uL16m / Large ribosomal subunit protein mL39 / Large ribosomal subunit protein bL35m / Large ribosomal subunit protein uL15m / Large ribosomal subunit protein bL36m / Large ribosomal subunit protein bL27m / Large ribosomal subunit protein uL11m / Large ribosomal subunit protein mL42
Similarity search - Component
Biological speciesHomo sapiens (human)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.1 Å
AuthorsLi X / Wang M / Cheng J
Funding support1 items
OrganizationGrant numberCountry
Not funded
CitationJournal: Nat Commun / Year: 2024
Title: Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Authors: Xiang Li / Mengjiao Wang / Timo Denk / Robert Buschauer / Yi Li / Roland Beckmann / Jingdong Cheng /
Abstract: Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site. However, ...Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site. However, even though it is also cytotoxic for human cells, the molecular mechanism of its inhibition remains unclear. Here, we present cryo-EM structures of tigecycline-bound human mitochondrial 55S, 39S, cytoplasmic 80S and yeast cytoplasmic 80S ribosomes. We find that at clinically relevant concentrations, tigecycline effectively targets human 55S mitoribosomes, potentially, by hindering A-site tRNA accommodation and by blocking the peptidyl transfer center. In contrast, tigecycline does not bind to human 80S ribosomes under physiological concentrations. However, at high tigecycline concentrations, in addition to blocking the A-site, both human and yeast 80S ribosomes bind tigecycline at another conserved binding site restricting the movement of the L1 stalk. In conclusion, the observed distinct binding properties of tigecycline may guide new pathways for drug design and therapy.
History
DepositionJan 10, 2024-
Header (metadata) releaseJul 10, 2024-
Map releaseJul 10, 2024-
UpdateJul 10, 2024-
Current statusJul 10, 2024Processing site: PDBj / Status: Released

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Structure visualization

Supplemental images

emd_38635.png

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Map

FileDownload / File: emd_38635.map.gz / Format: CCP4 / Size: 282.6 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Annotationrefined map without post process
Projections & slices

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AxesZ (Sec.)Y (Row.)X (Col.)
1.06 Å/pix.
x 420 pix.
= 446.88 Å		1.06 Å/pix.
x 420 pix.
= 446.88 Å		1.06 Å/pix.
x 420 pix.
= 446.88 Å

Surface

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Images are generated by Spider.

Voxel sizeX=Y=Z: 1.064 Å
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Histogram (log scale)
Contour LevelBy AUTHOR: 0.01
Minimum - Maximum-0.017541928 - 0.068178624
Average (Standard dev.)-0.000022752163 (±0.003253123)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions420420420
Spacing420420420
CellA=B=C: 446.88 Å
α=β=γ: 90.0 °

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Supplemental data

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Additional map: local resolution filtered map using Relion

Fileemd_38635_additional_1.map
Annotationlocal resolution filtered map using Relion
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Half map: #1

Fileemd_38635_half_map_1.map
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Half map: #2

Fileemd_38635_half_map_2.map
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Sample components

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Entire : 55S ribosome with tigecycline

EntireName: 55S ribosome with tigecycline
Components
  • Complex: 55S ribosome with tigecycline
    • RNA: 16s rRNA
    • RNA: Val tRNA
    • Protein or peptide: Large ribosomal subunit protein uL2m
    • Protein or peptide: Large ribosomal subunit protein uL3m
    • Protein or peptide: Large ribosomal subunit protein uL4m
    • Protein or peptide: Large ribosomal subunit protein bL9m
    • Protein or peptide: Large ribosomal subunit protein uL10m
    • Protein or peptide: Large ribosomal subunit protein uL11m
    • Protein or peptide: Large ribosomal subunit protein uL13m
    • Protein or peptide: Large ribosomal subunit protein uL14m
    • Protein or peptide: Large ribosomal subunit protein uL15m
    • Protein or peptide: Large ribosomal subunit protein uL16m
    • Protein or peptide: Large ribosomal subunit protein bL17m
    • Protein or peptide: Mitochondrial ribosomal protein L18, isoform CRA_b
    • Protein or peptide: Large ribosomal subunit protein bL19m
    • Protein or peptide: Large ribosomal subunit protein bL20m
    • Protein or peptide: Large ribosomal subunit protein bL21m
    • Protein or peptide: 39S ribosomal protein L22, mitochondrial
    • Protein or peptide: Large ribosomal subunit protein uL23m
    • Protein or peptide: Large ribosomal subunit protein uL24m
    • Protein or peptide: Large ribosomal subunit protein bL27m
    • Protein or peptide: Large ribosomal subunit protein bL28m
    • Protein or peptide: Large ribosomal subunit protein uL29m
    • Protein or peptide: Large ribosomal subunit protein uL30m
    • Protein or peptide: Large ribosomal subunit protein bL32m
    • Protein or peptide: Large ribosomal subunit protein bL33m
    • Protein or peptide: Large ribosomal subunit protein bL34m
    • Protein or peptide: Large ribosomal subunit protein bL35m
    • Protein or peptide: Large ribosomal subunit protein bL36m
    • Protein or peptide: Large ribosomal subunit protein mL37
    • Protein or peptide: Large ribosomal subunit protein mL38
    • Protein or peptide: Large ribosomal subunit protein mL39
    • Protein or peptide: Large ribosomal subunit protein mL40
    • Protein or peptide: Large ribosomal subunit protein mL41
    • Protein or peptide: Large ribosomal subunit protein mL42
    • Protein or peptide: Large ribosomal subunit protein mL43
    • Protein or peptide: Large ribosomal subunit protein mL44
    • Protein or peptide: Large ribosomal subunit protein mL45
    • Protein or peptide: Large ribosomal subunit protein mL46
    • Protein or peptide: Large ribosomal subunit protein mL48
    • Protein or peptide: Large ribosomal subunit protein mL49
    • Protein or peptide: Large ribosomal subunit protein mL50
    • Protein or peptide: Large ribosomal subunit protein mL51
    • Protein or peptide: 39S ribosomal protein L52, mitochondrial
    • Protein or peptide: Large ribosomal subunit protein mL53
    • Protein or peptide: Large ribosomal subunit protein mL54
    • Protein or peptide: Large ribosomal subunit protein mL55
    • Protein or peptide: Large ribosomal subunit protein mL63
    • Protein or peptide: Large ribosomal subunit protein mL62
    • Protein or peptide: Large ribosomal subunit protein mL64
    • Protein or peptide: Large ribosomal subunit protein mL66
    • Protein or peptide: Large ribosomal subunit protein mL65
  • Ligand: MAGNESIUM ION
  • Ligand: TIGECYCLINE
  • Ligand: ZINC ION

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Supramolecule #1: 55S ribosome with tigecycline

SupramoleculeName: 55S ribosome with tigecycline / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#52
Source (natural)Organism: Homo sapiens (human)

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Macromolecule #1: 16s rRNA

MacromoleculeName: 16s rRNA / type: rna / ID: 1 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 500.019594 KDa
SequenceString: GCUAAACCUA GCCCCAAACC CACUCCACCU UACUACCAGA CAACCUUAGC CAAACCAUUU ACCCAAAUAA AGUAUAGGCG AUAGAAAUU GAAACCUGGC GCAAUAGAUA UAGUACCGCA AGGGAAAGAU GAAAAAUUAU AACCAAGCAU AAUAUAGCAA G GACUAACC ...String:
GCUAAACCUA GCCCCAAACC CACUCCACCU UACUACCAGA CAACCUUAGC CAAACCAUUU ACCCAAAUAA AGUAUAGGCG AUAGAAAUU GAAACCUGGC GCAAUAGAUA UAGUACCGCA AGGGAAAGAU GAAAAAUUAU AACCAAGCAU AAUAUAGCAA G GACUAACC CCUAUACCUU CUGCAUAAUG AAUUAACUAG AAAUAACUUU GCAAGGAGAG CCAAAGCUAA GACCCCCGAA AC CAGACGA GCUACCUAAG AACAGCUAAA AGAGCACACC CGUCUAUGUA GCAAAAUAGU GGGAAGAUUU AUAGGUAGAG GCG ACAAAC CUACCGAGCC UGGUGAUAGC UGGUUGUCCA AGAUAGAAUC UUAGUUCAAC UUUAAAUUUG CCCACAGAAC CCUC UAAAU CCCCUUGUAA AUUUAACUGU UAGUCCAAAG AGGAACAGCU CUUUGGACAC UAGGAAAAAA CCUUGUAGAG AGAGU AAAA AAUUUAACAC CCAUAGUAGG CCUAAAAGCA GCCACCAAUU AAGAAAGCGU UCAAGCUCAA CACCCACUAC CUAAAA AAU CCCAAACAUA UAACUGAACU CCUCACACCC AAUUGGACCA AUCUAUCACC CUAUAGAAGA ACUAAUGUUA GUAUAAG UA ACAUGAAAAC AUUCUCCUCC GCAUAAGCCU GCGUCAGAUU AAAACACUGA ACUGACAAUU AACAGCCCAA UAUCUACA A UCAACCAACA AGUCAUUAUU ACCCUCACUG UCAACCCAAC ACAGGCAUGC UCAUAAGGAA AGGUUAAAAA AAGUAAAAG GAACUCGGCA AAUCUUACCC CGCCUGUUUA CCAAAAACAU CACCUCUAGC AUCACCAGUA UUAGAGGCAC CGCCUGCCCA GUGACACAU GUUUAACGGC CGCGGUACCC UAACCGUGCA AAGGUAGCAU AAUCACUUGU UCCUUAAAUA GGGACCUGUA U GAAUGGCU CCACGAGGGU UCAGCUGUCU CUUACUUUUA ACCAGUGAAA UUGACCUGCC CGUGAAGAGG CGGGCAUAAC AC AGCAAGA CGAGAAGACC CUAUGGAGCU UUAAUUUAUU AAUGCAAACA GUACCUAACA AACCCACAGG UCCUAAACUA CCA AACCUG CAUUAAAAAU UUCGGUUGGG GCGACCUCGG AGCAGAACCC AACCUCCGAG CAGUACAUGC UAAGACUUCA CCAG UCAAA GCGAACUACU AUACUCAAUU GAUCCAAUAA CUUGACCAAC GGAACAAGUU ACCCUAGGGA UAACAGCGCA AUCCU AUUC UAGAGUCCAU AUCAACAAUA GGGUUUACGA CCUCGAUGUU GGAUCAGGAC AUCCCGAUGG UGCAGCCGCU AUUAAA GGU UCGUUUGUUC AACGAUUAAA GUCCUACGUG AUCUGAGUUC AGACCGGAGU AAUCCAGGUC GGUUUCUAUC UACUUUC AA AUUCCUCCCU GUACGAAAGG ACAAGAGAAA UAAGGCCUAC UUCACAAAGC GCCUUCCCCC GUAAAUGAUA UCAUCUCA A CUUAGUAUUA UACCCACACC CACCCAAGAA CAGGGUUU

GENBANK: GENBANK: MK321331.1

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Macromolecule #2: Val tRNA

MacromoleculeName: Val tRNA / type: rna / ID: 2 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.022131 KDa
SequenceString:
CAGAGUGUAG CUUAACACAA AGCACCCAAC UUACACUUAG GAGAUUUCAA CUUAACUUGA CCGCUCUGA

GENBANK: GENBANK: MN849618.1

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Macromolecule #3: Large ribosomal subunit protein uL2m

MacromoleculeName: Large ribosomal subunit protein uL2m / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 33.355941 KDa
SequenceString: MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTG RIRVHGIGGG HKQRYRMIDF LRFRPEETKS GPFEEKVIQV RYDPCRSADI ALVAGGSRKR WIIATENMQA G DTILNSNH ...String:
MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTG RIRVHGIGGG HKQRYRMIDF LRFRPEETKS GPFEEKVIQV RYDPCRSADI ALVAGGSRKR WIIATENMQA G DTILNSNH IGRMAVAARE GDAHPLGALP VGTLINNVES EPGRGAQYIR AAGTCGVLLR KVNGTAIIQL PSKRQMQVLE TC VATVGRV SNVDHNKRVI GKAGRNRWLG KRPNSGRWHR KGGWAGRKIR PLPPMKSYVK LPSASAQS

UniProtKB: Large ribosomal subunit protein uL2m

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Macromolecule #4: Large ribosomal subunit protein uL3m

MacromoleculeName: Large ribosomal subunit protein uL3m / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 38.689562 KDa
SequenceString: MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT S ILEFYREL ...String:
MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT S ILEFYREL GLPPKQTVKI FNITDNAAIK PGTPLYAAHF RPGQYVDVTA KTIGKGFQGV MKRWGFKGQP ATHGQTKTHR RP GAVATGD IGRVWPGTKM PGKMGNIYRT EYGLKVWRIN TKHNIIYVNG SVPGHKNCLV KVKDSKLPAY KDLGKNLPFP TYF PDGDEE ELPEDLYDEN VCQPGAPSIT FA

UniProtKB: Large ribosomal subunit protein uL3m

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Macromolecule #5: Large ribosomal subunit protein uL4m

MacromoleculeName: Large ribosomal subunit protein uL4m / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 34.970195 KDa
SequenceString: MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFAT APRLDILHQV AMWQKNFKRI SYAKTKTRAE VRGGGRKPWP QKGTGRARHG SIRSPLWRGG GVAHGPRGPT S YYYMLPMK ...String:
MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFAT APRLDILHQV AMWQKNFKRI SYAKTKTRAE VRGGGRKPWP QKGTGRARHG SIRSPLWRGG GVAHGPRGPT S YYYMLPMK VRALGLKVAL TVKLAQDDLH IMDSLELPTG DPQYLTELAH YRRWGDSVLL VDLTHEEMPQ SIVEATSRLK TF NLIPAVG LNVHSMLKHQ TLVLTLPTVA FLEDKLLWQD SRYRPLYPFS LPYSDFPRPL PHATQGPAAT PYHC

UniProtKB: Large ribosomal subunit protein uL4m

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Macromolecule #6: Large ribosomal subunit protein bL9m

MacromoleculeName: Large ribosomal subunit protein bL9m / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 30.296355 KDa
SequenceString: MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHR PKENLELILT QSVENVGVRG DLVSVKKSLG RNRLLPQGLA VYASPENKKL FEEEKLLRQE GKLEKIQTKA G EATVKFLK ...String:
MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHR PKENLELILT QSVENVGVRG DLVSVKKSLG RNRLLPQGLA VYASPENKKL FEEEKLLRQE GKLEKIQTKA G EATVKFLK SCRLEVGMKN NVKWELNPEI VARHFFKNLG VVVAPHTLKL PEEPITRWGE YWCEVTVNGL DTVRVPMSVV NF EKPKTKR YKYWLAQQAA KAMAPTSPQI

UniProtKB: Large ribosomal subunit protein bL9m

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Macromolecule #7: Large ribosomal subunit protein uL10m

MacromoleculeName: Large ribosomal subunit protein uL10m / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 29.322529 KDa
SequenceString: MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAV FQDNRMIAVC QNVALSAEDK LLMRHQLRKH KILMKVFPNQ VLKPFLEDSK YQNLLPLFVG HNMLLVSEEP K VKEMVRIL ...String:
MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAV FQDNRMIAVC QNVALSAEDK LLMRHQLRKH KILMKVFPNQ VLKPFLEDSK YQNLLPLFVG HNMLLVSEEP K VKEMVRIL RTVPFLPLLG GCIDDTILSR QGFINYSKLP SLPLVQGELV GGLTCLTAQT HSLLQHQPLQ LTTLLDQYIR EQ REKDSVM SANGKPDPDT VPDS

UniProtKB: Large ribosomal subunit protein uL10m

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Macromolecule #8: Large ribosomal subunit protein uL11m

MacromoleculeName: Large ribosomal subunit protein uL11m / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.716227 KDa
SequenceString: MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL S SEELAAFQ ...String:
MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL S SEELAAFQ KERAIFLAAQ KEADLAAQEE AAKK

UniProtKB: Large ribosomal subunit protein uL11m

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Macromolecule #9: Large ribosomal subunit protein uL13m

MacromoleculeName: Large ribosomal subunit protein uL13m / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.722988 KDa
SequenceString:
MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL SDCGDHVVIM NTRHIAFSGN KWEQKVYSSH TGYPGGFRQ VTAAQLHLRD PVAIVKLAIY GMLPKNLHRR TMMERLHLFP DEYIPEDILK NLVEELPQPR KIPKRLDEYT Q EEIDAFPR LWTPPEDYRL

UniProtKB: Large ribosomal subunit protein uL13m

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Macromolecule #10: Large ribosomal subunit protein uL14m

MacromoleculeName: Large ribosomal subunit protein uL14m / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.973702 KDa
SequenceString:
MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGH CMPGPRMTPR FDSNNVVLIE DNGNPVGTRI KTPIPTSLRK REGEYSKVLA IAQNFV

UniProtKB: Large ribosomal subunit protein uL14m

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Macromolecule #11: Large ribosomal subunit protein uL15m

MacromoleculeName: Large ribosomal subunit protein uL15m / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 33.47382 KDa
SequenceString: MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSF RRQYKPLSLN RLQYLIDLGR VDPSQPIDLT QLVNGRGVTI QPLKRDYGVQ LVEEGADTFT AKVNIEVQLA S ELAIAAIE ...String:
MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSF RRQYKPLSLN RLQYLIDLGR VDPSQPIDLT QLVNGRGVTI QPLKRDYGVQ LVEEGADTFT AKVNIEVQLA S ELAIAAIE KNGGVVTTAF YDPRSLDIVC KPVPFFLRGQ PIPKRMLPPE ELVPYYTDAK NRGYLADPAK FPEARLELAR KY GYILPDI TKDELFKMLC TRKDPRQIFF GLAPGWVVNM ADKKILKPTD ENLLKYYTS

UniProtKB: Large ribosomal subunit protein uL15m

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Macromolecule #12: Large ribosomal subunit protein uL16m

MacromoleculeName: Large ribosomal subunit protein uL16m / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 28.496285 KDa
SequenceString: MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAI LALGGGYLHW GHFEMMRLTI NRSMDPKNMF AIWRVPAPFK PITRKSVGHR MGGGKGAIDH YVTPVKAGRL V VEMGGRCE ...String:
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAI LALGGGYLHW GHFEMMRLTI NRSMDPKNMF AIWRVPAPFK PITRKSVGHR MGGGKGAIDH YVTPVKAGRL V VEMGGRCE FEEVQGFLDQ VAHKLPFAAK AVSRGTLEKM RKDQEERERN NQNPWTFERI ATANMLGIRK VLSPYDLTHK GK YWGKFYM PKRV

UniProtKB: Large ribosomal subunit protein uL16m

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Macromolecule #13: Large ribosomal subunit protein bL17m

MacromoleculeName: Large ribosomal subunit protein bL17m / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.083266 KDa
SequenceString:
MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKL FQVLAPRYKD QTGGYTRMLQ IPNRSLDRAK MAVIEYKGNC LPPLPLPRRD SHLTLLNQLL QGLRQDLRQS Q EASNHSSH TAQTPGI

UniProtKB: Large ribosomal subunit protein bL17m

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Macromolecule #14: Mitochondrial ribosomal protein L18, isoform CRA_b

MacromoleculeName: Mitochondrial ribosomal protein L18, isoform CRA_b / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.465348 KDa
SequenceString:
MALRSQFWGF SVCRNPGCRF AALSTSSEPA AKPEVDPVEN EAVAPEFTNR NPRNLELLSV ARKERGWRTV FPSREFWHRL RVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR L QSAMTEGG VVLREPQRIY E

UniProtKB: Mitochondrial ribosomal protein L18, isoform CRA_b

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Macromolecule #15: Large ribosomal subunit protein bL19m

MacromoleculeName: Large ribosomal subunit protein bL19m / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 33.584996 KDa
SequenceString: MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDP LKFQIERKDM LERRKVLHIP EFYVGSILRV TTADPYASGK ISQFLGICIQ RSGRGLGATF ILRNVIEGQG V EICFELYN ...String:
MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDP LKFQIERKDM LERRKVLHIP EFYVGSILRV TTADPYASGK ISQFLGICIQ RSGRGLGATF ILRNVIEGQG V EICFELYN PRVQEIQVVK LEKRLDDSLL YLRDALPEYS TFDVNMKPVV QEPNQKVPVN ELKVKMKPKP WSKRWERPNF NI KGIRFDL CLTEQQMKEA QKWNQPWLEF DMMREYDTSK IEAAIWKEIE ASKRS

UniProtKB: Large ribosomal subunit protein bL19m

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Macromolecule #16: Large ribosomal subunit protein bL20m

MacromoleculeName: Large ribosomal subunit protein bL20m / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.479654 KDa
SequenceString:
MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGN LVKCQVELNR KVLADLAIYE PKTFKSLAAL ASRRRHEGFA AALGDGKEPE GIFSRVVQYH

UniProtKB: Large ribosomal subunit protein bL20m

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Macromolecule #17: Large ribosomal subunit protein bL21m

MacromoleculeName: Large ribosomal subunit protein bL21m / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.847682 KDa
SequenceString: MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVT GQYGRLFAVV HFASRQWKVT SEDLILIGNE LDLACGERIR LEKVLLVGAD NFTLLGKPLL GKDLVRVEAT V IEKTESWP ...String:
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVT GQYGRLFAVV HFASRQWKVT SEDLILIGNE LDLACGERIR LEKVLLVGAD NFTLLGKPLL GKDLVRVEAT V IEKTESWP RIIMRFRKRK NFKKKRIVTT PQTVLRINSI EIAPCLL

UniProtKB: Large ribosomal subunit protein bL21m

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Macromolecule #18: 39S ribosomal protein L22, mitochondrial

MacromoleculeName: 39S ribosomal protein L22, mitochondrial / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.369527 KDa
SequenceString: MAAAVLGQLG ALWIHNLRSR GKLALGLLSF HSVLPQSYIH TSASLDISRK WEKKNKIVYP PQLPGEPRRP AEIYHCRRQI KYSKDKMWY LAKLIRGMSI DQALAQLEFN DKKGAKIIKE VLLEAQDMAV RDHNVEFRSN LYIAESTSGR GQCLKRIRYH G RGRFGIME ...String:
MAAAVLGQLG ALWIHNLRSR GKLALGLLSF HSVLPQSYIH TSASLDISRK WEKKNKIVYP PQLPGEPRRP AEIYHCRRQI KYSKDKMWY LAKLIRGMSI DQALAQLEFN DKKGAKIIKE VLLEAQDMAV RDHNVEFRSN LYIAESTSGR GQCLKRIRYH G RGRFGIME KVYCHYFVKL VEGPPPPPEP PKTAVAHAKE YIQQLRSRTI VHTL

UniProtKB: Large ribosomal subunit protein uL22m

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Macromolecule #19: Large ribosomal subunit protein uL23m

MacromoleculeName: Large ribosomal subunit protein uL23m / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.807189 KDa
SequenceString:
MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKK PDYKVAYVQL AHGQTFTFPD LFPEKDESPE GSAADDLYSM LEEERQQRQS SDPRRGGVPS WFGL

UniProtKB: Large ribosomal subunit protein uL23m

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Macromolecule #20: Large ribosomal subunit protein uL24m

MacromoleculeName: Large ribosomal subunit protein uL24m / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.953875 KDa
SequenceString: MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVG GLNTHYRYIG KTMDYRGTMI PSEAPLLHRQ VKLVDPMDRK PTEIEWRFTE AGERVRVSTR SGRIIPKPEF P RADGIVPE ...String:
MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVG GLNTHYRYIG KTMDYRGTMI PSEAPLLHRQ VKLVDPMDRK PTEIEWRFTE AGERVRVSTR SGRIIPKPEF P RADGIVPE TWIDGPKDTS VEDALERTYV PCLKTLQEEV MEAMGIKETR KYKKVYWY

UniProtKB: Large ribosomal subunit protein uL24m

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Macromolecule #21: Large ribosomal subunit protein bL27m

MacromoleculeName: Large ribosomal subunit protein bL27m / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.102859 KDa
SequenceString:
MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCL YALEEGIVRY TKEVYVPHPR NTEAVDLITR LPKGAVLYKT FVHVVPAKPE GTFKLVAML

UniProtKB: Large ribosomal subunit protein bL27m

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Macromolecule #22: Large ribosomal subunit protein bL28m

MacromoleculeName: Large ribosomal subunit protein bL28m / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 30.202867 KDa
SequenceString: MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM D LKRGMLLR ...String:
MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM D LKRGMLLR LARQDPQLHP EDPERRAAIY DKYKEFAIPE EEAEWVGLTL EEAIEKQRLL EEKDPVPLFK IYVAELIQQL QQ QALSEPA VVQKRASGQ

UniProtKB: Large ribosomal subunit protein bL28m

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Macromolecule #23: Large ribosomal subunit protein uL29m

MacromoleculeName: Large ribosomal subunit protein uL29m / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 29.508535 KDa
SequenceString: MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQ LRNKSNEDLH KLWYVLLKER NMLLTLEQEA KRQRLPMPSP ERLDKVVDSM DALDKVVQER EDALRLLQTG Q ERARPGAW ...String:
MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQ LRNKSNEDLH KLWYVLLKER NMLLTLEQEA KRQRLPMPSP ERLDKVVDSM DALDKVVQER EDALRLLQTG Q ERARPGAW RRDIFGRIIW HKFKQWVIPW HLNKRYNRKR FFALPYVDHF LRLEREKRAR IKARKENLER KKAKILLKKF PH LAEAQKS SLV

UniProtKB: Large ribosomal subunit protein uL29m

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Macromolecule #24: Large ribosomal subunit protein uL30m

MacromoleculeName: Large ribosomal subunit protein uL30m / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 18.582812 KDa
SequenceString:
MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKML GLEKAHTPQV HKNIPSVNAK LKVVKHLIRI KPLKLPQGLP AEENMSNTCL KSTGELVVQW HLKPVEQKAH E S

UniProtKB: Large ribosomal subunit protein uL30m

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Macromolecule #25: Large ribosomal subunit protein bL32m

MacromoleculeName: Large ribosomal subunit protein bL32m / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.437799 KDa
SequenceString:
MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEV NRCRRRNPQK LIKVKNNIDV CPECGHLKQK HVLCAYCYEK VCKETAEIRR QIGKQEGGPF KAPTIETVVL Y TGETPSEQ DQGKRIIERD RKRPSWFTQN

UniProtKB: Large ribosomal subunit protein bL32m

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Macromolecule #26: Large ribosomal subunit protein bL33m

MacromoleculeName: Large ribosomal subunit protein bL33m / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 7.635204 KDa
SequenceString:
MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK KIRSL

UniProtKB: Large ribosomal subunit protein bL33m

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Macromolecule #27: Large ribosomal subunit protein bL34m

MacromoleculeName: Large ribosomal subunit protein bL34m / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 10.183913 KDa
SequenceString:
MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKS LSH

UniProtKB: Large ribosomal subunit protein bL34m

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Macromolecule #28: Large ribosomal subunit protein bL35m

MacromoleculeName: Large ribosomal subunit protein bL35m / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.558488 KDa
SequenceString:
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKL PVRSLTYFSA RKGKRKTVKA VIDRFLRLHC GLWVRRKAGY KKKLWKKTPA RKKRLREFVF CNKTQSKLLD K MTTSFWKR RNWYVDDPYQ KYHDRTNLKV

UniProtKB: Large ribosomal subunit protein bL35m

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Macromolecule #29: Large ribosomal subunit protein bL36m

MacromoleculeName: Large ribosomal subunit protein bL36m / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.809301 KDa
SequenceString:
MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWY VYCKTHPRHK QRQM

UniProtKB: Large ribosomal subunit protein bL36m

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Macromolecule #30: Large ribosomal subunit protein mL37

MacromoleculeName: Large ribosomal subunit protein mL37 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 48.183344 KDa
SequenceString: MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYR SPPLHEHPLY KDQACYIFHH RCRLLEGVKQ ALWLTKTKLI EGLPEKVLSL VDDPRNHIEN QDECVLNVIS H ARLWQTTE ...String:
MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYR SPPLHEHPLY KDQACYIFHH RCRLLEGVKQ ALWLTKTKLI EGLPEKVLSL VDDPRNHIEN QDECVLNVIS H ARLWQTTE EIPKRETYCP VIVDNLIQLC KSQILKHPSL ARRICVQNST FSATWNRESL LLQVRGSGGA RLSTKDPLPT IA SREEIEA TKNHVLETFY PISPIIDLHE CNIYDVKNDT GFQEGYPYPY PHTLYLLDKA NLRPHRLQPD QLRAKMILFA FGS ALAQAR LLYGNDAKVL EQPVVVQSVG TDGRVFHFLV FQLNTTDLDC NEGVKNLAWV DSDQLLYQHF WCLPVIKKRV VVEP VGPVG FKPETFRKFL ALYLHGAA

UniProtKB: Large ribosomal subunit protein mL37

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Macromolecule #31: Large ribosomal subunit protein mL38

MacromoleculeName: Large ribosomal subunit protein mL38 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 44.65943 KDa
SequenceString: MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKID IGLPPPKVSR TQQLLERKQA IQELRANVEE ERAARLRTAS VPLDAVRAEW ERTCGPYHKQ RLAEYYGLYR D LFHGATFV ...String:
MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKID IGLPPPKVSR TQQLLERKQA IQELRANVEE ERAARLRTAS VPLDAVRAEW ERTCGPYHKQ RLAEYYGLYR D LFHGATFV PRVPLHVAYA VGEDDLMPVY CGNEVTPTEA AQAPEVTYEA EEGSLWTLLL TSLDGHLLEP DAEYLHWLLT NI PGNRVAE GQVTCPYLPP FPARGSGIHR LAFLLFKQDQ PIDFSEDARP SPCYQLAQRT FRTFDFYKKH QETMTPAGLS FFQ CRWDDS VTYIFHQLLD MREPVFEFVR PPPYHPKQKR FPHRQPLRYL DRYRDSHEPT YGIY

UniProtKB: Large ribosomal subunit protein mL38

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Macromolecule #32: Large ribosomal subunit protein mL39

MacromoleculeName: Large ribosomal subunit protein mL39 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 38.764785 KDa
SequenceString: MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPY SCAMHLSEWY CRKSILALVD GQPWDMYKPL TKSCEIKFLT FKDCDPGEVN KAYWRSCAMM MGCVIERAFK D EYMVNLVR ...String:
MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPY SCAMHLSEWY CRKSILALVD GQPWDMYKPL TKSCEIKFLT FKDCDPGEVN KAYWRSCAMM MGCVIERAFK D EYMVNLVR APEVPVISGA FCYDVVLDSK LDEWMPTKEN LRSFTKDAHA LIYKDLPFET LEVEAKVALE IFQHSKYKVD FI EEKASQN PERIVKLHRI GDFIDVSEGP LIPRTSICFQ YEVSAVHNLQ PTQPSLIRRF QGVSLPVHLR AHFTIWDKLL ERS RKMVTE DQSKATEECT ST

UniProtKB: Large ribosomal subunit protein mL39

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Macromolecule #33: Large ribosomal subunit protein mL40

MacromoleculeName: Large ribosomal subunit protein mL40 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.534422 KDa
SequenceString: MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFI TPLKFLDKAR ERPQVELTFE ETERRALLLK KWSLYKQQER KMERDTIRAM LEAQQEALEE LQLESPKLHA E AIKRDPNL ...String:
MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFI TPLKFLDKAR ERPQVELTFE ETERRALLLK KWSLYKQQER KMERDTIRAM LEAQQEALEE LQLESPKLHA E AIKRDPNL FPFEKEGPHY TPPIPNYQPP EGRYNDITKV YTQVEFKR

UniProtKB: Large ribosomal subunit protein mL40

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Macromolecule #34: Large ribosomal subunit protein mL41

MacromoleculeName: Large ribosomal subunit protein mL41 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.404708 KDa
SequenceString:
MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAA QLFSEAVAPA IEKDFKDGTF DPDNLEKYGF EPTQEGKLFQ LYPRNFLR

UniProtKB: Large ribosomal subunit protein mL41

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Macromolecule #35: Large ribosomal subunit protein mL42

MacromoleculeName: Large ribosomal subunit protein mL42 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.691176 KDa
SequenceString:
MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHD QVLKTRLEEK VEHLEEGPMI EQLSKMFFTT KHRWYPHGRY HRCRKNLNPP KDR

UniProtKB: Large ribosomal subunit protein mL42

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Macromolecule #36: Large ribosomal subunit protein mL43

MacromoleculeName: Large ribosomal subunit protein mL43 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.457789 KDa
SequenceString: MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESI HCKSVEEIST LVQKLADQSG LDVIRIRKPF HTDNPSIQGQ WHPFTNKPTT FRGLRPREVQ DPAPAQDTGL R LSAVAPQI ...String:
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESI HCKSVEEIST LVQKLADQSG LDVIRIRKPF HTDNPSIQGQ WHPFTNKPTT FRGLRPREVQ DPAPAQDTGL R LSAVAPQI LLPGWPDPPD LPTVDPISSS LTSAPAPMLS AVSCLPIVPA LTTVCSA

UniProtKB: Large ribosomal subunit protein mL43

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Macromolecule #37: Large ribosomal subunit protein mL44

MacromoleculeName: Large ribosomal subunit protein mL44 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
EC number: Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 37.583312 KDa
SequenceString: MASGLVRLLQ QGHRCLLAPV APKLVPPVRG VKKGFRAAFR FQKELERQRL LRCPPPPVRR SEKPNWDYHA EIQAFGHRLQ ENFSLDLLK TAFVNSCYIK SEEAKRQQLG IEKEAVLLNL KSNQELSEQG TSFSQTCLTQ FLEDEYPDMP TEGIKNLVDF L TGEEVVCH ...String:
MASGLVRLLQ QGHRCLLAPV APKLVPPVRG VKKGFRAAFR FQKELERQRL LRCPPPPVRR SEKPNWDYHA EIQAFGHRLQ ENFSLDLLK TAFVNSCYIK SEEAKRQQLG IEKEAVLLNL KSNQELSEQG TSFSQTCLTQ FLEDEYPDMP TEGIKNLVDF L TGEEVVCH VARNLAVEQL TLSEEFPVPP AVLQQTFFAV IGALLQSSGP ERTALFIRDF LITQMTGKEL FEMWKIINPM GL LVEELKK RNVSAPESRL TRQSGGTTAL PLYFVGLYCD KKLIAEGPGE TVLVAEEEAA RVALRKLYGF TENRRPWNYS KPK ETLRAE KSITAS

UniProtKB: Large ribosomal subunit protein mL44

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Macromolecule #38: Large ribosomal subunit protein mL45

MacromoleculeName: Large ribosomal subunit protein mL45 / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 35.402918 KDa
SequenceString: MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYV PPEGDARISS LSKEGLIERT ERMKKTMASQ VSIRRIKDYD ANFKIKDFPE KAKDIFIEAH LCLNNSDHDR L HTLVTEHC ...String:
MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYV PPEGDARISS LSKEGLIERT ERMKKTMASQ VSIRRIKDYD ANFKIKDFPE KAKDIFIEAH LCLNNSDHDR L HTLVTEHC FPDMTWDIKY KTVRWSFVES LEPSHVVQVR CSSMMNQGNV YGQITVRMHT RQTLAIYDRF GRLMYGQEDV PK DVLEYVV FEKQLTNPYG SWRMHTKIVP PWAPPKQPIL KTVMIPGPQL KPEEEYEEAQ GEAQKPQLA

UniProtKB: Large ribosomal subunit protein mL45

+
Macromolecule #39: Large ribosomal subunit protein mL46

MacromoleculeName: Large ribosomal subunit protein mL46 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 31.748107 KDa
SequenceString: MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHEL RALDENQRLA KKKADLHDEE DEQDILLAQD LEDMWEQKFL QFKLGARITE ADEKNDRTSL NRKLDRNLVL L VREKFGDQ ...String:
MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHEL RALDENQRLA KKKADLHDEE DEQDILLAQD LEDMWEQKFL QFKLGARITE ADEKNDRTSL NRKLDRNLVL L VREKFGDQ DVWILPQAEW QPGETLRGTA ERTLATLSEN NMEAKFLGNA PCGHYTFKFP QAMRTESNLG AKVFFFKALL LT GDFSQAG NKGHHVWVTK DELGDYLKPK YLAQVRRFVS DL

UniProtKB: Large ribosomal subunit protein mL46

+
Macromolecule #40: Large ribosomal subunit protein mL48

MacromoleculeName: Large ribosomal subunit protein mL48 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.970814 KDa
SequenceString: MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYG VLNIHLTAYD MTLAESYAQY VHNLCNSLSI KVEESYAMPT KTIEVLQLQD QGSKMLLDSV LTTHERVVQI S GLSATFAE ...String:
MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYG VLNIHLTAYD MTLAESYAQY VHNLCNSLSI KVEESYAMPT KTIEVLQLQD QGSKMLLDSV LTTHERVVQI S GLSATFAE IFLEIIQSSL PEGVRLSVKE HTEEDFKGRF KARPELEELL AKLK

UniProtKB: Large ribosomal subunit protein mL48

+
Macromolecule #41: Large ribosomal subunit protein mL49

MacromoleculeName: Large ribosomal subunit protein mL49 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 19.225043 KDa
SequenceString:
MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRS RMHNIPVYKD ITHGNRQMTV IRKVEGDIWA LQKDVEDFLS PLLGKTPVTQ VNEVTGTLRI KGYFDQELKA W LLEKGF

UniProtKB: Large ribosomal subunit protein mL49

+
Macromolecule #42: Large ribosomal subunit protein mL50

MacromoleculeName: Large ribosomal subunit protein mL50 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 18.349943 KDa
SequenceString:
MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDI SLEDSRLKFN LLAHLADDLG HVVPNSRLHQ MCRVRDVLDF YNVPIQDRSK FDELSASNLP PNLKITWSY

UniProtKB: Large ribosomal subunit protein mL50

+
Macromolecule #43: Large ribosomal subunit protein mL51

MacromoleculeName: Large ribosomal subunit protein mL51 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.125917 KDa
SequenceString:
MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQ RCIRKRKMVG SRMFADDLHN LNKRIRYLYK HFNRHGKFR

UniProtKB: Large ribosomal subunit protein mL51

+
Macromolecule #44: 39S ribosomal protein L52, mitochondrial

MacromoleculeName: 39S ribosomal protein L52, mitochondrial / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.696684 KDa
SequenceString:
MAALVTVLFT GVRRLHCSAA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM KGQLRRKAER ETFARRVVLL SQEMDAGLQ AWQLRQQKLQ EEQRKQENAL KPKGASLKSP LPSQ

UniProtKB: Large ribosomal subunit protein mL52

+
Macromolecule #45: Large ribosomal subunit protein mL53

MacromoleculeName: Large ribosomal subunit protein mL53 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.125859 KDa
SequenceString:
MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTA FASHIRARDA AGSGDKPGAD TGR

UniProtKB: Large ribosomal subunit protein mL53

+
Macromolecule #46: Large ribosomal subunit protein mL54

MacromoleculeName: Large ribosomal subunit protein mL54 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.844178 KDa
SequenceString:
MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPD AEYPEWLFEM NLGPPKTLEE LDPESREYWR RLRKQNIWRH NRLSKNKRL

UniProtKB: Large ribosomal subunit protein mL54

+
Macromolecule #47: Large ribosomal subunit protein mL55

MacromoleculeName: Large ribosomal subunit protein mL55 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.160433 KDa
SequenceString:
MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEER RARLRKREAQ LQSRKEYEQE LSDDLHVERY RQFWTRTKK

UniProtKB: Large ribosomal subunit protein mL55

+
Macromolecule #48: Large ribosomal subunit protein mL63

MacromoleculeName: Large ribosomal subunit protein mL63 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.292333 KDa
SequenceString:
MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIA DQLDHLNVTK KWS

UniProtKB: Large ribosomal subunit protein mL63

+
Macromolecule #49: Large ribosomal subunit protein mL62

MacromoleculeName: Large ribosomal subunit protein mL62 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidyl-tRNA hydrolase
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.674203 KDa
SequenceString: MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT E ASQTPKEP ...String:
MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT E ASQTPKEP TKEDVKLHRI RIENMNRERL RQKRIHSAVK TSRRVDMD

UniProtKB: Large ribosomal subunit protein mL62

+
Macromolecule #50: Large ribosomal subunit protein mL64

MacromoleculeName: Large ribosomal subunit protein mL64 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.426895 KDa
SequenceString: MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEE REWYPSLATM QESLRVKQLA EEQKRREREQ HIAECMAKMP QMIVNWQQQQ RENWEKAQAD KERRARLQAE A QELLGYQV ...String:
MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEE REWYPSLATM QESLRVKQLA EEQKRREREQ HIAECMAKMP QMIVNWQQQQ RENWEKAQAD KERRARLQAE A QELLGYQV DPRSARFQEL LQDLEKKERK RLKEEKQKRK KEARAAALAA AVAQDPAASG APSS

UniProtKB: Large ribosomal subunit protein mL64

+
Macromolecule #51: Large ribosomal subunit protein mL66

MacromoleculeName: Large ribosomal subunit protein mL66 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.224078 KDa
SequenceString: MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES PNPPNPSGQC PICRWNLKHK YNYDDVLLL SQFIRPHGGM LPRKITGLCQ EEHRKIEECV KMAHRAGLLP NHRPRLPEGV VPKSKPQLNR YLTRWAPGSV K PIYKKGPR ...String:
MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES PNPPNPSGQC PICRWNLKHK YNYDDVLLL SQFIRPHGGM LPRKITGLCQ EEHRKIEECV KMAHRAGLLP NHRPRLPEGV VPKSKPQLNR YLTRWAPGSV K PIYKKGPR WNRVRMPVGS PLLRDNVCYS RTPWKLYH

UniProtKB: Large ribosomal subunit protein mL66

+
Macromolecule #52: Large ribosomal subunit protein mL65

MacromoleculeName: Large ribosomal subunit protein mL65 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 50.429578 KDa
SequenceString: MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFM KYMVYPQTFA LNADRWYQYF TKTVFLSGLP PPPAEPEPEP EPEPEPALDL AALRAVACDC LLQEHFYLRR R RRVHRYEE ...String:
MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFM KYMVYPQTFA LNADRWYQYF TKTVFLSGLP PPPAEPEPEP EPEPEPALDL AALRAVACDC LLQEHFYLRR R RRVHRYEE SEVISLPFLD QLVSTLVGLL SPHNPALAAA ALDYRCPVHF YWVRGEEIIP RGHRRGRIDD LRYQIDDKPN NQ IRISKQL AEFVPLDYSV PIEIPTIKCK PDKLPLFKRQ YENHIFVGSK TADPCCYGHT QFHLLPDKLR RERLLRQNCA DQI EVVFRA NAIASLFAWT GAQAMYQGFW SEADVTRPFV SQAVITDGKY FSFFCYQLNT LALTTQADQN NPRKNICWGT QSKP LYETI EDNDVKGFND DVLLQIVHFL LNRPKEEKSQ LLEN

UniProtKB: Large ribosomal subunit protein mL65

+
Macromolecule #53: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 53 / Number of copies: 95 / Formula: MG
Molecular weightTheoretical: 24.305 Da

+
Macromolecule #54: TIGECYCLINE

MacromoleculeName: TIGECYCLINE / type: ligand / ID: 54 / Number of copies: 1 / Formula: T1C
Molecular weightTheoretical: 587.665 Da
Chemical component information

ChemComp-T1C:
TIGECYCLINE / medication, antibiotic*YM

+
Macromolecule #55: ZINC ION

MacromoleculeName: ZINC ION / type: ligand / ID: 55 / Number of copies: 3 / Formula: ZN
Molecular weightTheoretical: 65.409 Da

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 7.4
GridModel: Quantifoil R1.2/1.3 / Material: COPPER / Mesh: 300 / Support film - Material: CARBON / Support film - topology: CONTINUOUS / Support film - Film thickness: 2
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: GATAN K3 (6k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 1.0 µm
Sample stageCooling holder cryogen: NITROGEN
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

+
Image processing

Startup modelType of model: OTHER / Details: Relion
Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.1 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION / Number images used: 52961
Initial angle assignmentType: OTHER / Software - Name: RELION / Details: Relion
Final angle assignmentType: OTHER / Software - Name: RELION / Details: Relion
FSC plot (resolution estimation)

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Atomic model buiding 1

Initial modelPDB ID:

7a5i


Chain - Source name: PDB / Chain - Initial model type: experimental model
RefinementProtocol: RIGID BODY FIT
Output model

PDB-8xt3:
Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline

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