EMDB-38634: Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline

Basic information

Entry

Database: EMDB / ID: EMD-38634

• Title: Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline
• Map data: refined map without post process

Sample

• Complex: 55S ribosome with tigecycline
  • RNA: x 3 types
  • Protein or peptide: x 80 types
• Ligand: x 4 types

• Keywords: ribosome / Tigecycline / antibiotic

Function / homology

Function:

mitochondrial ribosome binding / mitochondrial translational termination / mitochondrial translational elongation / mitochondrial ribosome assembly / translation release factor activity, codon nonspecific / microprocessor complex / Mitochondrial translation elongation / Mitochondrial translation termination / Mitochondrial translation initiation / positive regulation of mitochondrial translation / mitochondrial large ribosomal subunit / negative regulation of mitotic nuclear division / peptidyl-tRNA hydrolase / mitochondrial ribosome / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / mitochondrial small ribosomal subunit / mitochondrial translation / aminoacyl-tRNA hydrolase activity / positive regulation of proteolysis / ribosomal small subunit binding / anatomical structure morphogenesis / RNA processing / Mitochondrial protein degradation / rescue of stalled ribosome / cellular response to leukemia inhibitory factor / apoptotic signaling pathway / fibrillar center / double-stranded RNA binding / small ribosomal subunit rRNA binding / large ribosomal subunit / cell junction / regulation of translation / ribosomal small subunit assembly / large ribosomal subunit rRNA binding / 5S rRNA binding / small ribosomal subunit / nuclear membrane / endonuclease activity / cell population proliferation / tRNA binding / mitochondrial inner membrane / negative regulation of translation / nuclear body / rRNA binding / ribosome / structural constituent of ribosome / mitochondrial matrix / translation / ribonucleoprotein complex / protein domain specific binding / intracellular membrane-bounded organelle / mRNA binding / nucleotide binding / synapse / nucleolus / GTP binding / apoptotic process / mitochondrion / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm

Domain/homology:

Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 / 28S ribosomal protein S26 / Mitochondrial ribosome subunit S26 / Cysteine alpha-hairpin motif superfamily / 28S ribosomal protein S27, mitochondrial / MRPS27/PTCD2 / Mitochondrial 28S ribosomal protein S27 / Ribosomal protein S22, mitochondrial / Ribosomal protein S23, mitochondrial / Ribosomal protein S23/S25, mitochondrial / Mitochondrial 28S ribosomal protein S31 / : / Mitochondrial 28S ribosomal protein S22 / Mitochondrial ribosomal protein S23 / Mitochondrial 28S ribosomal protein S31 / Ribosomal protein S29, mitochondrial / Ribosomal protein S28, mitochondrial / Mitochondrial 28S ribosomal protein S34 / 28S ribosomal protein S10, mitochondrial / Mitochondrial ribosomal protein MRP-S35 / Mitochondrial 28S ribosomal protein S34 / 28S ribosomal protein S24, mitochondrial / Pentatricopeptide repeat domain-containing protein 3 / 28S ribosomal protein S17, mitochondrial / 28S ribosomal protein S18b, mitochondrial / : / Mitochondrial ribosome subunit S24 / Small ribosomal subunit protein uS5m, N-terminal / Small ribosomal subunit protein mS39, PPR / 28S ribosomal protein S25, mitochondrial / : / : / Pentatricopeptide repeat domain / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / Mitochondrial ribosomal protein L55 / Ribosomal protein S27/S33, mitochondrial / Ribosomal protein S24/S35, mitochondrial / Mitochondrial ribosomal subunit S27 / Ribosomal protein L37, mitochondrial / Mitochondrial ribosomal protein L46 NUDIX / Mitochondrial ribosomal protein L37 / Ribosomal protein S24/S35, mitochondrial, conserved domain / Ribosomal protein S30, mitochondrial / Mitochondrial ribosomal subunit protein / Ribosomal protein L53, mitochondrial / 39S ribosomal protein L53/MRP-L53 / 39S ribosomal protein L42, mitochondrial / Mitochondrial 28S ribosomal protein S32 / Ribosomal protein L28/L40, mitochondrial / Mitochondrial ribosomal protein L28 / Ribosomal protein 63, mitochondrial / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / Ribosomal protein L51, mitochondrial / Growth arrest and DNA-damage-inducible proteins-interacting protein 1 / Mitochondrial ribosomal subunit / Mitochondrial ribosome protein 63 / Ribosomal protein L37/S30 / Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily / : / : / Mitochondrial 28S ribosomal protein S30 (PDCD9) / 39S ribosomal protein L52, mitochondrial / Mitoribosomal protein mL52 / : / Ribosomal protein L35, mitochondrial / MRPL44, double-stranded RNA binding domain / MRPL44 dsRNA-binding domain / Large ribosomal subunit protein mL44, endonuclease domain / : / Large ribosomal subunit protein bL9m C-terminal domain / Tim44-like domain / Tim44-like domain / Tim44 / Pentatricopeptide (PPR) repeat profile. / Ribosomal protein S23/S29, mitochondrial / Mitochondrial ribosomal death-associated protein 3 / : / : / Pentatricopeptide repeat / Ribosomal protein L49/IMG2 / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial large subunit ribosomal protein (Img2) / Mitochondrial mRNA-processing protein COX24, C-terminal / Mitochondrial domain of unknown function (DUF1713) / Ribosomal protein L46, N-terminal / 39S mitochondrial ribosomal protein L46 / Ribosomal protein L50, mitochondria / Ribosomal protein L27/L41, mitochondrial / Mitochondrial ribosomal protein L27 / Ribosomal subunit 39S / 39S ribosomal protein L46, mitochondrial / : / 39S ribosomal protein L43/54S ribosomal protein L51 / Ribosomal protein L47, mitochondrial / MRP-L47 superfamily, mitochondrial / Mitochondrial 39-S ribosomal protein L47 (MRP-L47) / Phosphatidylethanolamine-binding protein

Component:

Large ribosomal subunit protein mL52 / Mitochondrial ribosomal protein L18, isoform CRA_b / Large ribosomal subunit protein uL22m / Small ribosomal subunit protein uS12m / Small ribosomal subunit protein uS14m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Small ribosomal subunit protein mS29 / Small ribosomal subunit protein mS22 / Small ribosomal subunit protein mS25 / Small ribosomal subunit protein uS10m / Small ribosomal subunit protein mS35 / Small ribosomal subunit protein uS5m / Small ribosomal subunit protein uS11m / Small ribosomal subunit protein uS15m / Small ribosomal subunit protein bS21m / Small ribosomal subunit protein mS34 / Small ribosomal subunit protein bS6m / Small ribosomal subunit protein uS9m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Large ribosomal subunit protein uL23m / Large ribosomal subunit protein mL51 / Large ribosomal subunit protein uL2m / Large ribosomal subunit protein mL54 / Large ribosomal subunit protein uL14m / Large ribosomal subunit protein bL21m / Large ribosomal subunit protein mL55 / Large ribosomal subunit protein uL10m / Large ribosomal subunit protein mL41 / Large ribosomal subunit protein mL50 / Large ribosomal subunit protein mL43 / Large ribosomal subunit protein mL64 / Large ribosomal subunit protein uL30m / Small ribosomal subunit protein mS27 / Small ribosomal subunit protein mS31 / Large ribosomal subunit protein uL24m / Small ribosomal subunit protein mS37 / Large ribosomal subunit protein mL38 / Small ribosomal subunit protein uS3m / Large ribosomal subunit protein mL53 / Small ribosomal subunit protein mS39 / Large ribosomal subunit protein mL48 / Large ribosomal subunit protein bL34m / Large ribosomal subunit protein mL63 / Large ribosomal subunit protein mL45 / Large ribosomal subunit protein bL32m / Large ribosomal subunit protein bL20m / Large ribosomal subunit protein uL13m / Large ribosomal subunit protein bL9m / Large ribosomal subunit protein uL4m / Small ribosomal subunit protein mS26 / Large ribosomal subunit protein mL37 / Large ribosomal subunit protein mL46 / Large ribosomal subunit protein mL44 / Large ribosomal subunit protein uL29m / Large ribosomal subunit protein mL65 / Large ribosomal subunit protein mL40 / Large ribosomal subunit protein bL17m / Large ribosomal subunit protein mL66 / Small ribosomal subunit protein mS38 / Large ribosomal subunit protein uL16m / Large ribosomal subunit protein mL39 / Large ribosomal subunit protein bL35m / Large ribosomal subunit protein uL15m / Large ribosomal subunit protein bL36m / Large ribosomal subunit protein bL27m / Small ribosomal subunit protein mS33 / Small ribosomal subunit protein bS1m / Small ribosomal subunit protein uS17m / Small ribosomal subunit protein uS7m / Small ribosomal subunit protein uS2m / Large ribosomal subunit protein uL11m / Small ribosomal subunit protein bS16m / Small ribosomal subunit protein bS18m / Small ribosomal subunit protein mS23 / Small ribosomal subunit protein mS40 / Large ribosomal subunit protein mL42

• Biological species: Homo sapiens (human)
• Method: single particle reconstruction / cryo EM / Resolution: 3.3 Å
• Authors: Li X / Wang M / Cheng J

Funding support

1 items

Organization	Grant number	Country
Not funded

• Citation: Journal: Nat Commun / Year: 2024; Title: Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.; Authors: Xiang Li / Mengjiao Wang / Timo Denk / Robert Buschauer / Yi Li / Roland Beckmann / Jingdong Cheng / ; Abstract: Tigecycline is widely used for treating complicated bacterial infections for which there are no effective drugs. It inhibits bacterial protein translation by blocking the ribosomal A-site. However, even though it is also cytotoxic for human cells, the molecular mechanism of its inhibition remains unclear. Here, we present cryo-EM structures of tigecycline-bound human mitochondrial 55S, 39S, cytoplasmic 80S and yeast cytoplasmic 80S ribosomes. We find that at clinically relevant concentrations, tigecycline effectively targets human 55S mitoribosomes, potentially, by hindering A-site tRNA accommodation and by blocking the peptidyl transfer center. In contrast, tigecycline does not bind to human 80S ribosomes under physiological concentrations. However, at high tigecycline concentrations, in addition to blocking the A-site, both human and yeast 80S ribosomes bind tigecycline at another conserved binding site restricting the movement of the L1 stalk. In conclusion, the observed distinct binding properties of tigecycline may guide new pathways for drug design and therapy.

History

Deposition	Jan 10, 2024	-
Header (metadata) release	Jul 10, 2024	-
Map release	Jul 10, 2024	-
Update	Nov 13, 2024	-
Current status	Nov 13, 2024	Processing site: PDBj / Status: Released

Map

• File: Download / File: emd_38634.map.gz / Format: CCP4 / Size: 282.6 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Annotation: refined map without post process
• Voxel size: X=Y=Z: 1.064 Å

Density

Contour Level	By AUTHOR: 0.01
Minimum - Maximum	-0.011757761 - 0.06503725
Average (Standard dev.)	0.00014350688 (±0.00391749)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 420 420 420 Spacing 420 420 420
Cell	A=B=C: 446.88 Å α=β=γ: 90.0 °

Supplemental data

Additional map: local resolution filtered map using Relion

• File: emd_38634_additional_1.map
• Annotation: local resolution filtered map using Relion

Additional map: composite map from multibody refinement and filtered by DeepEMhancer

• File: emd_38634_additional_2.map
• Annotation: composite map from multibody refinement and filtered by DeepEMhancer

Half map: #1

• File: emd_38634_half_map_1.map

Half map: #2

• File: emd_38634_half_map_2.map

Sample components

Entire : 55S ribosome with tigecycline

• Entire: Name: 55S ribosome with tigecycline

Components

• Complex: 55S ribosome with tigecycline
  • RNA: 16s rRNA
  • RNA: Val tRNA
  • Protein or peptide: Large ribosomal subunit protein uL2m
  • Protein or peptide: Large ribosomal subunit protein uL3m
  • Protein or peptide: Large ribosomal subunit protein uL4m
  • Protein or peptide: Large ribosomal subunit protein bL9m
  • Protein or peptide: Large ribosomal subunit protein uL10m
  • Protein or peptide: Large ribosomal subunit protein uL11m
  • Protein or peptide: Large ribosomal subunit protein uL13m
  • Protein or peptide: Large ribosomal subunit protein uL14m
  • Protein or peptide: Large ribosomal subunit protein uL15m
  • Protein or peptide: Large ribosomal subunit protein uL16m
  • Protein or peptide: Large ribosomal subunit protein bL17m
  • Protein or peptide: Mitochondrial ribosomal protein L18, isoform CRA_b
  • Protein or peptide: Large ribosomal subunit protein bL19m
  • Protein or peptide: Large ribosomal subunit protein bL20m
  • Protein or peptide: Large ribosomal subunit protein bL21m
  • Protein or peptide: 39S ribosomal protein L22, mitochondrial
  • Protein or peptide: Large ribosomal subunit protein uL23m
  • Protein or peptide: Large ribosomal subunit protein uL24m
  • Protein or peptide: Large ribosomal subunit protein bL27m
  • Protein or peptide: Large ribosomal subunit protein bL28m
  • Protein or peptide: Large ribosomal subunit protein uL29m
  • Protein or peptide: Large ribosomal subunit protein uL30m
  • Protein or peptide: Large ribosomal subunit protein bL32m
  • Protein or peptide: Large ribosomal subunit protein bL33m
  • Protein or peptide: Large ribosomal subunit protein bL34m
  • Protein or peptide: Large ribosomal subunit protein bL35m
  • Protein or peptide: Large ribosomal subunit protein bL36m
  • Protein or peptide: Large ribosomal subunit protein mL37
  • Protein or peptide: Large ribosomal subunit protein mL38
  • Protein or peptide: Large ribosomal subunit protein mL39
  • Protein or peptide: Large ribosomal subunit protein mL40
  • Protein or peptide: Large ribosomal subunit protein mL41
  • Protein or peptide: Large ribosomal subunit protein mL42
  • Protein or peptide: Large ribosomal subunit protein mL43
  • Protein or peptide: Large ribosomal subunit protein mL44
  • Protein or peptide: Large ribosomal subunit protein mL45
  • Protein or peptide: Large ribosomal subunit protein mL46
  • Protein or peptide: Large ribosomal subunit protein mL48
  • Protein or peptide: Large ribosomal subunit protein mL49
  • Protein or peptide: Large ribosomal subunit protein mL50
  • Protein or peptide: Large ribosomal subunit protein mL51
  • Protein or peptide: 39S ribosomal protein L52, mitochondrial
  • Protein or peptide: Large ribosomal subunit protein mL53
  • Protein or peptide: Large ribosomal subunit protein mL54
  • Protein or peptide: Large ribosomal subunit protein mL55
  • Protein or peptide: Large ribosomal subunit protein mL63
  • Protein or peptide: Large ribosomal subunit protein mL62
  • Protein or peptide: Large ribosomal subunit protein mL64
  • Protein or peptide: Large ribosomal subunit protein mL66
  • Protein or peptide: Large ribosomal subunit protein mL65
  • Protein or peptide: Small ribosomal subunit protein uS2m
  • Protein or peptide: Small ribosomal subunit protein uS3m
  • Protein or peptide: Small ribosomal subunit protein uS5m
  • Protein or peptide: Small ribosomal subunit protein bS6m
  • Protein or peptide: Small ribosomal subunit protein uS7m
  • Protein or peptide: Small ribosomal subunit protein uS9m
  • Protein or peptide: Small ribosomal subunit protein uS10m
  • Protein or peptide: Small ribosomal subunit protein uS11m
  • Protein or peptide: Small ribosomal subunit protein uS12m
  • Protein or peptide: Small ribosomal subunit protein uS14m
  • Protein or peptide: Small ribosomal subunit protein uS15m
  • Protein or peptide: Small ribosomal subunit protein bS16m
  • Protein or peptide: Small ribosomal subunit protein uS17m
  • Protein or peptide: Small ribosomal subunit protein mS40
  • Protein or peptide: Small ribosomal subunit protein bS18m
  • Protein or peptide: Small ribosomal subunit protein bS21m
  • Protein or peptide: Small ribosomal subunit protein mS22
  • Protein or peptide: Small ribosomal subunit protein mS23
  • Protein or peptide: Small ribosomal subunit protein mS25
  • Protein or peptide: Small ribosomal subunit protein mS26
  • Protein or peptide: Small ribosomal subunit protein mS27
  • Protein or peptide: Small ribosomal subunit protein bS1m
  • Protein or peptide: Small ribosomal subunit protein mS29
  • Protein or peptide: Small ribosomal subunit protein mS31
  • Protein or peptide: Small ribosomal subunit protein mS33
  • Protein or peptide: Small ribosomal subunit protein mS34
  • Protein or peptide: Small ribosomal subunit protein mS35
  • Protein or peptide: Small ribosomal subunit protein mS37
  • Protein or peptide: Small ribosomal subunit protein mS38
  • Protein or peptide: Small ribosomal subunit protein mS39
  • RNA: 12s rRNA
• Ligand: MAGNESIUM ION
• Ligand: TIGECYCLINE
• Ligand: ZINC ION
• Ligand: GUANOSINE-5'-DIPHOSPHATE

Supramolecule #1: 55S ribosome with tigecycline

• Supramolecule: Name: 55S ribosome with tigecycline / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#83
• Source (natural): Organism: Homo sapiens (human)

Macromolecule #1: 16s rRNA

• Macromolecule: Name: 16s rRNA / type: rna / ID: 1 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 500.019594 KDa

Sequence

String:

GCUAAACCUA GCCCCAAACC CACUCCACCU UACUACCAGA CAACCUUAGC CAAACCAUUU ACCCAAAUAA AGUAUAGGCG AUAGAAAUU GAAACCUGGC GCAAUAGAUA UAGUACCGCA AGGGAAAGAU GAAAAAUUAU AACCAAGCAU AAUAUAGCAA G GACUAACC CCUAUACCUU CUGCAUAAUG AAUUAACUAG AAAUAACUUU GCAAGGAGAG CCAAAGCUAA GACCCCCGAA AC CAGACGA GCUACCUAAG AACAGCUAAA AGAGCACACC CGUCUAUGUA GCAAAAUAGU GGGAAGAUUU AUAGGUAGAG GCG ACAAAC CUACCGAGCC UGGUGAUAGC UGGUUGUCCA AGAUAGAAUC UUAGUUCAAC UUUAAAUUUG CCCACAGAAC CCUC UAAAU CCCCUUGUAA AUUUAACUGU UAGUCCAAAG AGGAACAGCU CUUUGGACAC UAGGAAAAAA CCUUGUAGAG AGAGU AAAA AAUUUAACAC CCAUAGUAGG CCUAAAAGCA GCCACCAAUU AAGAAAGCGU UCAAGCUCAA CACCCACUAC CUAAAA AAU CCCAAACAUA UAACUGAACU CCUCACACCC AAUUGGACCA AUCUAUCACC CUAUAGAAGA ACUAAUGUUA GUAUAAG UA ACAUGAAAAC AUUCUCCUCC GCAUAAGCCU GCGUCAGAUU AAAACACUGA ACUGACAAUU AACAGCCCAA UAUCUACA A UCAACCAACA AGUCAUUAUU ACCCUCACUG UCAACCCAAC ACAGGCAUGC UCAUAAGGAA AGGUUAAAAA AAGUAAAAG GAACUCGGCA AAUCUUACCC CGCCUGUUUA CCAAAAACAU CACCUCUAGC AUCACCAGUA UUAGAGGCAC CGCCUGCCCA GUGACACAU GUUUAACGGC CGCGGUACCC UAACCGUGCA AAGGUAGCAU AAUCACUUGU UCCUUAAAUA GGGACCUGUA U GAAUGGCU CCACGAGGGU UCAGCUGUCU CUUACUUUUA ACCAGUGAAA UUGACCUGCC CGUGAAGAGG CGGGCAUAAC AC AGCAAGA CGAGAAGACC CUAUGGAGCU UUAAUUUAUU AAUGCAAACA GUACCUAACA AACCCACAGG UCCUAAACUA CCA AACCUG CAUUAAAAAU UUCGGUUGGG GCGACCUCGG AGCAGAACCC AACCUCCGAG CAGUACAUGC UAAGACUUCA CCAG UCAAA GCGAACUACU AUACUCAAUU GAUCCAAUAA CUUGACCAAC GGAACAAGUU ACCCUAGGGA UAACAGCGCA AUCCU AUUC UAGAGUCCAU AUCAACAAUA GGGUUUACGA CCUCGAUGUU GGAUCAGGAC AUCCCGAUGG UGCAGCCGCU AUUAAA GGU UCGUUUGUUC AACGAUUAAA GUCCUACGUG AUCUGAGUUC AGACCGGAGU AAUCCAGGUC GGUUUCUAUC UACUUUC AA AUUCCUCCCU GUACGAAAGG ACAAGAGAAA UAAGGCCUAC UUCACAAAGC GCCUUCCCCC GUAAAUGAUA UCAUCUCA A CUUAGUAUUA UACCCACACC CACCCAAGAA CAGGGUUU

GENBANK: GENBANK: MK321331.1

Macromolecule #2: Val tRNA

• Macromolecule: Name: Val tRNA / type: rna / ID: 2 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.022131 KDa

Sequence

String:

CAGAGUGUAG CUUAACACAA AGCACCCAAC UUACACUUAG GAGAUUUCAA CUUAACUUGA CCGCUCUGA

GENBANK: GENBANK: MN849618.1

Macromolecule #83: 12s rRNA

• Macromolecule: Name: 12s rRNA / type: rna / ID: 83 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 306.135156 KDa

Sequence

String:

AAUAGGUUUG GUCCUAGCCU UUCUAUUAGC UCUUAGUAAG AUUACACAUG CAAGCAUCCC CGUUCCAGUG AGUUCACCCU CUAAAUCAC CACGAUCAAA AGGAACAAGC AUCAAGCACG CAGCAAUGCA GCUCAAAACG CUUAGCCUAG CCACACCCCC A CGGGAAAC AGCAGUGAUU AACCUUUAGC AAUAAACGAA AGUUUAACUA AGCUAUACUA ACCCCAGGGU UGGUCAAUUU CG UGCCAGC CACCGCGGUC ACACGAUUAA CCCAAGUCAA UAGAAGCCGG CGUAAAGAGU GUUUUAGAUC ACCCCCUCCC CAA UAAAGC UAAAACUCAC CUGAGUUGUA AAAAACUCCA GUUGACACAA AAUAGACUAC GAAAGUGGCU UUAACAUAUC UGAA CACAC AAUAGCUAAG ACCCAAACUG GGAUUAGAUA CCCCACUAUG CUUAGCCCUA AACCUCAACA GUUAAAUCAA CAAAA CUGC UCGCCAGAAC ACUACGAGCC ACAGCUUAAA ACUCAAAGGA CCUGGCGGUG CUUCAUAUCC CUCUAGAGGA GCCUGU UCU GUAAUCGAUA AACCCCGAUC AACCUCACCA CCUCUUGCUC AGCCUAUAUA CCGCCAUCUU CAGCAAACCC UGAUGAA GG CUACAAAGUA AGCGCAAGUA CCCACGUAAA GACGUUAGGU CAAGGUGUAG CCCAUGAGGU GGCAAGAAAU GGGCUACA U UUUCUACCCC AGAAAACUAC GAUAGCCCUU AUGAAACUUA AGGGUCGAAG GUGGAUUUAG CAGUAAACUA AGAGUAGAG UGCUUAGUUG AACAGGGCCC UGAAGCGCGU ACACACCGCC CGUCACCCUC CUCAAGUAUA CUUCAAAGGA CAAUUAACUA AAACCCCUA CGCAUUUAUA UAGAGGAGAC AAGUCGUAAC AUGGUAAGUG UACUGGAAAG UGCACUUGGA CGAAC

GENBANK: GENBANK: KF962837.1

Macromolecule #3: Large ribosomal subunit protein uL2m

• Macromolecule: Name: Large ribosomal subunit protein uL2m / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.355941 KDa

Sequence

String:

MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTG RIRVHGIGGG HKQRYRMIDF LRFRPEETKS GPFEEKVIQV RYDPCRSADI ALVAGGSRKR WIIATENMQA G DTILNSNH IGRMAVAARE GDAHPLGALP VGTLINNVES EPGRGAQYIR AAGTCGVLLR KVNGTAIIQL PSKRQMQVLE TC VATVGRV SNVDHNKRVI GKAGRNRWLG KRPNSGRWHR KGGWAGRKIR PLPPMKSYVK LPSASAQS

UniProtKB: Large ribosomal subunit protein uL2m

Macromolecule #4: Large ribosomal subunit protein uL3m

• Macromolecule: Name: Large ribosomal subunit protein uL3m / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.689562 KDa

Sequence

String:

MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT S ILEFYREL GLPPKQTVKI FNITDNAAIK PGTPLYAAHF RPGQYVDVTA KTIGKGFQGV MKRWGFKGQP ATHGQTKTHR RP GAVATGD IGRVWPGTKM PGKMGNIYRT EYGLKVWRIN TKHNIIYVNG SVPGHKNCLV KVKDSKLPAY KDLGKNLPFP TYF PDGDEE ELPEDLYDEN VCQPGAPSIT FA

UniProtKB: Large ribosomal subunit protein uL3m

Macromolecule #5: Large ribosomal subunit protein uL4m

• Macromolecule: Name: Large ribosomal subunit protein uL4m / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 34.970195 KDa

Sequence

String:

MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFAT APRLDILHQV AMWQKNFKRI SYAKTKTRAE VRGGGRKPWP QKGTGRARHG SIRSPLWRGG GVAHGPRGPT S YYYMLPMK VRALGLKVAL TVKLAQDDLH IMDSLELPTG DPQYLTELAH YRRWGDSVLL VDLTHEEMPQ SIVEATSRLK TF NLIPAVG LNVHSMLKHQ TLVLTLPTVA FLEDKLLWQD SRYRPLYPFS LPYSDFPRPL PHATQGPAAT PYHC

UniProtKB: Large ribosomal subunit protein uL4m

Macromolecule #6: Large ribosomal subunit protein bL9m

• Macromolecule: Name: Large ribosomal subunit protein bL9m / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.296355 KDa

Sequence

String:

MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHR PKENLELILT QSVENVGVRG DLVSVKKSLG RNRLLPQGLA VYASPENKKL FEEEKLLRQE GKLEKIQTKA G EATVKFLK SCRLEVGMKN NVKWELNPEI VARHFFKNLG VVVAPHTLKL PEEPITRWGE YWCEVTVNGL DTVRVPMSVV NF EKPKTKR YKYWLAQQAA KAMAPTSPQI

UniProtKB: Large ribosomal subunit protein bL9m

Macromolecule #7: Large ribosomal subunit protein uL10m

• Macromolecule: Name: Large ribosomal subunit protein uL10m / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.322529 KDa

Sequence

String:

MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAV FQDNRMIAVC QNVALSAEDK LLMRHQLRKH KILMKVFPNQ VLKPFLEDSK YQNLLPLFVG HNMLLVSEEP K VKEMVRIL RTVPFLPLLG GCIDDTILSR QGFINYSKLP SLPLVQGELV GGLTCLTAQT HSLLQHQPLQ LTTLLDQYIR EQ REKDSVM SANGKPDPDT VPDS

UniProtKB: Large ribosomal subunit protein uL10m

Macromolecule #8: Large ribosomal subunit protein uL11m

• Macromolecule: Name: Large ribosomal subunit protein uL11m / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.716227 KDa

Sequence

String:

MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL S SEELAAFQ KERAIFLAAQ KEADLAAQEE AAKK

UniProtKB: Large ribosomal subunit protein uL11m

Macromolecule #9: Large ribosomal subunit protein uL13m

• Macromolecule: Name: Large ribosomal subunit protein uL13m / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.722988 KDa

Sequence

String:

MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL SDCGDHVVIM NTRHIAFSGN KWEQKVYSSH TGYPGGFRQ VTAAQLHLRD PVAIVKLAIY GMLPKNLHRR TMMERLHLFP DEYIPEDILK NLVEELPQPR KIPKRLDEYT Q EEIDAFPR LWTPPEDYRL

UniProtKB: Large ribosomal subunit protein uL13m

Macromolecule #10: Large ribosomal subunit protein uL14m

• Macromolecule: Name: Large ribosomal subunit protein uL14m / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.973702 KDa

Sequence

String:

MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGH CMPGPRMTPR FDSNNVVLIE DNGNPVGTRI KTPIPTSLRK REGEYSKVLA IAQNFV

UniProtKB: Large ribosomal subunit protein uL14m

Macromolecule #11: Large ribosomal subunit protein uL15m

• Macromolecule: Name: Large ribosomal subunit protein uL15m / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.47382 KDa

Sequence

String:

MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSF RRQYKPLSLN RLQYLIDLGR VDPSQPIDLT QLVNGRGVTI QPLKRDYGVQ LVEEGADTFT AKVNIEVQLA S ELAIAAIE KNGGVVTTAF YDPRSLDIVC KPVPFFLRGQ PIPKRMLPPE ELVPYYTDAK NRGYLADPAK FPEARLELAR KY GYILPDI TKDELFKMLC TRKDPRQIFF GLAPGWVVNM ADKKILKPTD ENLLKYYTS

UniProtKB: Large ribosomal subunit protein uL15m

Macromolecule #12: Large ribosomal subunit protein uL16m

• Macromolecule: Name: Large ribosomal subunit protein uL16m / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 28.496285 KDa

Sequence

String:

MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAI LALGGGYLHW GHFEMMRLTI NRSMDPKNMF AIWRVPAPFK PITRKSVGHR MGGGKGAIDH YVTPVKAGRL V VEMGGRCE FEEVQGFLDQ VAHKLPFAAK AVSRGTLEKM RKDQEERERN NQNPWTFERI ATANMLGIRK VLSPYDLTHK GK YWGKFYM PKRV

UniProtKB: Large ribosomal subunit protein uL16m

Macromolecule #13: Large ribosomal subunit protein bL17m

• Macromolecule: Name: Large ribosomal subunit protein bL17m / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.083266 KDa

Sequence

String:

MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKL FQVLAPRYKD QTGGYTRMLQ IPNRSLDRAK MAVIEYKGNC LPPLPLPRRD SHLTLLNQLL QGLRQDLRQS Q EASNHSSH TAQTPGI

UniProtKB: Large ribosomal subunit protein bL17m

Macromolecule #14: Mitochondrial ribosomal protein L18, isoform CRA_b

• Macromolecule: Name: Mitochondrial ribosomal protein L18, isoform CRA_b / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.465348 KDa

Sequence

String:

MALRSQFWGF SVCRNPGCRF AALSTSSEPA AKPEVDPVEN EAVAPEFTNR NPRNLELLSV ARKERGWRTV FPSREFWHRL RVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR L QSAMTEGG VVLREPQRIY E

UniProtKB: Mitochondrial ribosomal protein L18, isoform CRA_b

Macromolecule #15: Large ribosomal subunit protein bL19m

• Macromolecule: Name: Large ribosomal subunit protein bL19m / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.584996 KDa

Sequence

String:

MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDP LKFQIERKDM LERRKVLHIP EFYVGSILRV TTADPYASGK ISQFLGICIQ RSGRGLGATF ILRNVIEGQG V EICFELYN PRVQEIQVVK LEKRLDDSLL YLRDALPEYS TFDVNMKPVV QEPNQKVPVN ELKVKMKPKP WSKRWERPNF NI KGIRFDL CLTEQQMKEA QKWNQPWLEF DMMREYDTSK IEAAIWKEIE ASKRS

UniProtKB: Large ribosomal subunit protein bL19m

Macromolecule #16: Large ribosomal subunit protein bL20m

• Macromolecule: Name: Large ribosomal subunit protein bL20m / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.479654 KDa

Sequence

String:

MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGN LVKCQVELNR KVLADLAIYE PKTFKSLAAL ASRRRHEGFA AALGDGKEPE GIFSRVVQYH

UniProtKB: Large ribosomal subunit protein bL20m

Macromolecule #17: Large ribosomal subunit protein bL21m

• Macromolecule: Name: Large ribosomal subunit protein bL21m / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.847682 KDa

Sequence

String:

MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVT GQYGRLFAVV HFASRQWKVT SEDLILIGNE LDLACGERIR LEKVLLVGAD NFTLLGKPLL GKDLVRVEAT V IEKTESWP RIIMRFRKRK NFKKKRIVTT PQTVLRINSI EIAPCLL

UniProtKB: Large ribosomal subunit protein bL21m

Macromolecule #18: 39S ribosomal protein L22, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L22, mitochondrial / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.369527 KDa

Sequence

String:

MAAAVLGQLG ALWIHNLRSR GKLALGLLSF HSVLPQSYIH TSASLDISRK WEKKNKIVYP PQLPGEPRRP AEIYHCRRQI KYSKDKMWY LAKLIRGMSI DQALAQLEFN DKKGAKIIKE VLLEAQDMAV RDHNVEFRSN LYIAESTSGR GQCLKRIRYH G RGRFGIME KVYCHYFVKL VEGPPPPPEP PKTAVAHAKE YIQQLRSRTI VHTL

UniProtKB: Large ribosomal subunit protein uL22m

Macromolecule #19: Large ribosomal subunit protein uL23m

• Macromolecule: Name: Large ribosomal subunit protein uL23m / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.807189 KDa

Sequence

String:

MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKK PDYKVAYVQL AHGQTFTFPD LFPEKDESPE GSAADDLYSM LEEERQQRQS SDPRRGGVPS WFGL

UniProtKB: Large ribosomal subunit protein uL23m

Macromolecule #20: Large ribosomal subunit protein uL24m

• Macromolecule: Name: Large ribosomal subunit protein uL24m / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.953875 KDa

Sequence

String:

MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVG GLNTHYRYIG KTMDYRGTMI PSEAPLLHRQ VKLVDPMDRK PTEIEWRFTE AGERVRVSTR SGRIIPKPEF P RADGIVPE TWIDGPKDTS VEDALERTYV PCLKTLQEEV MEAMGIKETR KYKKVYWY

UniProtKB: Large ribosomal subunit protein uL24m

Macromolecule #21: Large ribosomal subunit protein bL27m

• Macromolecule: Name: Large ribosomal subunit protein bL27m / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.102859 KDa

Sequence

String:

MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCL YALEEGIVRY TKEVYVPHPR NTEAVDLITR LPKGAVLYKT FVHVVPAKPE GTFKLVAML

UniProtKB: Large ribosomal subunit protein bL27m

Macromolecule #22: Large ribosomal subunit protein bL28m

• Macromolecule: Name: Large ribosomal subunit protein bL28m / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.202867 KDa

Sequence

String:

MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM D LKRGMLLR LARQDPQLHP EDPERRAAIY DKYKEFAIPE EEAEWVGLTL EEAIEKQRLL EEKDPVPLFK IYVAELIQQL QQ QALSEPA VVQKRASGQ

UniProtKB: Large ribosomal subunit protein bL28m

Macromolecule #23: Large ribosomal subunit protein uL29m

• Macromolecule: Name: Large ribosomal subunit protein uL29m / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.508535 KDa

Sequence

String:

MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQ LRNKSNEDLH KLWYVLLKER NMLLTLEQEA KRQRLPMPSP ERLDKVVDSM DALDKVVQER EDALRLLQTG Q ERARPGAW RRDIFGRIIW HKFKQWVIPW HLNKRYNRKR FFALPYVDHF LRLEREKRAR IKARKENLER KKAKILLKKF PH LAEAQKS SLV

UniProtKB: Large ribosomal subunit protein uL29m

Macromolecule #24: Large ribosomal subunit protein uL30m

• Macromolecule: Name: Large ribosomal subunit protein uL30m / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.582812 KDa

Sequence

String:

MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKML GLEKAHTPQV HKNIPSVNAK LKVVKHLIRI KPLKLPQGLP AEENMSNTCL KSTGELVVQW HLKPVEQKAH E S

UniProtKB: Large ribosomal subunit protein uL30m

Macromolecule #25: Large ribosomal subunit protein bL32m

• Macromolecule: Name: Large ribosomal subunit protein bL32m / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.437799 KDa

Sequence

String:

MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEV NRCRRRNPQK LIKVKNNIDV CPECGHLKQK HVLCAYCYEK VCKETAEIRR QIGKQEGGPF KAPTIETVVL Y TGETPSEQ DQGKRIIERD RKRPSWFTQN

UniProtKB: Large ribosomal subunit protein bL32m

Macromolecule #26: Large ribosomal subunit protein bL33m

• Macromolecule: Name: Large ribosomal subunit protein bL33m / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 7.635204 KDa

Sequence

String:

MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK KIRSL

UniProtKB: Large ribosomal subunit protein bL33m

Macromolecule #27: Large ribosomal subunit protein bL34m

• Macromolecule: Name: Large ribosomal subunit protein bL34m / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.183913 KDa

Sequence

String:

MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKS LSH

UniProtKB: Large ribosomal subunit protein bL34m

Macromolecule #28: Large ribosomal subunit protein bL35m

• Macromolecule: Name: Large ribosomal subunit protein bL35m / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.558488 KDa

Sequence

String:

MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKL PVRSLTYFSA RKGKRKTVKA VIDRFLRLHC GLWVRRKAGY KKKLWKKTPA RKKRLREFVF CNKTQSKLLD K MTTSFWKR RNWYVDDPYQ KYHDRTNLKV

UniProtKB: Large ribosomal subunit protein bL35m

Macromolecule #29: Large ribosomal subunit protein bL36m

• Macromolecule: Name: Large ribosomal subunit protein bL36m / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 11.809301 KDa

Sequence

String:

MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWY VYCKTHPRHK QRQM

UniProtKB: Large ribosomal subunit protein bL36m

Macromolecule #30: Large ribosomal subunit protein mL37

• Macromolecule: Name: Large ribosomal subunit protein mL37 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.183344 KDa

Sequence

String:

MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYR SPPLHEHPLY KDQACYIFHH RCRLLEGVKQ ALWLTKTKLI EGLPEKVLSL VDDPRNHIEN QDECVLNVIS H ARLWQTTE EIPKRETYCP VIVDNLIQLC KSQILKHPSL ARRICVQNST FSATWNRESL LLQVRGSGGA RLSTKDPLPT IA SREEIEA TKNHVLETFY PISPIIDLHE CNIYDVKNDT GFQEGYPYPY PHTLYLLDKA NLRPHRLQPD QLRAKMILFA FGS ALAQAR LLYGNDAKVL EQPVVVQSVG TDGRVFHFLV FQLNTTDLDC NEGVKNLAWV DSDQLLYQHF WCLPVIKKRV VVEP VGPVG FKPETFRKFL ALYLHGAA

UniProtKB: Large ribosomal subunit protein mL37

Macromolecule #31: Large ribosomal subunit protein mL38

• Macromolecule: Name: Large ribosomal subunit protein mL38 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 44.65943 KDa

Sequence

String:

MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKID IGLPPPKVSR TQQLLERKQA IQELRANVEE ERAARLRTAS VPLDAVRAEW ERTCGPYHKQ RLAEYYGLYR D LFHGATFV PRVPLHVAYA VGEDDLMPVY CGNEVTPTEA AQAPEVTYEA EEGSLWTLLL TSLDGHLLEP DAEYLHWLLT NI PGNRVAE GQVTCPYLPP FPARGSGIHR LAFLLFKQDQ PIDFSEDARP SPCYQLAQRT FRTFDFYKKH QETMTPAGLS FFQ CRWDDS VTYIFHQLLD MREPVFEFVR PPPYHPKQKR FPHRQPLRYL DRYRDSHEPT YGIY

UniProtKB: Large ribosomal subunit protein mL38

Macromolecule #32: Large ribosomal subunit protein mL39

• Macromolecule: Name: Large ribosomal subunit protein mL39 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.764785 KDa

Sequence

String:

MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPY SCAMHLSEWY CRKSILALVD GQPWDMYKPL TKSCEIKFLT FKDCDPGEVN KAYWRSCAMM MGCVIERAFK D EYMVNLVR APEVPVISGA FCYDVVLDSK LDEWMPTKEN LRSFTKDAHA LIYKDLPFET LEVEAKVALE IFQHSKYKVD FI EEKASQN PERIVKLHRI GDFIDVSEGP LIPRTSICFQ YEVSAVHNLQ PTQPSLIRRF QGVSLPVHLR AHFTIWDKLL ERS RKMVTE DQSKATEECT ST

UniProtKB: Large ribosomal subunit protein mL39

Macromolecule #33: Large ribosomal subunit protein mL40

• Macromolecule: Name: Large ribosomal subunit protein mL40 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.534422 KDa

Sequence

String:

MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFI TPLKFLDKAR ERPQVELTFE ETERRALLLK KWSLYKQQER KMERDTIRAM LEAQQEALEE LQLESPKLHA E AIKRDPNL FPFEKEGPHY TPPIPNYQPP EGRYNDITKV YTQVEFKR

UniProtKB: Large ribosomal subunit protein mL40

Macromolecule #34: Large ribosomal subunit protein mL41

• Macromolecule: Name: Large ribosomal subunit protein mL41 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.404708 KDa

Sequence

String:

MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAA QLFSEAVAPA IEKDFKDGTF DPDNLEKYGF EPTQEGKLFQ LYPRNFLR

UniProtKB: Large ribosomal subunit protein mL41

Macromolecule #35: Large ribosomal subunit protein mL42

• Macromolecule: Name: Large ribosomal subunit protein mL42 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.691176 KDa

Sequence

String:

MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHD QVLKTRLEEK VEHLEEGPMI EQLSKMFFTT KHRWYPHGRY HRCRKNLNPP KDR

UniProtKB: Large ribosomal subunit protein mL42

Macromolecule #36: Large ribosomal subunit protein mL43

• Macromolecule: Name: Large ribosomal subunit protein mL43 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.457789 KDa

Sequence

String:

MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESI HCKSVEEIST LVQKLADQSG LDVIRIRKPF HTDNPSIQGQ WHPFTNKPTT FRGLRPREVQ DPAPAQDTGL R LSAVAPQI LLPGWPDPPD LPTVDPISSS LTSAPAPMLS AVSCLPIVPA LTTVCSA

UniProtKB: Large ribosomal subunit protein mL43

Macromolecule #37: Large ribosomal subunit protein mL44

• Macromolecule: Name: Large ribosomal subunit protein mL44 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO; EC number: Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 37.583312 KDa

Sequence

String:

MASGLVRLLQ QGHRCLLAPV APKLVPPVRG VKKGFRAAFR FQKELERQRL LRCPPPPVRR SEKPNWDYHA EIQAFGHRLQ ENFSLDLLK TAFVNSCYIK SEEAKRQQLG IEKEAVLLNL KSNQELSEQG TSFSQTCLTQ FLEDEYPDMP TEGIKNLVDF L TGEEVVCH VARNLAVEQL TLSEEFPVPP AVLQQTFFAV IGALLQSSGP ERTALFIRDF LITQMTGKEL FEMWKIINPM GL LVEELKK RNVSAPESRL TRQSGGTTAL PLYFVGLYCD KKLIAEGPGE TVLVAEEEAA RVALRKLYGF TENRRPWNYS KPK ETLRAE KSITAS

UniProtKB: Large ribosomal subunit protein mL44

Macromolecule #38: Large ribosomal subunit protein mL45

• Macromolecule: Name: Large ribosomal subunit protein mL45 / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 35.402918 KDa

Sequence

String:

MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYV PPEGDARISS LSKEGLIERT ERMKKTMASQ VSIRRIKDYD ANFKIKDFPE KAKDIFIEAH LCLNNSDHDR L HTLVTEHC FPDMTWDIKY KTVRWSFVES LEPSHVVQVR CSSMMNQGNV YGQITVRMHT RQTLAIYDRF GRLMYGQEDV PK DVLEYVV FEKQLTNPYG SWRMHTKIVP PWAPPKQPIL KTVMIPGPQL KPEEEYEEAQ GEAQKPQLA

UniProtKB: Large ribosomal subunit protein mL45

Macromolecule #39: Large ribosomal subunit protein mL46

• Macromolecule: Name: Large ribosomal subunit protein mL46 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 31.748107 KDa

Sequence

String:

MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHEL RALDENQRLA KKKADLHDEE DEQDILLAQD LEDMWEQKFL QFKLGARITE ADEKNDRTSL NRKLDRNLVL L VREKFGDQ DVWILPQAEW QPGETLRGTA ERTLATLSEN NMEAKFLGNA PCGHYTFKFP QAMRTESNLG AKVFFFKALL LT GDFSQAG NKGHHVWVTK DELGDYLKPK YLAQVRRFVS DL

UniProtKB: Large ribosomal subunit protein mL46

Macromolecule #40: Large ribosomal subunit protein mL48

• Macromolecule: Name: Large ribosomal subunit protein mL48 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.970814 KDa

Sequence

String:

MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYG VLNIHLTAYD MTLAESYAQY VHNLCNSLSI KVEESYAMPT KTIEVLQLQD QGSKMLLDSV LTTHERVVQI S GLSATFAE IFLEIIQSSL PEGVRLSVKE HTEEDFKGRF KARPELEELL AKLK

UniProtKB: Large ribosomal subunit protein mL48

Macromolecule #41: Large ribosomal subunit protein mL49

• Macromolecule: Name: Large ribosomal subunit protein mL49 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.225043 KDa

Sequence

String:

MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRS RMHNIPVYKD ITHGNRQMTV IRKVEGDIWA LQKDVEDFLS PLLGKTPVTQ VNEVTGTLRI KGYFDQELKA W LLEKGF

UniProtKB: Large ribosomal subunit protein mL49

Macromolecule #42: Large ribosomal subunit protein mL50

• Macromolecule: Name: Large ribosomal subunit protein mL50 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.349943 KDa

Sequence

String:

MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDI SLEDSRLKFN LLAHLADDLG HVVPNSRLHQ MCRVRDVLDF YNVPIQDRSK FDELSASNLP PNLKITWSY

UniProtKB: Large ribosomal subunit protein mL50

Macromolecule #43: Large ribosomal subunit protein mL51

• Macromolecule: Name: Large ribosomal subunit protein mL51 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.125917 KDa

Sequence

String:

MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQ RCIRKRKMVG SRMFADDLHN LNKRIRYLYK HFNRHGKFR

UniProtKB: Large ribosomal subunit protein mL51

Macromolecule #44: 39S ribosomal protein L52, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L52, mitochondrial / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.696684 KDa

Sequence

String:

MAALVTVLFT GVRRLHCSAA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM KGQLRRKAER ETFARRVVLL SQEMDAGLQ AWQLRQQKLQ EEQRKQENAL KPKGASLKSP LPSQ

UniProtKB: Large ribosomal subunit protein mL52

Macromolecule #45: Large ribosomal subunit protein mL53

• Macromolecule: Name: Large ribosomal subunit protein mL53 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.125859 KDa

Sequence

String:

MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTA FASHIRARDA AGSGDKPGAD TGR

UniProtKB: Large ribosomal subunit protein mL53

Macromolecule #46: Large ribosomal subunit protein mL54

• Macromolecule: Name: Large ribosomal subunit protein mL54 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.844178 KDa

Sequence

String:

MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPD AEYPEWLFEM NLGPPKTLEE LDPESREYWR RLRKQNIWRH NRLSKNKRL

UniProtKB: Large ribosomal subunit protein mL54

Macromolecule #47: Large ribosomal subunit protein mL55

• Macromolecule: Name: Large ribosomal subunit protein mL55 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.160433 KDa

Sequence

String:

MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEER RARLRKREAQ LQSRKEYEQE LSDDLHVERY RQFWTRTKK

UniProtKB: Large ribosomal subunit protein mL55

Macromolecule #48: Large ribosomal subunit protein mL63

• Macromolecule: Name: Large ribosomal subunit protein mL63 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.292333 KDa

Sequence

String:

MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIA DQLDHLNVTK KWS

UniProtKB: Large ribosomal subunit protein mL63

Macromolecule #49: Large ribosomal subunit protein mL62

• Macromolecule: Name: Large ribosomal subunit protein mL62 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidyl-tRNA hydrolase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.674203 KDa

Sequence

String:

MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT E ASQTPKEP TKEDVKLHRI RIENMNRERL RQKRIHSAVK TSRRVDMD

UniProtKB: Large ribosomal subunit protein mL62

Macromolecule #50: Large ribosomal subunit protein mL64

• Macromolecule: Name: Large ribosomal subunit protein mL64 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 25.426895 KDa

Sequence

String:

MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEE REWYPSLATM QESLRVKQLA EEQKRREREQ HIAECMAKMP QMIVNWQQQQ RENWEKAQAD KERRARLQAE A QELLGYQV DPRSARFQEL LQDLEKKERK RLKEEKQKRK KEARAAALAA AVAQDPAASG APSS

UniProtKB: Large ribosomal subunit protein mL64

Macromolecule #51: Large ribosomal subunit protein mL66

• Macromolecule: Name: Large ribosomal subunit protein mL66 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.224078 KDa

Sequence

String:

MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES PNPPNPSGQC PICRWNLKHK YNYDDVLLL SQFIRPHGGM LPRKITGLCQ EEHRKIEECV KMAHRAGLLP NHRPRLPEGV VPKSKPQLNR YLTRWAPGSV K PIYKKGPR WNRVRMPVGS PLLRDNVCYS RTPWKLYH

UniProtKB: Large ribosomal subunit protein mL66

Macromolecule #52: Large ribosomal subunit protein mL65

• Macromolecule: Name: Large ribosomal subunit protein mL65 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 50.429578 KDa

Sequence

String:

MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFM KYMVYPQTFA LNADRWYQYF TKTVFLSGLP PPPAEPEPEP EPEPEPALDL AALRAVACDC LLQEHFYLRR R RRVHRYEE SEVISLPFLD QLVSTLVGLL SPHNPALAAA ALDYRCPVHF YWVRGEEIIP RGHRRGRIDD LRYQIDDKPN NQ IRISKQL AEFVPLDYSV PIEIPTIKCK PDKLPLFKRQ YENHIFVGSK TADPCCYGHT QFHLLPDKLR RERLLRQNCA DQI EVVFRA NAIASLFAWT GAQAMYQGFW SEADVTRPFV SQAVITDGKY FSFFCYQLNT LALTTQADQN NPRKNICWGT QSKP LYETI EDNDVKGFND DVLLQIVHFL LNRPKEEKSQ LLEN

UniProtKB: Large ribosomal subunit protein mL65

Macromolecule #53: Small ribosomal subunit protein uS2m

• Macromolecule: Name: Small ribosomal subunit protein uS2m / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.298238 KDa

Sequence

String:

MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARV HLGHKAGCRH RFMEPYIFGS RLDHDIIDLE QTATHLQLAL NFTAHMAYRK GIILFISRNR QFSYLIENMA R DCGEYAHT RYFRGGMLTN ARLLFGPTVR LPDLIIFLHT LNNIFEPHVA VRDAAKMNIP TVGIVDTNCN PCLITYPVPG ND DSPLAVH LYCRLFQTAI TRAKEKRQQV EALYRLQGQK EPGDQGPAHP PGADMSHSL

UniProtKB: Small ribosomal subunit protein uS2m

Macromolecule #54: Small ribosomal subunit protein uS3m

• Macromolecule: Name: Small ribosomal subunit protein uS3m / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.046164 KDa

Sequence

String:

MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP VTYEEAHAPH YIAHRKGWLS LHTGNLDGED HAAERTVED VFLRKFMWGT FPGCLADQLV LKRRGNQLEI CAVVLRQLSP HKYYFLVGYS ETLLSYFYKC PVRLHLQTVP S KVVYKYL

UniProtKB: Small ribosomal subunit protein uS3m

Macromolecule #55: Small ribosomal subunit protein uS5m

• Macromolecule: Name: Small ribosomal subunit protein uS5m / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.094594 KDa

Sequence

String:

MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS SLGTRDTHPY ASLSRALQTQ CCISSPSHLM SQQYRPYSF FTKLTADELW KGALAETGAG AKKGRGKRTK KKKRKDLNRG QIIGEGRYGF LWPGLNVPLM KNGAVQTIAQ R SKEEQEKV EADMIQQREE WDRKKKMKVK RERGWSGNSW GGISLGPPDP GPCGETYEDF DTRILEVRNV FTMTAKEGRK KS IRVLVAV GNGKGAAGFS IGKATDRMDA FRKAKNRAVH HLHYIERYED HTIFHDISLR FKRTHIKMKK QPKGYGLRCH RAI ITICRL IGIKDMYAKV SGSINMLSLT QGLFRGLSRQ ETHQQLADKK GLHVVEIREE CGPLPIVVAS PRGPLRKDPE PEDE VPDVK LDWEDVKTAQ GMKRSVWSNL KRAAT

UniProtKB: Small ribosomal subunit protein uS5m

Macromolecule #56: Small ribosomal subunit protein bS6m

• Macromolecule: Name: Small ribosomal subunit protein bS6m / type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 14.250588 KDa

Sequence

String:

MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVI RGNIVKHPLT QELKECEGIV PVPLAEKLYS TKKRKK

UniProtKB: Small ribosomal subunit protein bS6m

Macromolecule #57: Small ribosomal subunit protein uS7m

• Macromolecule: Name: Small ribosomal subunit protein uS7m / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 28.186154 KDa

Sequence

String:

MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE EEKYVRELKK TQLIKAAPAG KTSSVFEDP VISKFTNMMM IGGNKVLARS LMIQTLEAVK RKQFEKYHAA SAEEQATIER NPYTIFHQAL KNCEPMIGLV P ILKGGRFY QVPVPLPDRR RRFLAMKWMI TECRDKKHQR TLMPEKLSHK LLEAFHNQGP VIKRKHDLHK MAEANRALAH YR WW

UniProtKB: Small ribosomal subunit protein uS7m

Macromolecule #58: Small ribosomal subunit protein uS9m

• Macromolecule: Name: Small ribosomal subunit protein uS9m / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.909859 KDa

Sequence

String:

MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR HTAFVIPKKN VPTSKRETYT EDFIKKQIEE FNIGKRHLA NMMGEDPETF TQEDIDRAIA YLFPSGLFEK RARPVMKHPE QIFPRQRAIQ WGEDGRPFHY LFYTGKQSYY S LMHDVYGM LLNLEKHQSH LQAKSLLPEK TVTRDVIGSR WLIKEELEEM LVEKLSDLDY MQFIRLLEKL LTSQCGAAEE EF VQRFRRS VTLESKKQLI EPVQYDEQGM AFSKSEGKRK TAKAEAIVYK HGSGRIKVNG IDYQLYFPIT QDREQLMFPF HFV DRLGKH DVTCTVSGGG RSAQAGAIRL AMAKALCSFV TEDEVEWMRQ AGLLTTDPRV RERKKPGQEG ARRKFTWKKR

UniProtKB: Small ribosomal subunit protein uS9m

Macromolecule #59: Small ribosomal subunit protein uS10m

• Macromolecule: Name: Small ribosomal subunit protein uS10m / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.0335 KDa

Sequence

String:

MAARTAFGAV CRRLWQGLGN FSVNTSKGNT AKNGGLLLST NMKWVQFSNL HVDVPKDLTK PVVTISDEPD ILYKRLSVLV KGHDKAVLD SYEYFAVLAA KELGISIKVH EPPRKIERFT LLQSVHIYKK HRVQYEMRTL YRCLELEHLT GSTADVYLEY I QRNLPEGV AMEVTKTQLE QLPEHIKEPI WETLSEEKEE SKS

UniProtKB: Small ribosomal subunit protein uS10m

Macromolecule #60: Small ribosomal subunit protein uS11m

• Macromolecule: Name: Small ribosomal subunit protein uS11m / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.648793 KDa

Sequence

String:

MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIK ASHNNTQIQV VSASNEPLAF ASCGTEGFRN AKKGTGIAAQ TAGIAAAARA KQKGVIHIRV VVKGLGPGRL S AMHGLIMG GLEVISITDN TPIPHNGCRP RKARKL

UniProtKB: Small ribosomal subunit protein uS11m

Macromolecule #61: Small ribosomal subunit protein uS12m

• Macromolecule: Name: Small ribosomal subunit protein uS12m / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.200947 KDa

Sequence

String:

MSWSGLLHGL NTSLTCGPAL VPRLWATCSM ATLNQMHRLG PPKRPPRKLG PTEGRPQLKG VVLCTFTRKP KKPNSANRKC CRVRLSTGR EAVCFIPGEG HTLQEHQIVL VEGGRTQDLP GVKLTVVRGK YDCGHVQKK

UniProtKB: Small ribosomal subunit protein uS12m

Macromolecule #62: Small ribosomal subunit protein uS14m

• Macromolecule: Name: Small ribosomal subunit protein uS14m / type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.168788 KDa

Sequence

String:

MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN TILPKILQDV ADEEIAALPR DSCPVRIRN RCVMTSRPRG VKRRWRLSRI VFRHLADHGQ LSGIQRATW

UniProtKB: Small ribosomal subunit protein uS14m

Macromolecule #63: Small ribosomal subunit protein uS15m

• Macromolecule: Name: Small ribosomal subunit protein uS15m / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.903293 KDa

Sequence

String:

MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA RGYVVRKPAQ SRLDDDPPPS TLLKDYQNVP GIEKVDDVV KRLLSLEMAN KKEMLKIKQE QFMKKIVANP EDTRSLEARI IALSVKIRSY EEHLEKHRKD KAHKRYLLMS I DQRKKMLK NLRNTNYDVF EKICWGLGIE YTFPPLYYRR AHRRFVTKKA LCIRVFQETQ KLKKRRRALK AAAAAQKQAK RR NPDSPAK AIPKTLKDSQ

UniProtKB: Small ribosomal subunit protein uS15m

Macromolecule #64: Small ribosomal subunit protein bS16m

• Macromolecule: Name: Small ribosomal subunit protein bS16m / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.371899 KDa

Sequence

String:

MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEK LLGLAGFFPL HPMMITNAER LRRKRAREVL LASQKTDAEA TDTEATET

UniProtKB: Small ribosomal subunit protein bS16m

Macromolecule #65: Small ribosomal subunit protein uS17m

• Macromolecule: Name: Small ribosomal subunit protein uS17m / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 14.526078 KDa

Sequence

String:

MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV GDIVLLRALP VPRAKHVKHE LAEIVFKVG KVIDPVTGKP CAGTTYLESP LSSETTQLSK NLEELNISSA Q

UniProtKB: Small ribosomal subunit protein uS17m

Macromolecule #66: Small ribosomal subunit protein mS40

• Macromolecule: Name: Small ribosomal subunit protein mS40 / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.440629 KDa

Sequence

String:

MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQR TRKTCIRRNK VVGNPCPICR DHKLHVDFRN VKLLEQFVCA HTGIIFYAPY TGVCVKQHKR LTQAIQKARD H GLLIYHIP QVEPRDLDFS TSHGAVSATP PAPTLVSGDP WYPWYNWKQP PERELSRLRR LYQGHLQEES GPPPESMPKM PP RTPAEAS STGQTGPQSA L

UniProtKB: Small ribosomal subunit protein mS40

Macromolecule #67: Small ribosomal subunit protein bS18m

• Macromolecule: Name: Small ribosomal subunit protein bS18m / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.876786 KDa

Sequence

String:

MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL PISMENPYKE PLKKCILCGK HVDYKNVQLL SQFVSPFTG CIYGRHITGL CGKKQKEITK AIKRAQIMGF MPVTYKDPAY LKDPKVCNIR YRE

UniProtKB: Small ribosomal subunit protein bS18m

Macromolecule #68: Small ribosomal subunit protein bS21m

• Macromolecule: Name: Small ribosomal subunit protein bS21m / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.764652 KDa

Sequence

String:

MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCR RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC

UniProtKB: Small ribosomal subunit protein bS21m

Macromolecule #69: Small ribosomal subunit protein mS22

• Macromolecule: Name: Small ribosomal subunit protein mS22 / type: protein_or_peptide / ID: 69 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 41.337316 KDa

Sequence

String:

MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAAES GSPETKKPTF MDEEVQSILT KMTGLNLQK TFKPAIQELK PPTYKLMTQA QLEEATRQAV EAAKVRLKMP PVLEERVPIN DVLAEDKILE GTETTKYVFT D ISYSIPHR ERFIVVREPS GTLRKASWEE RDRMIQVYFP KEGRKILTPI IFKEENLRTM YSQDRHVDVL NLCFAQFEPD ST EYIKVHH KTYEDIDKRG KYDLLRSTRY FGGMVWYFVN NKKIDGLLID QIQRDLIDDA TNLVQLYHVL HPDGQSAQGA KDQ AAEGIN LIKVFAKTEA QKGAYIELTL QTYQEALSRH SAAS

UniProtKB: Small ribosomal subunit protein mS22

Macromolecule #70: Small ribosomal subunit protein mS23

• Macromolecule: Name: Small ribosomal subunit protein mS23 / type: protein_or_peptide / ID: 70 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.805664 KDa

Sequence

String:

MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR VRYGKAKAPI QDIWYHEDRI RAKFYSVYGS GQRAFDLFN PNFKSTCQRF VEKYTELQKL GETDEEKLFV ETGKALLAEG VILRRVGEAR TQHGGSHVSR KSEHLSVRPQ T ALEENETQ KEVPQDQHLE APADQSKGLL PP

UniProtKB: Small ribosomal subunit protein mS23

Macromolecule #71: Small ribosomal subunit protein mS25

• Macromolecule: Name: Small ribosomal subunit protein mS25 / type: protein_or_peptide / ID: 71 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.146428 KDa

Sequence

String:

MPMKGRFPIR RTLQYLSQGN VVFKDSVKVM TVNYNTHGEL GEGARKFVFF NIPQIQYKNP WVQIMMFKNM TPSPFLRFYL DSGEQVLVD VETKSNKEIM EHIRKILGKN EETLREEEEE KKQLSHPANF GPRKYCLREC ICEVEGQVPC PSLVPLPKEM R GKYKAALK ADAQD

UniProtKB: Small ribosomal subunit protein mS25

Macromolecule #72: Small ribosomal subunit protein mS26

• Macromolecule: Name: Small ribosomal subunit protein mS26 / type: protein_or_peptide / ID: 72 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.25982 KDa

Sequence

String:

MLRALSRLGA GTPCRPRAPL VLPARGRKTR HDPLAKSKIE RVNMPPAVDP AEFFVLMERY QHYRQTVRAL RMEFVSEVQR KVHEARAGV LAERKALKDA AEHRELMAWN QAENRRLHEL RIARLRQEER EQEQRQALEQ ARKAEEVQAW AQRKEREVLQ L QEEVKNFI TRENLEARVE AALDSRKNYN WAITREGLVV RPQRRDS

UniProtKB: Small ribosomal subunit protein mS26

Macromolecule #73: Small ribosomal subunit protein mS27

• Macromolecule: Name: Small ribosomal subunit protein mS27 / type: protein_or_peptide / ID: 73 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 47.669262 KDa

Sequence

String:

MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL ADLASLMDKT FERKLPVSSL TISRLIDNIS SREEIDHAE YYLYKFRHSP NCWYLRNWTI HTWIRQCLKY DAQDKALYTL VNKVQYGIFP DNFTFNLLMD SFIKKENYKD A LSVVFEVM MQEAFEVPST QLLSLYVLFH CLAKKTDFSW EEERNFGASL LLPGLKQKNS VGFSSQLYGY ALLGKVELQQ GL RAVYHNM PLIWKPGYLD RALQVMEKVA ASPEDIKLCR EALDVLGAVL KALTSADGAS EEQSQNDEDN QGSEKLVEQL DIE ETEQSK LPQYLERFKA LHSKLQALGK IESEGLLSLT TQLVKEKLST CEAEDIATYE QNLQQWHLDL VQLIQREQQQ REQA KQEYQ AQKAAKASA

UniProtKB: Small ribosomal subunit protein mS27

Macromolecule #74: Small ribosomal subunit protein bS1m

• Macromolecule: Name: Small ribosomal subunit protein bS1m / type: protein_or_peptide / ID: 74 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.878846 KDa

Sequence

String:

MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPL TQMGPAKDKL VIGRIFHIVE NDLYIDFGGK FHCVCRRPEV DGEKYQKGTR VRLRLLDLEL TSRFLGATTD T TVLEANAV LLGIQESKDS RSKEEHHEK

UniProtKB: Small ribosomal subunit protein bS1m

Macromolecule #75: Small ribosomal subunit protein mS29

• Macromolecule: Name: Small ribosomal subunit protein mS29 / type: protein_or_peptide / ID: 75 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.634406 KDa

Sequence

String:

MMLKGITRLI SRIHKLDPGR FLHMGTQARQ SIAAHLDNQV PVESPRAISR TNENDPAKHG DQHEGQHYNI SPQDLETVFP HGLPPRFVM QVKTFSEACL MVRKPALELL HYLKNTSFAY PAIRYLLYGE KGTGKTLSLC HVIHFCAKQD WLILHIPDAH L WVKNCRDL LQSSYNKQRF DQPLEASTWL KNFKTTNERF LNQIKVQEKY VWNKRESTEK GSPLGEVVEQ GITRVRNATD AV GIVLKEL KRQSSLGMFH LLVAVDGINA LWGRTTLKRE DKSPIAPEEL ALVHNLRKMM KNDWHGGAIV SALSQTGSLF KPR KAYLPQ ELLGKEGFDA LDPFIPILVS NYNPKEFESC IQYYLENNWL QHEKAPTEEG KKELLFLSNA NPSLLERHCA YL

UniProtKB: Small ribosomal subunit protein mS29

Macromolecule #76: Small ribosomal subunit protein mS31

• Macromolecule: Name: Small ribosomal subunit protein mS31 / type: protein_or_peptide / ID: 76 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 45.391473 KDa

Sequence

String:

MFPRVSTFLP LRPLSRHPLS SGSPETSAAA IMLLTVRHGT VRYRSSALLA RTKNNIQRYF GTNSVICSKK DKQSVRTEET SKETSESQD SEKENTKKDL LGIIKGMKVE LSTVNVRTTK PPKRRPLKSL EATLGRLRRA TEYAPKKRIE PLSPELVAAA S AVADSLPF DKQTTKSELL SQLQQHEEES RAQRDAKRPK ISFSNIISDM KVARSATARV RSRPELRIQF DEGYDNYPGQ EK TDDLKKR KNIFTGKRLN IFDMMAVTKE APETDTSPSL WDVEFAKQLA TVNEQPLQNG FEELIQWTKE GKLWEFPINN EAG FDDDGS EFHEHIFLEK HLESFPKQGP IRHFMELVTC GLSKNPYLSV KQKVEHIEWF RNYFNEKKDI LKESNIQFN

UniProtKB: Small ribosomal subunit protein mS31

Macromolecule #77: Small ribosomal subunit protein mS33

• Macromolecule: Name: Small ribosomal subunit protein mS33 / type: protein_or_peptide / ID: 77 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.657776 KDa

Sequence

String:

MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLR GKEKPKKGEG KRAAKRK

UniProtKB: Small ribosomal subunit protein mS33

Macromolecule #78: Small ribosomal subunit protein mS34

• Macromolecule: Name: Small ribosomal subunit protein mS34 / type: protein_or_peptide / ID: 78 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 25.695549 KDa

Sequence

String:

MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQH DEPCYWRLTR VRPDYTAQNL DHGKAWGILT FKGKTESEAR EIEHVMYHDW RLVPKHEEEA FTAFTPAPED S LASVPYPP LLRAMIIAER QKNGDTSTEE PMLNVQRIRM EPWDYPAKQE DKGRAKGTPV

UniProtKB: Small ribosomal subunit protein mS34

Macromolecule #79: Small ribosomal subunit protein mS35

• Macromolecule: Name: Small ribosomal subunit protein mS35 / type: protein_or_peptide / ID: 79 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 36.898328 KDa

Sequence

String:

MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGY PVKKGVPMAK EGNLELLKIP NFLHLTPVAI KKHCEALKDF CTEWPAALDS DEKCEKHFPI EIDSTDYVSS G PSVRNPRA RVVVLRVKLS SLNLDDHAKK KLIKLVGERY CKTTDVLTIK TDRCPLRRQN YDYAVYLLTV LYHESWNTEE WE KSKTEAD MEEYIWENSS SERNILETLL QMKAAEKNME INKEELLGTK EIEEYKKSVV SLKNEEENEN SISQYKESVK RLL NVT

UniProtKB: Small ribosomal subunit protein mS35

Macromolecule #80: Small ribosomal subunit protein mS37

• Macromolecule: Name: Small ribosomal subunit protein mS37 / type: protein_or_peptide / ID: 80 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.498819 KDa

Sequence

String:

MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS VMMACWKQNE FRDDACRKEI QGFLDCAARA QEARKMRSI QETLGESGSL LPNKLNKLLQ RFPNKPYLS

UniProtKB: Small ribosomal subunit protein mS37

Macromolecule #81: Small ribosomal subunit protein mS38

• Macromolecule: Name: Small ribosomal subunit protein mS38 / type: protein_or_peptide / ID: 81 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.395326 KDa

Sequence

String:

MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDT GTAGTVAPPQ SYQCPPSQIG EGAEQGDEGV ADAPQIQCKN VLKIRRRKMN HHKYRKLVKK TRFLRRKVQE G RLRRKQIK FEKDLRRIWL KAGLKEAPEG WQTPKIYLRG K

UniProtKB: Small ribosomal subunit protein mS38

Macromolecule #82: Small ribosomal subunit protein mS39

• Macromolecule: Name: Small ribosomal subunit protein mS39 / type: protein_or_peptide / ID: 82 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 78.648547 KDa

Sequence

String:

MAVVSAVRWL GLRSRLGQPL TGRRAGLCEQ ARSCRFYSGS ATLSKVEGTD VTGIEEVVIP KKKTWDKVAV LQALASTVNR DTTAVPYVF QDDPYLMPAS SLESRSFLLA KKSGENVAKF IINSYPKYFQ KDIAEPHIPC LMPEYFEPQI KDISEAALKE R IELRKVKA SVDMFDQLLQ AGTTVSLETT NSLLDLLCYY GDQEPSTDYH FQQTGQSEAL EEENDETSRR KAGHQFGVTW RA KNNAERI FSLMPEKNEH SYCTMIRGMV KHRAYEQALN LYTELLNNRL HADVYTFNAL IEATVCAINE KFEEKWSKIL ELL RHMVAQ KVKPNLQTFN TILKCLRRFH VFARSPALQV LREMKAIGIE PSLATYHHII RLFDQPGDPL KRSSFIIYDI MNEL MGKRF SPKDPDDDKF FQSAMSICSS LRDLELAYQV HGLLKTGDNW KFIGPDQHRN FYYSKFFDLI CLMEQIDVTL KWYED LIPS AYFPHSQTMI HLLQALDVAN RLEVIPKIWK DSKEYGHTFR SDLREEILML MARDKHPPEL QVAFADCAAD IKSAYE SQP IRQTAQDWPA TSLNCIAILF LRAGRTQEAW KMLGLFRKHN KIPRSELLNE LMDSAKVSNS PSQAIEVVEL ASAFSLP IC EGLTQRVMSD FAINQEQKEA LSNLTALTSD SDTDSSSDSD SDTSEGK

UniProtKB: Small ribosomal subunit protein mS39

Macromolecule #84: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 84 / Number of copies: 145 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Macromolecule #85: TIGECYCLINE

• Macromolecule: Name: TIGECYCLINE / type: ligand / ID: 85 / Number of copies: 3 / Formula: T1C
• Molecular weight: Theoretical: 587.665 Da

Chemical component information

ChemComp-T1C:
TIGECYCLINE / medication, antibiotic*YM

Macromolecule #86: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 86 / Number of copies: 7 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #87: GUANOSINE-5'-DIPHOSPHATE

• Macromolecule: Name: GUANOSINE-5'-DIPHOSPHATE / type: ligand / ID: 87 / Number of copies: 1 / Formula: GDP
• Molecular weight: Theoretical: 443.201 Da

Chemical component information

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.4
• Grid: Model: Quantifoil R1.2/1.3 / Material: COPPER / Mesh: 300 / Support film - Material: CARBON / Support film - topology: CONTINUOUS / Support film - Film thickness: 2
• Vitrification: Cryogen name: ETHANE

Electron microscopy

• Microscope: FEI TITAN KRIOS
• Image recording: Film or detector model: GATAN K3 (6k x 4k) / Average electron dose: 50.0 e/Ų
• Electron beam: Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 1.0 µm
• Sample stage: Cooling holder cryogen: NITROGEN
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• Startup model: Type of model: OTHER / Details: Relion
• Final reconstruction: Applied symmetry - Point group: C₁ (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 3.3 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION / Number images used: 83274
• Initial angle assignment: Type: OTHER / Software - Name: RELION / Details: Relion
• Final angle assignment: Type: OTHER / Software - Name: RELION / Details: Relion

Atomic model buiding 1

Initial model

PDB ID:

7a5i

Chain - Source name: PDB / Chain - Initial model type: experimental model

• Refinement: Space: REAL / Protocol: RIGID BODY FIT

Output model

PDB-8xt2:
Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline