Author results

103D
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THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS
Descriptor:DNA (5'-D(*GP*TP*GP*GP*AP*AP*TP*GP*GP*AP*AP*C)-3')
Authors:Chou, S.-H., Zhu, L., Reid, B.R.
Deposit date:1994-12-16
Release date:1995-03-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs.
J.Mol.Biol., 244, 1994
104D
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DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN
Descriptor:DNA/RNA (5'-R(*CP*GP*CP*G)-D(P*TP*AP*TP*AP*CP*GP*CP*G)-3')
Authors:Zhu, L., Salazar, M., Reid, B.R.
Deposit date:1994-12-16
Release date:1995-03-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2.
Biochemistry, 34, 1995
169D
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THE SOLUTION STRUCTURE OF THE R(GCG)D(TATACCC):D(GGGTATACGC) OKAZAKI FRAGMENT CONTAINS TWO DISTINCT DUPLEX MORPHOLOGIES CONNECTED BY A JUNCTION
Descriptor:DNA (5'-D(*GP*GP*GP*TP*AP*TP*AP*CP*GP*C)-3'), DNA/RNA (5'-R(*GP*CP*G)-D(P*TP*AP*TP*AP*CP*CP*C)-3')
Authors:Salazar, M., Fedoroff, O.Y., Zhu, L., Reid, B.R.
Deposit date:1994-04-11
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the r(gcg)d(TATACCC):d(GGGTATACGC) Okazaki fragment contains two distinct duplex morphologies connected by a junction.
J.Mol.Biol., 241, 1994
1BJH
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HAIRPIN LOOPS CONSISTING OF SINGLE ADENINE RESIDUES CLOSED BY SHEARED A(DOT)A AND G(DOT)G PAIRS FORMED BY THE DNA TRIPLETS AAA AND GAG: SOLUTION STRUCTURE OF THE D(GTACAAAGTAC) HAIRPIN, NMR, 16 STRUCTURES
Descriptor:DNA (5'-D(*GP*TP*AP*CP*AP*AP*AP*GP*TP*AP*C)-3')
Authors:Chou, S.-H., Zhu, L., Gao, Z., Cheng, J.-W., Reid, B.R.
Deposit date:1997-07-25
Release date:1997-12-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Hairpin loops consisting of single adenine residues closed by sheared A.A and G.G pairs formed by the DNA triplets AAA and GAG: solution structure of the d(GTACAAAGTAC) hairpin.
J.Mol.Biol., 264, 1996
1DDP
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SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK
Descriptor:DNA (5'-D(*CP*AP*TP*AP*GP*CP*TP*AP*TP*G)-3'), Cisplatin
Authors:Zhu, L., Huang, H., Reid, B.R., Drobny, G.P., Hopkins, P.B.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a cisplatin-induced DNA interstrand cross-link.
Science, 270, 1995
1GMY
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CATHEPSIN B COMPLEXED WITH DIPEPTIDYL NITRILE INHIBITOR
Descriptor:CATHEPSIN B, 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, ...
Authors:Greenspan, P.D., Clark, K.L., Tommasi, R.A., Cowen, S.D., McQuire, L.W., Farley, D.L., van Duzer, J.H., Goldberg, R.L., Zhou, H., Du, Z., Fitt, J.J., Coppa, D.E., Fang, Z., Macchia, W., Zhu, L., Capparelli, M.P., Goldstein, R., Wigg, A.M., Doughty, J.R., Bohacek, R.S., Knap, A.K.
Deposit date:2001-09-25
Release date:2002-09-19
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design
J.Med.Chem., 44, 2001
1HOV
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SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020
Descriptor:MATRIX METALLOPROTEINASE-2, ZINC ION, CALCIUM ION, ...
Authors:Feng, Y., Likos, J.J., Zhu, L., Woodward, H., Munie, G., McDonald, J.J., Stevens, A.M., Howard, C.P., De Crescenzo, G.A., Welsch, D., Shieh, H.-S., Stallings, W.C.
Deposit date:2000-12-11
Release date:2001-12-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor
Biochim.Biophys.Acta, 1598, 2002
1JJR
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THE THREE-DIMENSIONAL STRUCTURE OF THE C-TERMINAL DNA BINDING DOMAIN OF HUMAN KU70
Descriptor:THYROID AUTOANTIGEN
Authors:Zhang, Z., Chen, Y.
Deposit date:2001-07-09
Release date:2001-10-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70.
J.Biol.Chem., 276, 2001
1LPV
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DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES
Descriptor:Doublesex protein, ZINC ION
Authors:Zhu, L., Wilken, J., Phillips, N., Narendra, U., Chan, G., Stratton, S., Kent, S., Weiss, M.A.
Deposit date:2002-05-08
Release date:2002-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.
Genes Dev., 14, 2000
1SDA
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CRYSTAL STRUCTURE OF PEROXYNITRITE-MODIFIED BOVINE CU,ZN SUPEROXIDE DISMUTASE
Descriptor:COPPER,ZINC SUPEROXIDE DISMUTASE, COPPER (II) ION, ZINC ION
Authors:Smith, C.D., Carson, M., Van Der Woerd, M., Chen, J., Ischiropoulos, H., Beckman, J.S.
Deposit date:1993-01-13
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase.
Arch.Biochem.Biophys., 299, 1992
1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
Deposit date:2004-08-12
Release date:2005-01-18
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
1XUE
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STRUCTURE OF GTGGAATGCAATGGAAC HAIRPIN, NMR, 10 STRUCTURES
Descriptor:DNA (5'-D(*GP*TP*GP*GP*AP*AP*TP*GP*CP*AP*AP*TP*GP*GP*AP*AP*C)-3')
Authors:Zhu, L., Chou, S.-H., Reid, B.R.
Deposit date:1996-08-26
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A single G-to-C change causes human centromere TGGAA repeats to fold back into hairpins.
Proc.Natl.Acad.Sci.USA, 93, 1996
1ZHU
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DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES
Descriptor:DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3')
Authors:Zhu, L., Chou, S.-H., Xu, J., Reid, B.R.
Deposit date:1996-01-24
Release date:1996-07-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA.
Nat.Struct.Biol., 2, 1995
2I2Z
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HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND ASPIRIN
Descriptor:Serum albumin, MYRISTIC ACID, 2-HYDROXYBENZOIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2I30
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HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE AND SALICYLIC ACID
Descriptor:Serum albumin, 2-HYDROXYBENZOIC ACID, MYRISTIC ACID
Authors:Yang, F., Bian, C., Zhu, L., Zhao, G., Huang, Z., Huang, M.
Deposit date:2006-08-17
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
2JOO
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THE NMR SOLUTION STRUCTURE OF RECOMBINANT RGD-HIRUDIN
Descriptor:Hirudin variant-1
Authors:Song, X., Mo, W., Liu, X., Yan, X., Song, H., Dai, L.
Deposit date:2007-03-14
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR solution structure of recombinant RGD-hirudin
Biochem.Biophys.Res.Commun., 360, 2007
2MIJ
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NMR STRUCTURE OF THE S-LINKED GLYCOPEPTIDE SUBLANCIN 168
Descriptor:SPBc2 prophage-derived bacteriocin sublancin-168, BETA-D-GLUCOSE
Authors:Garcia De Gonzalo, C.V., Zhu, L., Oman, T.J., van der Donk, W.A.
Deposit date:2013-12-13
Release date:2014-03-12
Last modified:2014-04-02
Method:SOLUTION NMR
Cite:NMR structure of the s-linked glycopeptide sublancin 168.
Acs Chem.Biol., 9, 2014
2MW3
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SOLUTION NMR STRUCTURE OF THE LASSO PEPTIDE STREPTOMONOMICIN
Descriptor:Lasso peptide
Authors:Tietz, J.I., Zhu, L., Mitchell, D.A., Metelev, M., Melby, J.O., Blair, P.M., Livnat, I., Severinov, K.
Deposit date:2014-10-24
Release date:2015-01-28
Last modified:2015-03-04
Method:SOLUTION NMR
Cite:Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
Chem.Biol., 22, 2015
2MWN
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TALIN-F3 / RIAM N-TERMINAL PEPTIDE COMPLEX
Descriptor:Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1
Authors:Yang, J., Zhu, L., Zhang, H., Hirbawi, J., Fukuda, K., Dwivedi, P., Liu, J., Byzova, T., Plow, E.F., Wu, J., Qin, J.
Deposit date:2014-11-13
Release date:2014-12-17
Last modified:2015-01-14
Method:SOLUTION NMR
Cite:Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.
Nat Commun, 5, 2014
2O2S
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THE STRUCTURE OF T. GONDII ENOYL ACYL CARRIER PROTEIN REDUCTASE IN COMPLEX WITH NAD AND TRICLOSAN
Descriptor:Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
Authors:Muench, S.P., Prigge, S.T., McLeod, R., Rafferty, J.B., Kirisits, M.J., Roberts, C.W., Mui, E.J., Rice, D.W.
Deposit date:2006-11-30
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
2O50
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THE CRYSTAL STRUCTURE OF TOXOPLASMA GONDII ENOYL ACYL CARRIER PROTEIN REDUCTASE
Descriptor:Enoyl-acyl carrier reductase
Authors:Muench, S.P., Prigge, S.T., McLeod, R., Rafferty, J.B., Rice, D.W.
Deposit date:2006-12-05
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
2OEH
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DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE MRF2-DNA COMPLEX USING PARAMAGNETIC SPIN LABELING
Descriptor:5'-D(P*TP*AP*CP*AP*AP*TP*AP*TP*AP*AP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*TP*TP*AP*TP*AP*TP*TP*GP*T)-3', AT-rich interactive domain-containing protein 5B
Authors:Cai, S., Zhu, L., Zhang, Z.
Deposit date:2006-12-29
Release date:2007-08-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Determination of the three-dimensional structure of the Mrf2-DNA complex using paramagnetic spin labeling.
Biochemistry, 46, 2007
2OFU
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X-RAY CRYSTAL STRUCTURE OF 2-AMINOPYRIMIDINE CARBAMATE 43 BOUND TO LCK
Descriptor:Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE
Authors:Huang, X.
Deposit date:2007-01-04
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity
J.Med.Chem., 49, 2006
2OFV
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CRYSTAL STRUCTURE OF AMINOQUINAZOLINE 1 BOUND TO LCK
Descriptor:Proto-oncogene tyrosine-protein kinase LCK, 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
Authors:Huang, X.
Deposit date:2007-01-04
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
J.Med.Chem., 49, 2006
2OG8
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CRYSTAL STRUCTURE OF AMINOQUINAZOLINE 36 BOUND TO LCK
Descriptor:Proto-oncogene tyrosine-protein kinase LCK, N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE
Authors:Huang, X.
Deposit date:2007-01-05
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
J.Med.Chem., 49, 2006