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4N7W
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CRYSTAL STRUCTURE OF THE SODIUM BILE ACID SYMPORTER FROM YERSINIA FREDERIKSENII
分子名称:Transporter, sodium/bile acid symporter family, CITRIC ACID, ...
著者Zhou, X., Levin, E.J., Zhou, M., New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2013-10-16
公開日2013-12-11
最終更新日2016-06-08
実験手法X-RAY DIFFRACTION (1.951 Å)
主引用文献Structural basis of the alternating-access mechanism in a bile acid transporter.
Nature, 505, 2013
4N7X
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THE E254A MUTANT OF THE SODIUM BILE ACID SYMPORTER FROM YERSINIA FREDERIKSENII
分子名称:Transporter, sodium/bile acid symporter family
著者Zhou, X., Levin, E.J., Zhou, M., New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2013-10-16
公開日2013-12-11
最終更新日2014-01-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of the alternating-access mechanism in a bile acid transporter.
Nature, 505, 2013
6AYE
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HUMAN APO-TRPML3 CHANNEL AT PH 7.4
分子名称:Mucolipin-3
著者Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2017-12-20
実験手法ELECTRON MICROSCOPY (4.06 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYF
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TRPML3/ML-SA1 COMPLEX AT PH 7.4
分子名称:Mucolipin-3, N-ACETYL-D-GLUCOSAMINE
著者Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2017-12-20
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYG
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HUMAN APO-TRPML3 CHANNEL AT PH 4.8
分子名称:Mucolipin-3
著者Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
登録日2017-09-08
公開日2017-11-08
最終更新日2017-12-20
実験手法ELECTRON MICROSCOPY (4.65 Å)
主引用文献Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
5FHD
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STRUCTURE OF BACTEROIDES SP PIF1 COMPLEXED WITH TAILED DSDNA RESULTING IN SSDNA BOUND COMPLEX
分子名称:Uncharacterized protein, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*CP*CP*GP*GP*GP*GP*CP*CP*GP*CP*GP*C)-3'), ADENOSINE-5'-DIPHOSPHATE, ...
著者Zhou, X., Ren, W., Bharath, S.R., Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHE
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CRYSTAL STRUCTURE OF BACTEROIDES PIF1 BOUND TO SSDNA
分子名称:Uncharacterized protein, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ADENOSINE-5'-DIPHOSPHATE, ...
著者Zhou, X., Ren, W., Bharath, S.R., Song, H.
登録日2015-12-22
公開日2016-03-30
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHF
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CRYSTAL STRUCTURE OF BACTEROIDES SP PIF1 IN COMPLEX WITH ADP-ALF4
分子名称:Uncharacterized protein, ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION
著者Zhou, X., Ren, W., Bharath, S.R., Song, H.
登録日2015-12-22
公開日2016-03-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHG
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STRUCTURE OF UNLIGANDED PIF1 FROM BACTEROIDES SP
分子名称:Uncharacterized protein
著者Zhou, X., Ren, W., Bharath, S.R., Song, H.
登録日2015-12-22
公開日2016-03-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
5FHH
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STRUCTURE OF HUMAN PIF1 HELICASE DOMAIN RESIDUES 200-641
分子名称:ATP-dependent DNA helicase PIF1, ADENOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION
著者Zhou, X., Ren, W., Bharath, S.R., Song, H.
登録日2015-12-22
公開日2016-03-30
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1
Cell Rep, 14, 2016
2G9F
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CRYSTAL STRUCTURE OF INTEIN-TAGGED MOUSE PNGASE C-TERMINAL DOMAIN
分子名称:peptide N-glycanase, CHLORIDE ION, GLYCEROL
著者Zhou, X., Zhao, G., Wang, L., Li, G., Lennarz, W.J., Schindelin, H.
登録日2006-03-06
公開日2006-10-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2G9G
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CRYSTAL STRUCTURE OF HIS-TAGGED MOUSE PNGASE C-TERMINAL DOMAIN
分子名称:peptide N-glycanase, SULFATE ION, GLYCEROL
著者Zhou, X., Zhao, G., Wang, L., Li, G., Lennarz, W.J., Schindelin, H.
登録日2006-03-06
公開日2006-10-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I74
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CRYSTAL STRUCTURE OF MOUSE PEPTIDE N-GLYCANASE C-TERMINAL DOMAIN IN COMPLEX WITH MANNOPENTAOSE
分子名称:PNGase, ALPHA-D-MANNOSE, ACETATE ION, ...
著者Zhou, X., Zhao, G., Wang, L., Li, G., Lennarz, W.J., Schindelin, H.
登録日2006-08-30
公開日2006-10-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2NBS
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BACKBONE 1H, 13C, AND 15N CHEMICAL SHIFT ASSIGNMENTS FOR DESIGNED PROTEIN E_1R26
分子名称:E_1r26
著者Zhou, X.
登録日2016-03-12
公開日2016-10-19
実験手法SOLUTION NMR
主引用文献Backbone 1H, 13C, and 15N Chemical Shift Assignments for designed protein E_1r26
To be Published
2QHD
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CRYSTAL STRUCTURE OF ECARPHOLIN S (SER49-PLA2) COMPLEXED WITH FATTY ACID
分子名称:Phospholipase A2, LAURIC ACID
著者Zhou, X., Tan, T.C., Valiyaveettil, S., Go, M.L., Kini, R.M., Sivaraman, J.
登録日2007-07-02
公開日2007-10-16
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Characterization of Myotoxic Ecarpholin S from Echis carinatus Venom
Biophys.J., 95, 2008
2QHE
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CRYSTAL STRUCTURE OF SER49-PLA2 (ECARPHOLIN S) FROM ECHIS CARINATUS SOCHUREKI SNAKE VENOM
分子名称:Phospholipase A2
著者Zhou, X., Valiyaveettil, S., Go, M.L., Kini, R.M., Sivaraman, J.
登録日2007-07-02
公開日2007-10-16
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Characterization of Myotoxic Ecarpholin S from Echis carinatus Venom
Biophys.J., 95, 2008
3BJW
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CRYSTAL STRUCTURE OF ECARPHOLIN S COMPLEXED WITH SURAMIN
分子名称:Phospholipase A2, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID
著者Zhou, X., Sivaraman, J.
登録日2007-12-04
公開日2007-12-18
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Characterization of Myotoxic Ecarpholin S from Echis carinatus Venom
Biophys.J., 95, 2008
3ISP
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CRYSTAL STRUCTURE OF ARGP FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:HTH-type transcriptional regulator Rv1985c/MT2039
著者Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.
登録日2009-08-27
公開日2010-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of ArgP from Mycobacterium tuberculosis Confirms Two Distinct Conformations of Full-length LysR Transcriptional Regulators and Reveals Its Function in DNA Binding and Transcriptional Regulation.
J.Mol.Biol., 2009
3O4F
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CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM E. COLI
分子名称:Spermidine synthase, SULFATE ION
著者Zhou, X., Tkaczuk, K.L., Chruszcz, M., Chua, T.K., Minor, W., Sivaraman, J.
登録日2010-07-27
公開日2010-08-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket
J.Struct.Biol., 169, 2010
5HVF
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-I83)
分子名称:Carboxypeptidase B2, VHH-i83, N-ACETYL-D-GLUCOSAMINE, ...
著者Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVG
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-A204)
分子名称:Carboxypeptidase B2, VHH-a204, N-ACETYL-D-GLUCOSAMINE, ...
著者Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVH
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TWO INHIBITORY NANOBODIES
分子名称:Carboxypeptidase B2, VHH-a204, VHH-i83, ...
著者Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
登録日2016-01-28
公開日2016-06-22
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
6J6M
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CO-CRYSTAL STRUCTURE OF BTK KINASE DOMAIN WITH ZANUBRUTINIB
分子名称:Tyrosine-protein kinase BTK, (7S)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, IMIDAZOLE
著者Zhou, X., Hong, Y.
登録日2019-01-15
公開日2019-10-23
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J.Med.Chem., 62, 2019
5WWL
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CRYSTAL STRUCTURE OF THE SCHIZOGENESIS POMBE KINETOCHORE MIS12C SUBCOMPLEX
分子名称:Centromere protein mis12, Kinetochore protein nnf1
著者Wang, C., Zhou, X., Wu, M., Zhang, X., Zang, J.
登録日2017-01-02
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3ITF
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STRUCTURAL BASIS FOR THE INHIBITORY FUNCTION OF THE CPXP ADAPTOR PROTEIN
分子名称:Periplasmic adaptor protein cpxP
著者Scheerer, P., Zhou, X., Krauss, N., Hunke, S.
登録日2009-08-28
公開日2011-01-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural Basis for Two-component System Inhibition and Pilus Sensing by the Auxiliary CpxP Protein.
J.Biol.Chem., 286, 2011