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1K9O
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CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX
Descriptor:ALASERPIN, TRYPSIN II ANIONIC
Authors:Ye, S., Cech, A.L., Belmares, R., Bergstrom, R.C., Tong, Y., Corey, D.R., Kanost, M.R., Goldsmith, E.J.
Deposit date:2001-10-29
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of a Michaelis serpin-protease complex.
Nat.Struct.Biol., 8, 2001
1P74
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CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE
Descriptor:Shikimate 5-dehydrogenase
Authors:Ye, S., von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V., McRee, D.E.
Deposit date:2003-04-30
Release date:2003-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
J.Bacteriol., 185, 2003
1P77
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CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE
Descriptor:Shikimate 5-dehydrogenase, ACETATE ION, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE
Authors:Ye, S., von Delft, F., Brooun, A., Knuth, M.W., Swanson, R.V., McRee, D.E.
Deposit date:2003-04-30
Release date:2003-08-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
J.Bacteriol., 185, 2003
1QQK
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THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7 (KERATINOCYTE GROWTH FACTOR)
Descriptor:FIBROBLAST GROWTH FACTOR 7
Authors:Ye, S., Luo, Y., Pelletier, H., McKeehan, W.L.
Deposit date:1999-06-07
Release date:2000-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
1QQL
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THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
Descriptor:FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
Authors:Ye, S., Luo, Y., Pelletier, H., McKeehan, W.L.
Deposit date:1999-06-07
Release date:2000-01-14
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
1R8J
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CRYSTAL STRUCTURE OF CIRCADIAN CLOCK PROTEIN KAIA FROM SYNECHOCOCCUS ELONGATUS
Descriptor:KaiA
Authors:Ye, S., Vakonakis, I., Sacchettini, J.C., LiWang, A.C.
Deposit date:2003-10-26
Release date:2004-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of circadian clock protein KaiA from Synechococcus elongatus
J.Biol.Chem., 279, 2004
2FY8
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CRYSTAL STRUCTURE OF MTHK RCK DOMAIN IN ITS LIGAND-FREE GATING-RING FORM
Descriptor:Calcium-gated potassium channel mthK
Authors:Ye, S., Jiang, Y.
Deposit date:2006-02-07
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels.
Cell(Cambridge,Mass.), 126, 2006
2IC1
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CRYSTAL STRUCTURE OF HUMAN CYSTEINE DIOXYGENASE IN COMPLEX WITH SUBSTRATE CYSTEINE
Descriptor:Cysteine dioxygenase type 1, FE (II) ION, CYSTEINE
Authors:Ye, S., Wu, X., Wei, L., Tang, D., Sun, P., Rao, Z.
Deposit date:2006-09-12
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An Insight into the Mechanism of Human Cysteine Dioxygenase: KEY ROLES OF THE THIOETHER-BONDED TYROSINE-CYSTEINE COFACTOR.
J.Biol.Chem., 282, 2007
3LDC
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HIGH RESOLUTION OPEN MTHK PORE STRUCTURE CRYSTALLIZED IN 100 MM K+
Descriptor:Calcium-gated potassium channel mthK, POTASSIUM ION
Authors:Ye, S.
Deposit date:2010-01-12
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore.
Nat.Struct.Mol.Biol., 17, 2010
3LDD
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HIGH RESOLUTION OPEN MTHK PORE STRUCTURE CRYSTALLIZED IN 100 MM K+ AND FURTHER SOAKED IN 99 MM NA+/1 MM K+.
Descriptor:Calcium-gated potassium channel mthK, POTASSIUM ION
Authors:Ye, S.
Deposit date:2010-01-12
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore.
Nat.Struct.Mol.Biol., 17, 2010
3LDE
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HIGH RESOLUTION OPEN MTHK PORE STRUCTURE CRYSTALLIZED IN 100 MM K+ AND FURTHER SOAKED IN 100 MM NA+.
Descriptor:Calcium-gated potassium channel mthK, SODIUM ION
Authors:Ye, S.
Deposit date:2010-01-12
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.208 Å)
Cite:Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore.
Nat.Struct.Mol.Biol., 17, 2010
4Y0Y
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TRYPSIN IN COMPLEX WITH WITH BPTI
Descriptor:Cationic trypsin, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Loll, B., Ye, S., Berger, A.A., Muelow, U., Alings, C., Wahl, M.C., Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
4Y0Z
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TRYPSIN IN COMPLEX WITH WITH BPTI MUTANT AMINOBUTYRIC ACID
Descriptor:Cationic trypsin, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Loll, B., Ye, S., Berger, A.A., Muelow, U., Alings, C., Wahl, M.C., Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
4Y10
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TRYPSIN IN COMPLEX WITH WITH BPTI MUTANT (2S)-2-AMINO-4,4-DIFLUOROBUTANOIC ACID
Descriptor:Cationic trypsin, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Loll, B., Ye, S., Berger, A.A., Muelow, U., Alings, C., Wahl, M.C., Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
4Y11
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TRYPSIN IN COMPLEX WITH WITH BPTI MUTANT (2S)-2-AMINO-4,4,4-TRIFLUOROBUTANOIC ACID
Descriptor:Cationic trypsin, Pancreatic trypsin inhibitor, SULFATE ION, ...
Authors:Loll, B., Ye, S., Berger, A.A., Muelow, U., Alings, C., Wahl, M.C., Koksch, B.
Deposit date:2015-02-06
Release date:2015-06-24
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Fluorine teams up with water to restore inhibitor activity to mutant BPTI.
Chem Sci, 6, 2015
5Y56
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FC MUTANT (K392D/K409D/D399K)
Descriptor:Immunoglobulin gamma-1 heavy chain, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Ye, S., Xu, T., Yu, J., Wang, X., Xu, T., Jin, Q., Duan, J., Wu, J., Wu, H.
Deposit date:2017-08-07
Release date:2017-09-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.653 Å)
Cite:A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line
J. Biol. Chem., 292, 2017
5H0N
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CRYSTAL STRUCTURE OF HIV-1 FUSION INHIBITOR MT-WQ-IDL BOUND TO GP41 NHR
Descriptor:HIV-1 gp41 NHR, HIV-1 fusion inhibitor MT-WQ-IDL
Authors:Zhu, Y., Ye, S., Zhang, R.
Deposit date:2016-10-06
Release date:2016-11-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors
J. Virol., 91, 2017
1J04
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STRUCTURAL MECHANISM OF ENZYME MISTARGETING IN HEREDITARY KIDNEY STONE DISEASE IN VITRO
Descriptor:alanine--glyoxylate aminotransferase, (AMINOOXY)ACETIC ACID, GLYCEROL
Authors:Zhang, X., Djordjevic, S., Bartlam, M., Ye, S., Rao, Z., Danpure, C.J.
Deposit date:2002-10-30
Release date:2003-11-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting.
Acta Crystallogr.,Sect.F, 66, 2010
1ZD7
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1.7 ANGSTROM CRYSTAL STRUCTURE OF POST-SPLICING FORM OF A DNAE INTEIN FROM SYNECHOCYSTIS SP. PCC 6803
Descriptor:DNA polymerase III alpha subunit, SULFATE ION
Authors:Sun, P., Ye, S., Ferrandon, S., Evans, T.C., Xu, M.Q., Rao, Z.
Deposit date:2005-04-14
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of an intein from the split dnaE gene of Synechocystis sp. PCC6803 reveal the catalytic model without the penultimate histidine and the mechanism of zinc ion inhibition of protein splicing
J.Mol.Biol., 353, 2005
1ZDE
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1.95 ANGSTROM CRYSTAL STRUCTURE OF A DNAE INTEIN PRECURSOR FROM SYNECHOCYSTIS SP. PCC 6803
Descriptor:DNA polymerase III alpha subunit, ZINC ION, CALCIUM ION
Authors:Sun, P., Ye, S., Ferrandon, S., Evans, T.C., Xu, M.Q., Rao, Z.
Deposit date:2005-04-14
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of an intein from the split dnaE gene of Synechocystis sp. PCC6803 reveal the catalytic model without the penultimate histidine and the mechanism of zinc ion inhibition of protein splicing
J.Mol.Biol., 353, 2005
3EB7
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CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN CRY8EA1 FROM BACILLUS THURINGIENSIS AT 2.2 ANGSTROMS RESOLUTION
Descriptor:Insecticidal Delta-Endotoxin Cry8Ea1, SULFATE ION, ACETATE ION
Authors:Guo, S., Ye, S., Song, F., Zhang, J., Wei, L., Shu, C.L.
Deposit date:2008-08-27
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Bacillus thuringiensis Cry8Ea1: An insecticidal toxin toxic to underground pests, the larvae of Holotrichia parallela.
J.Struct.Biol., 168, 2009
3JU5
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE AT 1.75-A RESOLUTION
Descriptor:Arginine kinase, MAGNESIUM ION
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
3JU6
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE IN COMPLEX WITH AMPPNP AND ARGININE
Descriptor:Arginine kinase, ARGININE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
4NJL
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CRYSTAL STRUCTURE OF MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS S2 PROTEIN FUSION CORE
Descriptor:S protein, TRIETHYLENE GLYCOL
Authors:Zhu, Y., Lu, L., Qin, L., Ye, S., Jiang, S., Zhang, R.
Deposit date:2013-11-10
Release date:2014-02-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor.
Nat Commun, 5, 2014
4PV7
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COCRYSTAL STRUCTURE OF DIPEPTIDYL-PEPTIDASE 4 WITH AN INDOLE SCAFFOLD INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine
Authors:Xiao, P., Guo, R., Huang, S., Cui, H., Ye, S., Zhang, Z.
Deposit date:2014-03-15
Release date:2015-03-18
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold
Chin.Chem.Lett., 25, 2014