Author results

6JU2
  • Download 6ju2
  • View 6ju2
Molmil generated image of 6ju2
STRUCTURE OF INFLUENZA D VIRUS POLYMERASE BOUND TO CRNA PROMOTER IN CLASS 1
Descriptor:Polymerase 3, RNA-directed RNA polymerase catalytic subunit, Polymerase PB2, ...
Authors:Peng, Q., Peng, R., Qi, J., Gao, G.F., Shi, Y.
Deposit date:2019-04-12
Release date:2019-06-12
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 2019
6JU3
  • Download 6ju3
  • View 6ju3
Molmil generated image of 6ju3
STRUCTURE OF INFLUENZA D VIRUS POLYMERASE BOUND TO CRNA PROMOTER IN CLASS 2
Descriptor:Polymerase 3, RNA-directed RNA polymerase catalytic subunit, Polymerase PB2, ...
Authors:Peng, Q., Peng, R., Qi, J., Gao, G.F., Shi, Y.
Deposit date:2019-04-12
Release date:2019-06-12
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 2019
6NZM
  • Download 6nzm
  • View 6nzm
Molmil generated image of 6nzm
BRUTONS TYROSINE KINASE IN COMPLEX WITH COMPOUND 50.
Descriptor:Tyrosine-protein kinase BTK, N-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-N'-{3-[(2R)-1-(2-hydroxyethyl)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea, 1,2-ETHANEDIOL
Authors:Marcotte, D.J.
Deposit date:2019-02-14
Release date:2019-06-12
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Bioorg.Med.Chem., 27, 2019
6JEB
  • Download 6jeb
  • View 6jeb
Molmil generated image of 6jeb
CRYSTAL STRUCTURE OF A BETA-N-ACETYLHEXOSAMINIDASE
Descriptor:Beta-N-acetylhexosaminidase, ZINC ION, ACETAMIDE
Authors:Chen, X., Wang, J.C., Liu, M.J., Yang, W.Y., Wang, Y.Z., Tang, R.P., Zhang, M.
Deposit date:2019-02-05
Release date:2019-03-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila.
Biochem. Biophys. Res. Commun., 511, 2019
6JE8
  • Download 6je8
  • View 6je8
Molmil generated image of 6je8
CRYSTAL STRUCTURE OF A BETA-N-ACETYLHEXOSAMINIDASE
Descriptor:Beta-N-acetylhexosaminidase, ZINC ION, GLYCEROL, ...
Authors:Chen, X., Wang, J.C., Liu, M.J., Yang, W.Y., Wang, Y.Z., Tang, R.P., Zhang, M.
Deposit date:2019-02-04
Release date:2019-03-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila.
Biochem. Biophys. Res. Commun., 511, 2019
6JEA
  • Download 6jea
  • View 6jea
Molmil generated image of 6jea
CRYSTAL STRUCTURE OF A BETA-N-ACETYLHEXOSAMINIDASE
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Chen, X., Wang, J.C., Liu, M.J., Yang, W.Y., Wang, Y.Z., Tang, R.P., Zhang, M.
Deposit date:2019-02-04
Release date:2019-03-13
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.275 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis of beta-N-acetylhexosaminidas from Akkermansia muciniphila.
Biochem. Biophys. Res. Commun., 511, 2019
6NPW
  • Download 6npw
  • View 6npw
Molmil generated image of 6npw
SSU72/SYMPK IN COMPLEX WITH SER2/SER5 PHOSPHORYLATED PEPTIDE
Descriptor:Symplekin, Ssu72 ortholog, LD40846p, ...
Authors:Irani, S., Zhang, Y.
Deposit date:2019-01-18
Release date:2019-04-24
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
J.Biol.Chem., 294, 2019
6J4R
  • Download 6j4r
  • View 6j4r
Molmil generated image of 6j4r
STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE REGULATOR 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, DNA (5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*TP*AP*TP*GP*G)-3'), ...
Authors:Jiang, M.Q., Sun, L.F., Isupov, M.N.
Deposit date:2019-01-10
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J5B
  • Download 6j5b
  • View 6j5b
Molmil generated image of 6j5b
STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE REGULATOR 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, DNA (5'-D(*GP*GP*TP*AP*CP*AP*GP*TP*AP*TP*AP*TP*AP*CP*CP*AP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*GP*GP*TP*AP*TP*AP*TP*AP*CP*TP*GP*TP*AP*CP*C)-3')
Authors:Jiang, M.Q., Sun, L.F., Isupov, M.N., Wu, Y.K.
Deposit date:2019-01-10
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J4K
  • Download 6j4k
  • View 6j4k
Molmil generated image of 6j4k
STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, GLYCEROL, MALONIC ACID
Authors:Jiang, M.Q., Sun, L.F.
Deposit date:2019-01-09
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J44
  • Download 6j44
  • View 6j44
Molmil generated image of 6j44
CRYSTAL STRUCTURE OF THE REDEFINED DNA-BINDING DOMAIN OF HUMAN XPA
Descriptor:DNA repair protein complementing XP-A cells, ZINC ION
Authors:Lian, F.M., Yang, X., Yang, W., Jiang, Y.L., Qian, C.
Deposit date:2019-01-07
Release date:2019-05-29
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural characterization of the redefined DNA-binding domain of human XPA.
Biochem.Biophys.Res.Commun., 514, 2019
6N9U
  • Download 6n9u
  • View 6n9u
Molmil generated image of 6n9u
STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) INTERACTING WITH PRIMASE DOMAINS OF TWO GP4 SUBUNITS BOUND TO AN RNA/DNA HYBRID AND DTTP (FROM LAGS1)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, RNA (5'-R(*AP*CP*CP*AP*G)-D(P*(DOC))-3'), ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9V
  • Download 6n9v
  • View 6n9v
Molmil generated image of 6n9v
STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS1)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9W
  • Download 6n9w
  • View 6n9w
Molmil generated image of 6n9w
STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS2)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N9X
  • Download 6n9x
  • View 6n9x
Molmil generated image of 6n9x
STRUCTURE OF BACTERIOPHAGE T7 LAGGING-STRAND DNA POLYMERASE (D5A/E7A) AND GP4 (HELICASE/PRIMASE) BOUND TO DNA INCLUDING RNA/DNA HYBRID, AND AN INCOMING DTTP (LAGS3)
Descriptor:DNA primase/helicase, DNA-directed DNA polymerase, Primer, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-12-04
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7S
  • Download 6n7s
  • View 6n7s
Molmil generated image of 6n7s
STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM II)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7T
  • Download 6n7t
  • View 6n7t
Molmil generated image of 6n7t
STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM III)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7V
  • Download 6n7v
  • View 6n7v
Molmil generated image of 6n7v
STRUCTURE OF BACTERIOPHAGE T7 GP4 (HELICASE-PRIMASE, E343Q MUTANT) IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE, AND CTP (FROM MULTIPLE LEAD COMPLEXES)
Descriptor:DNA primase/helicase, DNA (93-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7W
  • Download 6n7w
  • View 6n7w
Molmil generated image of 6n7w
STRUCTURE OF BACTERIOPHAGE T7 LEADING-STRAND DNA POLYMERASE (D5A/E7A)/TRX IN COMPLEX WITH A DNA FORK AND INCOMING DTTP (FROM MULTIPLE LEAD COMPLEXES)
Descriptor:DNA-directed DNA polymerase, TrxA, DNA (25-MER), ...
Authors:Gao, Y., Fox, T., Val, N., Yang, W.
Deposit date:2018-11-28
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7I
  • Download 6n7i
  • View 6n7i
Molmil generated image of 6n7i
STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (GP4(5)-DNA)
Descriptor:DNA primase/helicase, DNA (25-MER), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-27
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6N7N
  • Download 6n7n
  • View 6n7n
Molmil generated image of 6n7n
STRUCTURE OF BACTERIOPHAGE T7 E343Q MUTANT GP4 HELICASE-PRIMASE IN COMPLEX WITH SSDNA, DTTP, AC DINUCLEOTIDE AND CTP (FORM I)
Descriptor:DNA primase/helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Gao, Y., Cui, Y., Zhou, Z., Yang, W.
Deposit date:2018-11-27
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures and operating principles of the replisome.
Science, 363, 2019
6M7T
  • Download 6m7t
  • View 6m7t
Molmil generated image of 6m7t
HUMAN DNA POLYMERASE ETA IN A NON-PRODUCTIVE TERNARY COMPLEX WITH CA2+ AND DTTP OPPOSITING CDA
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*AP*TP*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
Authors:Weng, P., Gao, Y., Yang, W.
Deposit date:2018-08-21
Release date:2018-09-12
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7U
  • Download 6m7u
  • View 6m7u
Molmil generated image of 6m7u
HUMAN DNA POLYMERASE ETA IN A NON-PRODUCTIVE TERNARY COMPLEX WITH MG2+ AND DTMPNPP OPPOSITING CDA
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*AP*TP*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
Authors:Weng, P., Gao, Y., Yang, W.
Deposit date:2018-08-21
Release date:2018-09-12
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7V
  • Download 6m7v
  • View 6m7v
Molmil generated image of 6m7v
HUMAN DNA POLYMERASE ETA EXTENSION COMPLEX WITH CDA AT THE -1 POSITION
Descriptor:DNA polymerase eta, DNA (5'-D(P*GP*TP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
Authors:Weng, P., Gao, Y., Yang, W.
Deposit date:2018-08-21
Release date:2018-09-12
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.062 Å)
Cite:Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6M7O
  • Download 6m7o
  • View 6m7o
Molmil generated image of 6m7o
HUMAN DNA POLYMERASE ETA TERNARY COMPLEX WITH MN2+ AND DTMPNPP OPPOSITING CDA
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*TP*(02I)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(P*AP*GP*TP*GP*TP*GP*AP*G*(1FZ))-3'), ...
Authors:Weng, P., Gao, Y., Yang, W.
Deposit date:2018-08-20
Release date:2018-09-12
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018