Author results

5ZTM
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CRYSTAL STRUCTURE OF MLE DSRBDS IN COMPLEX WITH ROX2 (R2H1)
Descriptor:Dosage compensation regulator, non-coding mRNA sequence roX2
Authors:Lv, M.Q., Tang, Y.J.
Deposit date:2018-05-04
Release date:2019-03-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
Nucleic Acids Res., 47, 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
5YN5
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CRYSTAL STRUCTURE OF MERS-COV NSP10/NSP16 COMPLEX
Descriptor:nsp16 protein, nsp10 protein, ZINC ION
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YN6
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CRYSTAL STRUCTURE OF MERS-COV NSP10/NSP16 COMPLEX BOUND TO SAM
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYLMETHIONINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.947 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YN8
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAH
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Chen, Y., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNB
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SINEFUNGIN
Descriptor:nsp16 protein, nsp10 protein, SINEFUNGIN, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Chen, Y., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNF
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Chen, Y., Guo, D.Y.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.791 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNI
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAM AND M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYLMETHIONINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Chen, Y., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNJ
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Chen, Y., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNM
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAM AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYLMETHIONINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNN
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10COMPLEX BOUND TO SINEFUNGIN AND M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, SINEFUNGIN, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNO
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAH AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNP
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SINEFUNGIN AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, SINEFUNGIN, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNQ
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAH AND M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.958 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
6AJ0
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION
Descriptor:Viral protein 1, Virion protein 2, Capsid protein VP3, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-25
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ2
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THE STRUCTURE OF ICAM-5 TRIGGERED ENTEROVIRUS D68 VIRUS A-PARTICLE
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ3
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THE STRUCTURE OF ENTEROVIRUS D68 PROCAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ7
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5
Descriptor:VL of Fab 15C5, VH of Fab 15C5, Capsid protein VP1, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ9
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1
Descriptor:VL of Fab 11G1, VH of Fab 11G1, VL of Fab 15C5, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6BG3
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STRUCTURE OF (3S,4S)-1-BENZYL-4-(3-(3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PIPERIDIN-3-YL ACETATE BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6BG5
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STRUCTURE OF 1-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)-1-(1-PROPYLPIPERIDIN-4-YL)-3-(3-(TRIFLUOROMETHYL)PHENYL)UREA BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
5ZLU
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RIBOSOME STRUCTURE BOUND TO ABC-F PROTEIN.
Descriptor:RNA (25-mer), 30S ribosomal protein S17, 30S ribosomal protein S18, ...
Authors:Su, W.X., Kumar, V., Ero, R., Andrew, S.W.W., Jian, S., Yong-Gui, G.
Deposit date:2018-03-29
Release date:2018-08-01
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ribosome protection by antibiotic resistance ATP-binding cassette protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BR1
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4A
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-29
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BRF
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4B
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-30
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018