Author results

6WFU
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BATAAV-10HB - EMPTY PARTICLES
Descriptor:VP1 capsid
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2020-04-04
Release date:2020-06-24
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural characterization of a bat Adeno-associated virus capsid.
J.Struct.Biol., 2020
6WFT
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BATAAV-10HB - GENOME-CONTAINING PARTICLES
Descriptor:VP1 capsid, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2020-04-04
Release date:2020-06-24
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural characterization of a bat Adeno-associated virus capsid.
J.Struct.Biol., 2020
6U28
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CRYSTAL STRUCTURE OF 1918 NS1-ED W187A IN COMPLEX WITH THE P85-BETA-ISH2 DOMAIN OF HUMAN PI3K
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Cho, J.H., Zhao, B., Savage, N., Li, P.
Deposit date:2019-08-19
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
6T8W
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COMPLEMENT FACTOR B IN COMPLEX WITH (-)-4-(1-((5,7-DIMETHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID
Descriptor:Complement factor B, SULFATE ION, 5,7-dimethyl-4-[[(2~{S})-2-phenylpiperidin-1-yl]methyl]-1~{H}-indole, ...
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Sweeney, A.M., Wiesmann, C., Adams, C., Mainolfi, N., Liao, S.M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Wu, M.S., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., Erkenez, A.D., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Wiesmann, C., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2020-07-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6T8V
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COMPLEMENT FACTOR B IN COMPLEX WITH (S)-5,7-DIMETHYL-4-((2-PHENYLPIPERIDIN-1-YL)METHYL)-1H-INDOLE
Descriptor:Complement factor B, SULFATE ION, 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, ...
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Mac Sweeney, A., Wiesmann, C., Adams, C., Mainolfi, N., Liao, S.-M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Serrano-Wu, M., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., De Erkenez, A., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Wiesmann, C., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2020-07-01
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6T8U
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COMPLEMENT FACTOR B IN COMPLEX WITH 5-BROMO-3-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-7-METHYL-1H-INDOL-4-AMINE
Descriptor:Complement factor B, 5-bromanyl-3-chloranyl-~{N}-(1~{H}-imidazol-2-yl)-7-methyl-1~{H}-indol-4-amine, SULFATE ION
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Mac Sweeney, A., Wiesmann, C., Adams, C., Liao, S.-M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Serrano-Wu, M., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., De Erkenez, A., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2020-07-01
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6PMD
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ACYLDEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, SHV-WFP-SER-PRO-YCP-ALA-MP8 Acyldepsipeptide, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2019-07-01
Release date:2019-11-06
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 5, 2019
6PKA
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH UREADEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, OO1-WFP-SER-PRO-YCP-ALA-MP8 ureadepsipeptide
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2019-06-28
Release date:2019-11-06
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 5, 2019
6PEH
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CRYSTAL STRUCTURE OF RABBIT MONOCLONAL ANTI-HIV ANTIBODY 1C2
Descriptor:1C2 Fab Heavy Chain, 1C2 Fab Light Chain, SULFATE ION
Authors:Liban, T., Pancera, M.
Deposit date:2019-06-20
Release date:2019-11-20
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Immunity, 51, 2019
6P65
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HIV ENV 16055 NFL TD 2CC+ IN COMPLEX WITH ANTIBODY 1C2 FRAGMENT ANTIGEN BINDING
Descriptor:HIV Env 16055 NFL TD 2CC+, Rabbit antibody 1C2 heavy chain fragment antigen binding, Rabbit antibody 1C2 kappa chain, ...
Authors:Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2019-05-31
Release date:2019-11-20
Last modified:2020-04-01
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Immunity, 51, 2019
6P62
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HIV ENV BG505 NFL TD+ IN COMPLEX WITH ANTIBODY E70 FRAGMENT ANTIGEN BINDING
Descriptor:HIV-1 Env BG505 NFL TD+, Rabbit monoclonal antibody E70 heavy chain fragment antigen binding, Rabbit monoclonal antibody E70 kappa chain, ...
Authors:Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2019-05-31
Release date:2019-11-20
Last modified:2020-04-01
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Immunity, 51, 2019
6OX7
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THE COMPLEX OF 1918 NS1-ED AND THE ISH2 DOMAIN OF THE HUMAN P85BETA SUBUNIT OF PI3K
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Shen, Q., Zhao, B., Li, P., Cho, J.H.
Deposit date:2019-05-13
Release date:2020-04-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
6NEF
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OUTER MEMBRANE CYTOCHROME S FILAMENT FROM GEOBACTER SULFURREDUCENS
Descriptor:C-type cytochrome OmcS, HEME C, MAGNESIUM ION
Authors:Filman, D.J., Marino, S.F., Ward, J.E., Yang, L., Mester, Z., Bullitt, E., Lovley, D.R., Strauss, M.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.
Commun Biol, 2, 2019
6N47
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THE STRUCTURE OF SB-2-204-TUBULIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Arnst, K., Banerjee, S., Wang, Y., Li, W., Miller, D., Li, W.
Deposit date:2018-11-17
Release date:2019-11-13
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors.
Acs Chem.Biol., 14, 2019
6LN2
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CRYSTAL STRUCTURE OF FULL LENGTH HUMAN GLP1 RECEPTOR IN COMPLEX WITH FAB FRAGMENT (FAB7F38)
Descriptor:Glucagon-like peptide 1 receptor,Rubredoxin,Glucagon-like peptide 1 receptor, Fab7F38_light chain, Fab7F38_heavy chain, ...
Authors:Wu, F., Yang, L., Hang, K., Laursen, M., Wu, L., Han, G.W., Ren, Q., Roed, N.K., Lin, G., Hanson, M., Jiang, H., Wang, M., Reedtz-Runge, S., Song, G., Stevens, R.C.
Deposit date:2019-12-28
Release date:2020-03-18
Last modified:2020-03-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Full-length human GLP-1 receptor structure without orthosteric ligands.
Nat Commun, 11, 2020
6LHT
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LOCALIZED RECONSTRUCTION OF COXSACKIEVIRUS A16 MATURE VIRION IN COMPLEX WITH FAB 18A7
Descriptor:light chain variable region of Fab 18A7, heavy chain variable region of Fab 18A7, VP1 protein, ...
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-10
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHQ
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 MATURE VIRION IN COMPLEX WITH FAB NA9D7
Descriptor:VP1 protein, VP2 protein, VP3 protein, ...
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-09
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHP
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 MATURE VIRION IN COMPLEX WITH FAB 14B10
Descriptor:light chain variable region of Fab 14B10, heavy chain variable region of Fab 14B10, VP1 protein, ...
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-09
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHO
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 EMPTY PARTICLE IN COMPLEX WITH FAB 18A7
Descriptor:VP1 protein, VP2 protein, VP3 protein
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-09
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHL
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 A-PARTICLE IN COMPLEX WITH FAB 18A7
Descriptor:VP1 protein, VP2 protein, VP3 protein
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-09
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHK
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 MATURE VIRION IN COMPLEX WITH FAB 18A7
Descriptor:VP1 protein, VP2 protein, VP3 protein, ...
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-09
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHC
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 EMPTY PARTICLE
Descriptor:VP1, VP2, VP3
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-07
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHB
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 A-PARTICLE
Descriptor:VP1, VP2, VP3
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-07
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6LHA
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THE CRYO-EM STRUCTURE OF COXSACKIEVIRUS A16 MATURE VIRION
Descriptor:VP1 protein, VP2 protein, VP3 protein, ...
Authors:He, M.Z., Xu, L.F., Zheng, Q.B., Zhu, R., Yin, Z.C., Cheng, T., Li, S.W.
Deposit date:2019-12-07
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16.
Cell Host Microbe, 27, 2020
6JN2
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAINS OF HUMAN DOT1L IN COMPLEX WITH AF10
Descriptor:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific
Authors:Song, X., Wang, M., Yang, N., Xu, R.M.
Deposit date:2019-03-13
Release date:2019-09-18
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Proc.Natl.Acad.Sci.USA, 116, 2019