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1DQF
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CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS
Descriptor:RNA (5'-R(*GP*CP*CP*AP*CP*CP*CP*UP*G)-3'), RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3'), CALCIUM ION
Authors:Xiong, Y., Sundaralingam, M.
Deposit date:2000-01-04
Release date:2000-11-13
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
RNA, 6, 2000
1DQH
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CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS
Descriptor:RNA (5'-R(*GP*CP*CP*AP*CP*CP*CP*UP*G)-3'), RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3')
Authors:Xiong, Y., Sundaralingam, M.
Deposit date:2000-01-04
Release date:2000-11-13
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Two crystal forms of helix II of Xenopus laevis 5S rRNA with a cytosine bulge.
RNA, 6, 2000
1J9H
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CRYSTAL STRUCTURE OF AN RNA DUPLEX WITH URIDINE BULGES
Descriptor:5'-R(*GP*UP*GP*UP*CP*GP*(CBR)P*AP*C)-3', CALCIUM ION
Authors:Xiong, Y., Deng, J., Sudarsanakumar, C., Sundaralingam, M.
Deposit date:2001-05-25
Release date:2001-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of an RNA duplex r(gugucgcac)(2) with uridine bulges.
J.Mol.Biol., 313, 2001
1JZV
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CRYSTAL STRUCTURE OF A BULGED RNA FROM THE SL2 STEM-LOOP OF THE HIV-1 PSI-RNA
Descriptor:5'-R(*GP*GP*CP*GP*AP*CP*(5BU)P*G)-3', 5'-R(*CP*AP*GP*UP*AP*CP*GP*(5IC)P*C)-3', MAGNESIUM ION
Authors:Xiong, Y., Sudarsanakumar, C., Deng, J., Pan, B., Sundaralingam, M.
Deposit date:2001-09-17
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of a Bulged RNA from the SL2 Stem-loop of the HIV-1 psi-RNA
To be Published
1R89
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CRYSTAL STRUCTURES OF AN ARCHAEAL CLASS I CCA-ADDING ENZYME AND ITS NUCLEOTIDE COMPLEXES
Descriptor:tRNA nucleotidyltransferase, MANGANESE (II) ION, SODIUM ION, ...
Authors:Xiong, Y., Li, F., Wang, J., Weiner, A.M., Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8A
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CRYSTAL STRUCTURES OF AN ARCHAEAL CLASS I CCA-ADDING ENZYME AND ITS NUCLEOTIDE COMPLEXES
Descriptor:tRNA nucleotidyltransferase, MANGANESE (II) ION, SODIUM ION
Authors:Xiong, Y., Li, F., Wang, J., Weiner, A.M., Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8B
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CRYSTAL STRUCTURES OF AN ARCHAEAL CLASS I CCA-ADDING ENZYME AND ITS NUCLEOTIDE
Descriptor:tRNA nucleotidyltransferase, MANGANESE (II) ION, MAGNESIUM ION, ...
Authors:Xiong, Y., Li, F., Wang, J., Weiner, A.M., Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1R8C
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CRYSTAL STRUCTURES OF AN ARCHAEAL CLASS I CCA-ADDING ENZYME AND ITS NUCLEOTIDE
Descriptor:tRNA nucleotidyltransferase, MANGANESE (II) ION, SODIUM ION, ...
Authors:Xiong, Y., Li, F., Wang, J., Weiner, A.M., Steitz, T.A.
Deposit date:2003-10-23
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell, 12, 2003
1SZ1
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MECHANISM OF CCA-ADDING ENZYMES SPECIFICITY REVEALED BY CRYSTAL STRUCTURES OF TERNARY COMPLEXES
Descriptor:T-RNA (76-MER), tRNA nucleotidyltransferase
Authors:Xiong, Y., Steitz, T.A.
Deposit date:2004-04-02
Release date:2004-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (6.21 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
1TFW
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HOW CCA IS ADDED TO THE 3' END OF IMMATURE TRNA WITHOUT THE USE OF AN OLIGONUCLEOTIDE TEMPLATE
Descriptor:5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3', 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*CP*C)-3', 5'-R(*GP*CP*GP*GP*AP*CP*CP*CP*GP*CP*AP*C)-3', ...
Authors:Xiong, Y., Steitz, T.A.
Deposit date:2004-05-27
Release date:2004-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
1TFY
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HOW CCA IS ADDED TO THE 3' END OF IMMATURE TRNA WITHOUT THE USE OF AN OLIGONUCLEOTIDE TEMPLATE
Descriptor:5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*G)-3', 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*AP*C)-3', 5'-R(*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3', ...
Authors:Xiong, Y., Steitz, T.A.
Deposit date:2004-05-27
Release date:2004-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template.
Nature, 430, 2004
2PFF
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STRUCTURAL INSIGHTS OF YEAST FATTY ACID SYNTHASE
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Tail protein
Authors:Xiong, Y., Lomakin, I.B., Steitz, T.A.
Deposit date:2007-04-04
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural Insights of Yeast Fatty Acid Synthase
Cell(Cambridge,Mass.), 129, 2007
421D
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5'-D(*TP*TP*CP*TP*TP*(BRO)CP*TP*TP*C)-3', 5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3'
Descriptor:DNA (5'-D(*TP*TP*CP*TP*TP*(CBR)P*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3')
Authors:Xiong, Y., Sundaralingam, M.
Deposit date:1998-08-16
Release date:1999-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and conformation of a DNA-RNA hybrid duplex with a polypurine RNA strand: d(TTCTTBr5CTTC)-r(GAAGAAGAA).
Structure, 6, 1998
479D
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CRYSTAL STRUCTURE A DNA:RNA HYBRID DUPLEX, A DYNAMIC MODEL FOR RNASE H RECOGNITION
Descriptor:DNA (5'-D(*CP*TP*CP*TP*TP*CP*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3')
Authors:Xiong, Y., Sundaralingam, M.
Deposit date:1999-07-08
Release date:2000-05-15
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary polypyrimidine DNA d(CTCTTCTTC).
Nucleic Acids Res., 28, 2000
5KYK
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COVALENT GTP-COMPETITIVE INHIBITORS OF KRAS G12C: GUANOSINE BISPHOSPHONATE ANALOGS
Descriptor:GTPase KRas, 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine
Authors:Xiong, Y., Lu, J., Hunter, J., Li, L., Scott, D., Manandhar, A., Gondi, S., Westover, K.D., Gray, N.S.
Deposit date:2016-07-21
Release date:2017-04-12
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
3G8Q
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A CYTIDINE DEAMINASE EDITS C-TO-U IN TRANSFER RNAS IN ARCHAEA
Descriptor:Predicted RNA-binding protein, contains THUMP domain, ZINC ION, ...
Authors:Xiong, Y., Stanley, B.J.
Deposit date:2009-02-12
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A cytidine deaminase edits C to U in transfer RNAs in Archaea
Science, 324, 2009
3MQ7
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CRYSTAL STRUCTURE OF ECTODOMAIN MUTANT OF BST-2/TETHERIN/CD317
Descriptor:Bone marrow stromal antigen 2, CALCIUM ION
Authors:Xiong, Y., Yang, H., Wang, J., Meng, W.
Deposit date:2010-04-27
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MQ9
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CRYSTAL STRUCTURE OF ECTODOMAIN MUTANT OF BST-2/TETHERIN/CD317 FUSED TO MBP
Descriptor:Bone marrow stromal antigen 2 fused to Maltose-binding periplasmic protein
Authors:Xiong, Y., Yang, H., Wang, J., Meng, W.
Deposit date:2010-04-27
Release date:2010-10-27
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MQB
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CRYSTAL STRUCTURE OF ECTODOMAIN OF BST-2/TETHERIN/CD317 (C2)
Descriptor:Bone marrow stromal antigen 2
Authors:Xiong, Y., Yang, H., Wang, J., Meng, W.
Deposit date:2010-04-27
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MQC
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CRYSTAL STRUCTURE OF ECTODOMAIN OF BST-2/TETHERIN/CD317 (P21)
Descriptor:Bone marrow stromal antigen 2
Authors:Xiong, Y., Yang, H., Wang, J., Meng, W.
Deposit date:2010-04-27
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Proc.Natl.Acad.Sci.USA, 107, 2010
4WHJ
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MYXOVIRUS RESISTANCE PROTEIN 2 (MXB)
Descriptor:Interferon-induced GTP-binding protein Mx2
Authors:Xiong, Y., Fribourgh, J.L., Nguyen, H.C.
Deposit date:2014-09-22
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into HIV-1 Restriction by MxB.
Cell Host Microbe, 16, 2014
5TTF
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF G9A WITH MS012
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:DONG, A., ZENG, H., LIU, J., XIONG, Y., BABAULT, N., JIN, J., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., WU, H., BROWN, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2016-12-21
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TTG
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF GLP WITH MS012
Descriptor:Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine, ...
Authors:DONG, A., ZENG, H., LIU, J., XIONG, Y., BABAULT, N., JIN, J., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., WU, H., BROWN, P.J., Structural Genomics Consortium (SGC)
Deposit date:2016-11-03
Release date:2017-02-01
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TUY
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STRUCTURE OF HUMAN G9A SET-DOMAIN (EHMT2) IN COMPLEX WITH INHIBITOR MS0124
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Babault, N., Xiong, Y., Liu, J., Jin, J.
Deposit date:2016-11-07
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017
5TUZ
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STRUCTURE OF HUMAN GLP SET-DOMAIN (EHMT1) IN COMPLEX WITH INHIBITOR MS0124
Descriptor:Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, ZINC ION, ...
Authors:Babault, N., Xiong, Y., Liu, J., Jin, J.
Deposit date:2016-11-07
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
J. Med. Chem., 60, 2017