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6N3I
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CRYSTAL STRUCTURE OF A DOUBLE TRP XYLE MUTANTS (G58W/L315W)
Descriptor:D-xylose transporter
Authors:Jiang, X., Wu, J.P., Yan, N.
Deposit date:2018-11-15
Release date:2019-03-27
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs.
Cell Discov, 5, 2019
6A95
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COMPLEX OF VOLTAGE-GATED SODIUM CHANNEL NAVPAS FROM AMERICAN COCKROACH PERIPLANETA AMERICANA BOUND WITH TETRODOTOXIN AND DC1A
Descriptor:Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Shen, H.Z., li, Z.Q., Jiang, Y., Pan, X.J., Wu, J.P., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K.Y., Lei, J.L., Zhou, Q., King, G.F., Yan, N.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
6A91
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COMPLEX OF VOLTAGE-GATED SODIUM CHANNEL NAVPAS FROM AMERICAN COCKROACH PERIPLANETA AMERICANA BOUND WITH SAXITOXIN AND DC1A
Descriptor:Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Shen, H.Z., li, Z.Q., Jiang, Y., Pan, X.J., Wu, J.P., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K.Y., Lei, J.L., Zhou, Q., King, G.F., Yan, N.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
6A90
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COMPLEX OF VOLTAGE-GATED SODIUM CHANNEL NAVPAS FROM AMERICAN COCKROACH PERIPLANETA AMERICANA AND DC1A
Descriptor:Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Shen, H.Z., li, Z.Q., Jiang, Y., Pan, X.J., Wu, J.P., Cristofori-Armstrong, B., Smith, J.J., Chin, Y.K.Y., Lei, J.L., Zhou, Q., King, G.F., Yan, N.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for the modulation of voltage-gated sodium channels by animal toxins.
Science, 362, 2018
5XSY
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STRUCTURE OF THE NAV1.4-BETA1 COMPLEX FROM ELECTRIC EEL
Descriptor:Sodium channel protein, Voltage-gated sodium channel beta subunit 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Yan, Z., Zhou, Q., Wu, J.P., Yan, N.
Deposit date:2017-06-15
Release date:2017-08-09
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of the Nav1.4-beta 1 Complex from Electric Eel.
Cell, 170, 2017
5JNX
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THE 6.6 A CRYO-EM STRUCTURE OF THE FULL-LENGTH HUMAN NPC1 IN COMPLEX WITH THE CLEAVED GLYCOPROTEIN OF EBOLA VIRUS
Descriptor:Niemann-Pick C1 protein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gong, X., Qian, H.W., Zhou, X.H., Wu, J.P., Wan, T., Shi, Y., Gao, F., Zhou, Q., Yan, N.
Deposit date:2016-05-01
Release date:2016-06-15
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (6.56 Å)
Cite:Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
Cell, 165, 2016
5GXB
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CRYSTAL STRUCTURE OF A LACY/NANOBODY COMPLEX
Descriptor:Lactose permease, nanobody
Authors:Jiang, X., Wu, J.P., Yan, N., Kaback, H.R.
Deposit date:2016-09-16
Release date:2016-10-26
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.
Proc.Natl.Acad.Sci.USA, 113, 2016
5GRS
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COMPLEX STRUCTURE OF THE FISSION YEAST SREBP-SCAP BINDING DOMAINS
Descriptor:Sterol regulatory element-binding protein cleavage-activating protein, Sterol regulatory element-binding protein 1
Authors:Gong, X., Qian, H.W., Wu, J.P., Yan, N.
Deposit date:2016-08-12
Release date:2016-12-14
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
5GPD
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CRYSTAL STRUCTURE OF THE BINDING DOMAIN OF SREBP FROM FISSION YEAST
Descriptor:Sterol regulatory element-binding protein 1
Authors:Gong, X., Qian, H.W., Wu, J.P., Yan, N.
Deposit date:2016-08-01
Release date:2016-11-23
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cell Res., 26, 2016
5GOA
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CRYO-EM STRUCTURE OF RYR2 IN OPEN STATE
Descriptor:RyR2, ZINC ION
Authors:Peng, W., Wu, J.P., Yan, N.
Deposit date:2016-07-26
Release date:2016-10-05
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
Science, 354, 2016
5GO9
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CRYO-EM STRUCTURE OF RYR2 IN CLOSED STATE
Descriptor:RyR2, ZINC ION
Authors:Peng, W., Wu, J.P., Yan, N.
Deposit date:2016-07-26
Release date:2016-10-05
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
Science, 354, 2016
5GL1
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STRUCTURE OF RYR1 IN AN OPEN STATE
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ZINC ION
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2019-10-16
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GL0
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STRUCTURE OF RYR1 IN A CLOSED STATE (C4 CONFORMER)
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ZINC ION
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2019-10-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GKZ
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STRUCTURE OF RYR1 IN A CLOSED STATE (C3 CONFORMER)
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ZINC ION
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2019-10-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GKY
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STRUCTURE OF RYR1 IN A CLOSED STATE (C1 CONFORMER)
Descriptor:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ZINC ION
Authors:Bai, X.C., Yan, Z., Wu, J.P., Yan, N.
Deposit date:2016-07-07
Release date:2016-08-24
Last modified:2019-10-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
5GJW
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STRUCTURE OF THE MAMMALIAN VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX FOR CLASSII MAP
Descriptor:Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel gamma-1 subunit, ...
Authors:Wu, J.P., Yan, Z., Li, Z.Q., Zhou, Q., Yan, N.
Deposit date:2016-07-02
Release date:2016-09-14
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
Nature, 537, 2016
5GJV
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STRUCTURE OF THE MAMMALIAN VOLTAGE-GATED CALCIUM CHANNEL CAV1.1 COMPLEX AT NEAR ATOMIC RESOLUTION
Descriptor:Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel gamma-1 subunit, ...
Authors:Wu, J.P., Yan, Z., Li, Z.Q., Zhou, Q., Yan, N.
Deposit date:2016-07-02
Release date:2016-09-14
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
Nature, 537, 2016
5GJR
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AN ATOMIC STRUCTURE OF THE HUMAN 26S PROTEASOME
Descriptor:26S protease regulatory subunit 4, 26S protease regulatory subunit 7, 26S protease regulatory subunit 10B, ...
Authors:Huang, X.L., Luan, B., Wu, J.P., Shi, Y.G.
Deposit date:2016-07-01
Release date:2016-09-07
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
5GJQ
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STRUCTURE OF THE HUMAN 26S PROTEASOME BOUND TO USP14-UBAL
Descriptor:Proteasome subunit beta type-6, Proteasome subunit alpha type-6, Proteasome subunit beta type-7, ...
Authors:Huang, X.L., Luan, B., Wu, J.P., Shi, Y.G.
Deposit date:2016-07-01
Release date:2016-08-17
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
5FCG
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CRYSTAL STRUCTURE OF BCL-2 IN COMPLEX WITH HBX-BH3 MOTIF
Descriptor:Apoptosis regulator Bcl-2, Protein X
Authors:Jiang, T.Y., Liu, M.H., Wu, J.P., Shi, Y.G.
Deposit date:2015-12-15
Release date:2016-02-10
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx
Proc.Natl.Acad.Sci.USA, 2016
4YHC
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CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF SCAP FROM FISSION YEAST
Descriptor:Sterol regulatory element-binding protein cleavage-activating protein, CITRIC ACID
Authors:Gong, X., Li, J.X., Wu, J.P., Yan, C.Y., Yan, N.
Deposit date:2015-02-27
Release date:2015-04-01
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.
Cell Res., 25, 2015
4XU6
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CRYSTAL STRUCTURE OF CROSS-LINKED MVINS R77C TRIMER AT 1.9A RESOLUTION
Descriptor:Uncharacterized protein, B-OCTYLGLUCOSIDE, N-TRIDECANOIC ACID
Authors:Ren, R.B., Wu, J.P., Yan, C.Y., He, Y., Yan, N.
Deposit date:2015-01-25
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Science, 349, 2015
4XU5
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CRYSTAL STRUCTURE OF MVINS BOUND TO A BROMINE-DERIVED 14C DIACYLGLYCEROL (DAG) AT 2.1A RESOLUTION
Descriptor:Uncharacterized protein, (2S)-1-[(13-bromotridecanoyl)oxy]-3-hydroxypropan-2-yl tetradecanoate, DECANE, ...
Authors:Ren, R.B., Wu, J.P., Yan, C.Y., He, Y., Yan, N.
Deposit date:2015-01-25
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Science, 349, 2015
4XU4
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CRYSTAL STRUCTURE OF A MYCOBACTERIAL INSIG HOMOLOG MVINS FROM MYCOBACTERIUM VANBAALENII AT 1.9A RESOLUTION
Descriptor:Uncharacterized protein, B-NONYLGLUCOSIDE, DECYLAMINE-N,N-DIMETHYL-N-OXIDE
Authors:Ren, R.B., Wu, J.P., Yan, C.Y., He, Y., Yan, N.
Deposit date:2015-01-25
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Science, 349, 2015
4PYP
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CRYSTAL STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT1
Descriptor:Solute carrier family 2, facilitated glucose transporter member 1, B-NONYLGLUCOSIDE
Authors:Deng, D., Yan, C.Y., Xu, C., Wu, J.P., Sun, P.C., Hu, M.X., Yan, N.
Deposit date:2014-03-27
Release date:2014-05-21
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (3.166 Å)
Cite:Crystal structure of the human glucose transporter GLUT1
Nature, 510, 2014
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