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3IYJ
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BOVINE PAPILLOMAVIRUS TYPE 1 OUTER CAPSID
Descriptor:Major capsid protein L1
Authors:Wolf, M., Garcea, R.L., Grigorieff, N., Harrison, S.C.
Deposit date:2009-12-15
Release date:2010-01-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Subunit interactions in bovine papillomavirus.
Proc.Natl.Acad.Sci.USA, 107, 2010
6CX1
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CRYO-EM STRUCTURE OF SENECA VALLEY VIRUS-ANTHRAX TOXIN RECEPTOR 1 COMPLEX
Descriptor:Anthrax toxin receptor 1, Capsid protein VP1, Capsid protein VP2, ...
Authors:Jayawardena, N., Burga, L., Easingwood, R., Takizawa, Y., Wolf, M., Bostina, M.
Deposit date:2018-04-02
Release date:2018-10-31
Last modified:2018-11-28
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4WIA
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CRYSTAL STRUCTURE OF FLAGELLAR ACCESSORY PROTEIN FLAH FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:Putative flagella-related protein H, SULFATE ION, GLYCEROL
Authors:Meshcheryakov, V.A., Wolf, M.
Deposit date:2014-09-25
Release date:2015-10-07
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly.
Protein Sci., 25, 2016
5JXL
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CRYO-EM STRUCTURE OF THE FLAGELLAR HOOK OF CAMPYLOBACTER JEJUNI
Descriptor:flagellar hook protein FlgE
Authors:Matsunami, H., Wolf, M., Samatey, F.A.
Deposit date:2016-05-13
Release date:2016-11-16
Last modified:2018-07-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions
Nat Commun, 7, 2016
5YA6
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CRYSTAL STRUCTURE OF ARCHAEAL FLAGELLIN FLAB1 FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:Flagellin B1, CALCIUM ION
Authors:Meshcheryakov, V.A., Wolf, M.
Deposit date:2017-08-30
Release date:2019-02-06
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-resolution archaellum structure reveals a conserved metal-binding site.
Embo Rep., 20, 2019
5Z1L
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CRYO-EM STRUCTURE OF METHANOCCUS MARIPALUDIS ARCHAELLUM
Descriptor:Flagellin
Authors:Meshcheryakov, V.A., Shibata, S., Schreiber, M.T., Villar-Briones, A., Jarrell, K.F., Aizawa, S., Wolf, M.
Deposit date:2017-12-26
Release date:2019-02-13
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (4 Å)
Cite:High-resolution archaellum structure reveals a conserved metal-binding site.
Embo Rep., 20, 2019
5Z9W
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EBOLA VIRUS NUCLEOPROTEIN-RNA COMPLEX
Descriptor:Ebolavirus nucleoprotein (residues 19-406), RNA (6-MER)
Authors:Sugita, Y., Matsunami, H., Kawaoka, Y., Noda, T., Wolf, M.
Deposit date:2018-02-05
Release date:2018-10-24
Last modified:2018-11-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 angstrom resolution.
Nature, 563, 2018
6K3I
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SALMONELLA HOOK IN CURVED STATE - 66 SUBUNIT MODELS
Descriptor:Flagellar hook protein FlgE
Authors:Shibata, S., Matsunami, H., Wolf, M., Aizawa, S.
Deposit date:2019-05-19
Release date:2019-10-02
Last modified:2019-10-16
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM.
Nat.Struct.Mol.Biol., 2019
5JCJ
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR NMT-H037 (COMPOUND 7)
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETATE ION, ...
Authors:Landi, G., Pozzi, C., Di Pisa, F., Dello Iacono, L., Mangani, S.
Deposit date:2016-04-15
Release date:2016-08-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
J.Med.Chem., 59, 2016
5JCX
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR NP-29
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one, ...
Authors:Landi, G., Pozzi, C., Di Pisa, F., Dello Iacono, L., Mangani, S.
Deposit date:2016-04-15
Release date:2016-08-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
J.Med.Chem., 59, 2016
5JDC
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR NP-13 (HESPERETIN)
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one, ...
Authors:Mangani, S., Pozzi, C., Di Pisa, F., Landi, G., Dello Iacono, L.
Deposit date:2016-04-16
Release date:2016-08-17
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
J.Med.Chem., 59, 2016
5JDI
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH COFACTOR AND INHIBITOR NMT-H024 (COMPOUND 2)
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETATE ION, ...
Authors:Landi, G., Pozzi, C., Di Pisa, F., Dello lacono, L., Mangani, S.
Deposit date:2016-04-16
Release date:2016-08-17
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
J.Med.Chem., 59, 2016
2YHI
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR WH16
Descriptor:PTERIDINE REDUCTASE, PUTATIVE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Nerini, E., Dawson, A., Hunter, W.N., Costi, M.P.
Deposit date:2011-05-03
Release date:2012-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
2YHU
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR WHF30
Descriptor:PTERIDINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-THIOPHEN-2-YLPROPAN-1-ONE, ...
Authors:Nerini, E., Dawson, A., Hunter, W.N., Costi, M.P.
Deposit date:2011-05-06
Release date:2012-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
4EEH
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR 3-(4-HYDROXY-PHENYL)-1H-INDAZOL-6-OL
Descriptor:Heat shock protein HSP 90-alpha, 3-(4-hydroxyphenyl)-1H-indazol-6-ol, SULFATE ION
Authors:Musil, D., Lehmann, M., Graedler, U., Buchstaller, H.-P.
Deposit date:2012-03-28
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
Bioorg.Med.Chem.Lett., 22, 2012
4EFT
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR 3-CYCLOHEXYL-2-(6-HYDROXY-1H-INDAZOL-3-YL)-PROPIONITRILE
Descriptor:Heat shock protein HSP 90-alpha, (2R)-3-cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)propanenitrile
Authors:Musil, D., Lehmann, M., Graedler, U., Buchstaller, H.-P.
Deposit date:2012-03-30
Release date:2012-06-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
Bioorg.Med.Chem.Lett., 22, 2012
4EFU
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HSP90 ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH AN INHIBITOR 6-HYDROXY-3-(3-METHYL-BENZYL)-1H-INDAZOLE-5-CARBOXYLIC ACID BENZYL-METHYL-AMIDE
Descriptor:Heat shock protein HSP 90-alpha, N-benzyl-6-hydroxy-N-methyl-3-(3-methylbenzyl)-1H-indazole-5-carboxamide, SULFATE ION
Authors:Musil, D., Lehmann, M., Graedler, U., Buchstaller, H.-P.
Deposit date:2012-03-30
Release date:2012-06-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
Bioorg.Med.Chem.Lett., 22, 2012
4WCD
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR 10
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(1H-benzotriazol-6-yl)-1,3,4-thiadiazol-2-amine, ...
Authors:Mangani, S., Di Pisa, F., Pozzi, C.
Deposit date:2014-09-04
Release date:2015-09-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
4WCF
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR 9
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(5-amino-1,3,4-thiadiazol-2-yl)pyridin-4-amine, ...
Authors:Mangani, S., Di Pisa, F., Pozzi, C.
Deposit date:2014-09-04
Release date:2015-09-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
5IZC
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR F032
Descriptor:Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~2~-[(thiophen-2-yl)methyl]-1,3,4-thiadiazole-2,5-diamine, ...
Authors:Pozzi, C., Landi, G., Di Pisa, F., Mangani, S.
Deposit date:2016-03-25
Release date:2017-04-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017