Author results

1EXP
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BETA-1,4-GLYCANASE CEX-CD
Descriptor:BETA-1,4-D-GLYCANASE CEX-CD, BETA-D-GLUCOSE, 2-deoxy-2-fluoro-alpha-D-glucopyranose
Authors:White, A., Tull, D., Johns, K.L., Withers, S.G., Rose, D.R.
Deposit date:1996-01-11
Release date:1997-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic observation of a covalent catalytic intermediate in a beta-glycosidase.
Nat.Struct.Biol., 3, 1996
1HV0
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DISSECTING ELECTROSTATIC INTERACTIONS AND THE PH-DEPENDENT ACTIVITY OF A FAMILY 11 GLYCOSIDASE
Descriptor:ENDO-1,4-BETA-XYLANASE
Authors:Joshi, M.D., Sidhu, G., Nielsen, J.E., Brayer, G.D., Withers, S.G., McIntosh, L.P.
Deposit date:2001-01-05
Release date:2001-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
Biochemistry, 40, 2001
1JAK
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (IFG)
Descriptor:Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ...
Authors:Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.
Deposit date:2001-05-30
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276, 2001
1BSI
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HUMAN PANCREATIC ALPHA-AMYLASE FROM PICHIA PASTORIS, GLYCOSYLATED PROTEIN
Descriptor:ALPHA-AMYLASE, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Rydberg, E.H., Sidhu, G., Vo, H.C., Hewitt, J., Cote, H.C.F., Wang, Y., Numao, S., Macgillivray, R.T.A., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.
Protein Sci., 8, 1999
1C5H
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HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF A GLYCOSIDASE
Descriptor:ENDO-1,4-BETA-XYLANASE
Authors:Joshi, M.D., Sidhu, G., Pot, I., Brayer, G.D., Withers, S.G., Mcintosh, L.P.
Deposit date:1999-11-24
Release date:2000-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
J.Mol.Biol., 299, 2000
1C5I
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HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF A GLYCOSIDASE
Descriptor:ENDO-1,4-BETA-XYLANASE, BETA-D-XYLOPYRANOSE, 1,2-DEOXY-2-FLUORO-XYLOPYRANOSE
Authors:Joshi, M.D., Sidhu, G., Pot, I., Brayer, G.D., Withers, S.G., Mcintosh, L.P.
Deposit date:1999-11-24
Release date:2000-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
J.Mol.Biol., 299, 2000
1CPU
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SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor:PROTEIN (ALPHA-AMYLASE), ALPHA-D-GLUCOSE, 4,6-DIDEOXY-4-AMINO-ALPHA-D-GLUCOSE, ...
Authors:Brayer, G.D., Sidhu, G., Maurus, R., Rydberg, E.H., Braun, C., Wang, Y., Nguyen, N.T., Overall, C.M., Withers, S.G.
Deposit date:1999-06-07
Release date:1999-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
1FH7
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED INHIBITOR DEOXYNOJIRIMYCIN
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, PIPERIDINE-3,4,5-TRIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FH8
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED ISOFAGOMINE INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, PIPERIDINE-3,4-DIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FH9
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED LACTAM OXIME INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, 3,4,5-TRIHYDOXY-PIPERIDINE-2-ONE-OXIME
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1FHD
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED IMIDAZOLE INHIBITOR
Descriptor:BETA-1,4-XYLANASE, BETA-D-XYLOPYRANOSE, 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL
Authors:Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R.
Deposit date:2000-07-31
Release date:2000-08-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars.
Biochemistry, 39, 2000
1G9R
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CRYSTAL STRUCTURE OF GALACTOSYLTRANSFERASE LGTC IN COMPLEX WITH MN AND UDP-2F-GALACTOSE
Descriptor:GLYCOSYL TRANSFERASE, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUOROGALACTOSE, ...
Authors:Persson, K., Hoa, D.L., Diekelmann, M., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Deposit date:2000-11-27
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
Nat.Struct.Biol., 8, 2001
1GA8
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CRYSTAL STRUCTURE OF GALACOSYLTRANSFERASE LGTC IN COMPLEX WITH DONOR AND ACCEPTOR SUGAR ANALOGS.
Descriptor:GALACTOSYL TRANSFERASE LGTC, 4-DEOXYLACTOSE, MANGANESE (II) ION, ...
Authors:Persson, K., Ly, H.D., Diekelmann, M., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Deposit date:2000-11-29
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
Nat.Struct.Biol., 8, 2001
1GVY
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SUBSTRATE DISTORSION BY BETA-MANNANASE FROM PSEUDOMONAS CELLULOSA
Descriptor:MANNAN ENDO-1,4-BETA-MANNOSIDASE, DINITROPHENYLENE, ZINC ION, ...
Authors:Ducros, V., Zechel, D.L., Gilbert, H.J., Szabo, L., Withers, S.G., Davies, G.J.
Deposit date:2002-02-28
Release date:2002-09-05
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Substrate Distortion by a Beta-Mannanase: Snapshots of the Michaelis and Covalent-Intermediate Complexes Suggest a B2,5 Conformation for the Transition State
Angew.Chem.Int.Ed.Engl., 41, 2002
1GW1
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SUBSTRATE DISTORTION BY BETA-MANNANASE FROM PSEUDOMONAS CELLULOSA
Descriptor:MANNAN ENDO-1,4-BETA-MANNOSIDASE, ZINC ION, SODIUM ION, ...
Authors:Ducros, V., Zechel, D.L., Gilbert, H.J., Szabo, L., Withers, S.G., Davies, G.J.
Deposit date:2002-03-01
Release date:2002-09-05
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Substrate Distortion by a Beta-Mannanase: Snapshots of the Michaelis and Covalent-Intermediate Complexes Suggest a B2,5 Conformation for the Transition State
Angew.Chem.Int.Ed.Engl., 41, 2002
1H6M
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COVALENT GLYCOSYL-ENZYME INTERMEDIATE OF HEN EGG WHITE LYSOZYME
Descriptor:LYSOZYME C, SODIUM ION, 2-deoxy-2-fluoro-alpha-D-glucopyranose, ...
Authors:Vocadlo, D.J., Davies, G.J., Laine, R., Withers, S.G.
Deposit date:2001-06-19
Release date:2001-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Catalysis by Hen Egg-White Lysozyme Proceeds Via a Covalent Intermediate
Nature, 412, 2001
1HV1
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DISSECTING ELECTROSTATIC INTERACTIONS AND THE PH-DEPENDENT ACTIVITY OF A FAMILY 11 GLYCOSIDASE
Descriptor:ENDO-1,4-BETA-XYLANASE
Authors:Joshi, M.D., Sidhu, G., Nielsen, J.E., Brayer, G.D., Withers, S.G., McIntosh, L.P.
Deposit date:2001-01-05
Release date:2001-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
Biochemistry, 40, 2001
1J01
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED INHIBITOR ISOFAGOMINE LACTAM
Descriptor:beta-1,4-xylanase, 3-HYDROXY-4-(3,4,5-TRIHYDROXY-TETRAHYDRO-PYRAN-2-YLOXY)-PIPERIDIN-2-ONE
Authors:Williams, S.J., Notenboom, V., Wicki, J., Rose, D.R., Withers, S.G.
Deposit date:2002-10-25
Release date:2002-11-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A New, Simple, High-Affinity Glycosidase Inhibitor: Analysis of Binding through X-ray Crystallography, Mutagenesis, and Kinetic Analysis
J.Am.Chem.Soc., 122, 2000
1JZ2
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E. COLI (LACZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC)
Descriptor:Beta-Galactosidase, 2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE, MAGNESIUM ION, ...
Authors:Juers, D.H., McCarter, J.D., Mackenzie, L., Withers, S.G., Matthews, B.W.
Deposit date:2001-09-13
Release date:2001-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
1KB3
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THREE DIMENSIONAL STRUCTURE ANALYSIS OF THE R195A VARIANT OF HUMAN PANCREATIC ALPHA AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Numao, S., Maurus, R., Sidhu, G., Wang, Y., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-05
Release date:2002-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
Biochemistry, 41, 2002
1KBB
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MECHANISTIC ANALYSES OF CATALYSIS IN HUMAN PANCREATIC ALPHA-AMYLASE: DETAILED KINETIC AND STRUCTURAL STUDIES OF MUTANTS OF THREE CONSERVED CARBOXYLIC ACIDS
Descriptor:ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ...
Authors:Rydberg, E.H., Li, C., Maurus, R., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-05
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Biochemistry, 41, 2002
1KBK
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MECHANISTIC ANALYSES OF CATALYSIS IN HUMAN PANCREATIC ALPHA-AMYLASE: DETAILED KINETIC AND STRUCTURAL STUDIES OF MUTANTS OF THREE CONSERVED CARBOXYLIC ACIDS
Descriptor:ALPHA-AMYLASE, PANCREATIC, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Rydberg, E.H., Li, C., Maurus, R., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-06
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Biochemistry, 41, 2002
1KGU
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THREE DIMENSIONAL STRUCTURE ANALYSIS OF THE R337A VARIANT OF HUMAN PANCREATIC ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, CALCIUM ION
Authors:Numao, S., Maurus, R., Sidhu, G., Wang, Y., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-28
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
Biochemistry, 41, 2002
1KGW
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THREE DIMENSIONAL STRUCTURE ANALYSIS OF THE R337Q VARIANT OF HUMAN PANCREATIC ALPHA-MYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Numao, S., Maurus, R., Sidhu, G., Wang, Y., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-28
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
Biochemistry, 41, 2002
1KGX
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THREE DIMENSIONAL STRUCTURE ANALYSIS OF THE R195Q VARIANT OF HUMAN PANCREATIC ALPHA AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Numao, S., Maurus, R., Sidhu, G., Wang, Y., Overall, C.M., Brayer, G.D., Withers, S.G.
Deposit date:2001-11-28
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
Biochemistry, 41, 2002
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