Author results

2HGF
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HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:HEPATOCYTE GROWTH FACTOR
Authors:Zhou, H., Mazzulla, M.J., Kaufman, J.D., Stahl, S.J., Wingfield, P.T., Rubin, J.S., Bottaro, D.P., Byrd, R.A.
Deposit date:1997-12-18
Release date:1998-06-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
Structure, 6, 1998
2NEF
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HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES
Descriptor:NEGATIVE FACTOR (F-PROTEIN)
Authors:Grzesiek, S., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.S., Kaufman, J., Palmer, I., Stahl, S.J., Tjandra, N., Wingfield, P.T.
Deposit date:1997-02-12
Release date:1997-07-07
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Refined solution structure and backbone dynamics of HIV-1 Nef.
Protein Sci., 6, 1997
2X7L
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IMPLICATIONS OF THE HIV-1 REV DIMER STRUCTURE AT 3.2A RESOLUTION FOR MULTIMERIC BINDING TO THE REV RESPONSE ELEMENT
Descriptor:FAB HEAVY CHAIN, FAB LIGHT CHAIN, PROTEIN REV
Authors:DiMattia, M.A., Watts, N.R., Stahl, S.J., Rader, C., Wingfield, P.T., Stuart, D.I., Steven, A.C., Grimes, J.M.
Deposit date:2010-03-01
Release date:2010-03-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Implications of the HIV-1 Rev Dimer Structure at 3. 2 A Resolution for Multimeric Binding to the Rev Response Element.
Proc.Natl.Acad.Sci.USA, 107, 2010
1EY1
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SOLUTION STRUCTURE OF ESCHERICHIA COLI NUSB
Descriptor:ANTITERMINATION FACTOR NUSB
Authors:Altieri, A.S., Mazzulla, M.J., Horita, D.A., Coats, R.H., Wingfield, P.T.
Deposit date:2000-05-05
Release date:2000-06-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the transcriptional antiterminator NusB from Escherichia coli.
Nat.Struct.Biol., 7, 2000
1QBZ
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THE CRYSTAL STRUCTURE OF THE SIV GP41 ECTODOMAIN AT 1.47 A
Descriptor:PROTEIN (SIV GP41 ECTODOMAIN), MERCURY (II) ION, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Yang, Z.-N., Mueser, T.C., Kaufman, J., Stahl, S.J., Wingfield, P.T., Hyde, C.C.
Deposit date:1999-04-28
Release date:1999-05-17
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The crystal structure of the SIV gp41 ectodomain at 1.47 A resolution.
J.Struct.Biol., 126, 1999
2ARI
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SOLUTION STRUCTURE OF MICELLE-BOUND FUSION DOMAIN OF HIV-1 GP41
Descriptor:Envelope polyprotein GP160
Authors:Jaroniec, C.P., Kaufman, J.D., Stahl, S.J., Viard, M., Blumenthal, R., Wingfield, P.T., Bax, A.
Deposit date:2005-08-19
Release date:2005-12-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Dynamics of Micelle-Associated Human Immunodeficiency Virus gp41 Fusion Domain.
Biochemistry, 44, 2005
3V6F
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CRYSTAL STRUCTURE OF AN ANTI-HBV E-ANTIGEN MONOCLONAL FAB FRAGMENT (E6), UNBOUND
Descriptor:Fab e6 Heavy Chain, Fab e6 Light Chain
Authors:Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.
Deposit date:2011-12-19
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure, 21, 2013
3V6Z
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CRYSTAL STRUCTURE OF HEPATITIS B VIRUS E-ANTIGEN
Descriptor:Fab e6 Heavy Chain, Fab e6 Light Chain, e-antigen
Authors:Dimattia, M.A., Watts, N.R., Stahl, S.J., Grimes, J.M., Steven, A.C., Stuart, D.I., Wingfield, P.T.
Deposit date:2011-12-20
Release date:2013-02-06
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
Structure, 21, 2013
4HLA
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CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR
Descriptor:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Yedidi, R.S., Garimella, H., Palmer, I., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2012-10-16
Release date:2013-07-24
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Antimicrob.Agents Chemother., 57, 2013
4I8W
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CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL007
Descriptor:Protease, 4-{[(2R,3S)-3-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-2-hydroxy-4-phenylbutyl](2-methylpropyl)sulfamoyl}benzoic acid
Authors:Yedidi, R.S., Palmer, I., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2012-12-04
Release date:2013-07-24
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Antimicrob.Agents Chemother., 57, 2013
4I8Z
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CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL008
Descriptor:Protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
Authors:Yedidi, R.S., Palmer, I., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2012-12-04
Release date:2013-07-24
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Antimicrob.Agents Chemother., 57, 2013
4NJS
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL008
Descriptor:Protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
Authors:Yedidi, R.S., Garimella, H., Kaufman, J.D., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2013-11-11
Release date:2014-04-02
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
4NJT
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR
Descriptor:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
Authors:Yedidi, R.S., Garimella, H., Chang, S.B., Kaufman, J.D., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2013-11-11
Release date:2014-04-02
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
4NJU
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH TIPRANAVIR
Descriptor:Protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
Authors:Yedidi, R.S., Garimella, H., Kaufman, J.D., Das, D., Wingfield, P.T., Mitsuya, H.
Deposit date:2013-11-11
Release date:2014-04-02
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
4NJV
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH RITONAVIR
Descriptor:Protease, RITONAVIR
Authors:Yedidi, R.S., Garimella, H., Chang, S.B., Kaufman, J.D., Das, D., Wingfield, P.T., Mitsuya, H.
Deposit date:2013-11-11
Release date:2014-04-02
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Antimicrob.Agents Chemother., 58, 2014
4RVI
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL0519
Descriptor:HIV-1 protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate
Authors:Yedidi, R.S., Garimella, H., Kaufman, J.D., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2014-11-26
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1
To be Published
4RVJ
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH AMPRENAVIR
Descriptor:HIV-1 protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER
Authors:Yedidi, R.S., Garimella, H., Kaufman, J.D., Das, D., Wingfield, P.T., Mitsuya, H.
Deposit date:2014-11-26
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1
To be Published
4RVX
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CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL079
Descriptor:HIV-1 Protease, (4S)-4-amino-N-[(2S,3S)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3,4-dihydro-2H-chromene-6-carboxamide
Authors:Yedidi, R.S., Garimella, H., Kaufman, J.D., Das, D., Wingfield, P.T., Ghosh, A.K., Mitsuya, H.
Deposit date:2014-11-28
Release date:2016-05-04
Method:X-RAY DIFFRACTION (1.955 Å)
Cite:Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1.
To be Published
5DHV
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HIV-1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES
Descriptor:Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ...
Authors:DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C.
Deposit date:2015-08-31
Release date:2016-06-22
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.
Structure, 24, 2016
5DHX
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HIV-1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES
Descriptor:Anti-Rev Antibody Fab single-chain variable fragment, light chain,Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, ...
Authors:DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C.
Deposit date:2015-08-31
Release date:2016-06-22
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.
Structure, 24, 2016
5DHY
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HIV-1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES
Descriptor:Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ...
Authors:DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C.
Deposit date:2015-08-31
Release date:2016-06-22
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.
Structure, 24, 2016
5DHZ
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HIV-1 REV NTD DIMERS WITH VARIABLE CROSSING ANGLES
Descriptor:Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ...
Authors:DiMattia, M.A., Watts, N.R., Wingfield, P.T., Grimes, J.M., Stuart, D.I., Steven, A.C.
Deposit date:2015-08-31
Release date:2016-06-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.
Structure, 24, 2016
6BSY
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HIV-1 REV ASSEMBLY DOMAIN (RESIDUES 1-69)
Descriptor:Protein Rev, PHOSPHATE ION
Authors:Watts, N.R., Eren, E., Zhuang, X., Wang, Y.X., Steven, A.C., Wingfield, P.T.
Deposit date:2017-12-04
Release date:2018-04-11
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.
J. Struct. Biol., 203, 2018
6CF2
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CRYSTAL STRUCTURE OF HIV-1 REV (RESIDUES 1-93)-RNA APTAMER COMPLEX
Descriptor:Anti-Rev Antibody, heavy chain, light chain, ...
Authors:Eren, E., Dearborn, A.D., Wingfield, P.T.
Deposit date:2018-02-13
Release date:2018-07-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association.
Structure, 26, 2018
6CVK
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HEPATITIS B E-ANTIGEN IN COMPLEX WITH SCFV E13
Descriptor:Single chain variable fragment (scFv) e13, Capsid protein
Authors:Eren, E., Steven, A.C., Wingfield, P.T.
Deposit date:2018-03-28
Release date:2018-08-29
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.
Structure, 26, 2018
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