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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Descriptor:	3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride, Eukaryotic translation initiation factor 4E
Authors:	Wan, X.B, Shoichet, B.K, Taunton, J.
Deposit date:	2019-08-13
Release date:	2019-10-23
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. J.Am.Chem.Soc., 142, 2020

Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Descriptor:	3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride, Eukaryotic translation initiation factor 4E
Authors:	Wan, X.B, Shoichet, B.K, Taunton, J.
Deposit date:	2019-08-13
Release date:	2019-10-16
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. J.Am.Chem.Soc., 142, 2020

Reversible lysine-targeted probes reveal residence time-based kinase selectivity in vivo
Descriptor:	6-[(5-cyclopropyl-1~{H}-pyrazol-3-yl)amino]-2-[4-[(3-methyl-4-oxidanyl-phenyl)methyl]piperazin-1-yl]-~{N}-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A, CHLORIDE ION
Authors:	Craven, G.B, Wan, X.B, Taunton, J.
Deposit date:	2021-07-31
Release date:	2022-06-08
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nat.Chem.Biol., 18, 2022