Author results

8A3H
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CELLOBIOSE-DERIVED IMIDAZOLE COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS AT 0.97 A RESOLUTION
分子名称:PROTEIN (ENDOGLUCANASE), SULFATE ION, ACETATE ION, ...
著者Varrot, A., Schulein, M., Pipelier, M., Vasella, A., Davies, G.J.
登録日1999-01-20
公開日2000-01-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (0.97 Å)
主引用文献Lateral Protonation of a Glycosidase Inhibitor. Structure of the Bacillus agaradhaerens Cel5A in Complex with a Cellobiose-Derived Imidazole at 0.97 A Resolution
J.Am.Chem.Soc., 121, 1999
6O97
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PROPYLAMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.75A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Matsushita, T., Sati, G.C., Kondasinghe, N., Pirrone, M.G., Kato, T., Waduge, P., Kumar, H.S., Sanchon, A.C., Dobosz-Bartoszek, M., Shcherbakov, D., Juhas, M., Hobbie, S.N., Schrepfer, T., Chow, C.S., Polikanov, Y.S., Schacht, J., Vasella, A., Bottger, E.C., Crich, D.
登録日2019-03-13
公開日2019-04-17
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J. Am. Chem. Soc., 141, 2019
4V45
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E. COLI (LACZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE
分子名称:Beta-Galactosidase, 2-FLUORO-2-DEOXY-BETA-D-GALACTOPYRANOSE, MAGNESIUM ION, ...
著者Juers, D.H., McCarter, J.D., Withers, S.G., Matthews, B.W.
登録日2001-09-13
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4V44
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E. COLI (LACZ) BETA-GALACTOSIDASE IN COMPLEX WITH 2-F-LACTOSE
分子名称:Beta-Galactosidase, 2-FLUORO-2-DEOXY-LACTOSE, MAGNESIUM ION, ...
著者Juers, D.H., McCarter, J.D., Withers, S.G., Matthews, B.W.
登録日2001-09-13
公開日2014-07-09
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4B3T
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 39
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3S
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 37
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3R
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 30
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-26
公開日2013-08-07
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3M
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 1
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
登録日2012-07-25
公開日2013-08-07
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4AQY
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STRUCTURE OF RIBOSOME-APRAMYCIN COMPLEXES
分子名称:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
著者Matt, T., Ng, C.L., Lang, K., Sha, S.H., Akbergenov, R., Shcherbakov, D., Meyer, M., Duscha, S., Xie, J., Dubbaka, S.R., Perez-Fernandez, D., Vasella, A., Ramakrishnan, V., Schacht, J., Bottger, E.C.
登録日2012-04-20
公開日2012-07-18
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Dissociation of Antibacterial Activity and Aminoglycoside Ototoxicity in the 4-Monosubstituted 2-Deoxystreptamine Apramycin.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SIL
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SIALIDASE FROM SALMONELLA TYPHIMURIUM
分子名称:SIALIDASE, POTASSIUM ION, PHOSPHATE ION, ...
著者Garman, E.F., Sheldrick, G.M.
登録日1998-07-07
公開日1998-11-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献An Enzyme at Atomic Resolution: The 1.05 A Structure of Salmonella Typhimurium Neuraminidase (Sialidase)
To be Published
3HSU
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FUNCTIONAL ROLES OF THE 6-S-CYSTEINYL, 8 ALPHA-N1-HISTIDYL FAD IN GLUCOOLIGOSACCHARIDE OXIDASE FROM ACREMONIUM STRICTUM
分子名称:Glucooligosaccharide oxidase, N-ACETYL-D-GLUCOSAMINE, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Liaw, S.-H., Huang, C.-H.
登録日2009-06-10
公開日2009-06-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Functional roles of the 6-S-cysteinyl, 8alpha-N1-histidyl FAD in glucooligosaccharide oxidase from Acremonium strictum
J.Biol.Chem., 283, 2008
2VR4
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TRANSITION-STATE MIMICRY IN MANNOSIDE HYDROLYSIS: CHARACTERISATION OF TWENTY SIX INHIBITORS AND INSIGHT INTO BINDING FROM LINEAR FREE ENERGY RELATIONSHIPS AND 3-D STRUCTURE
分子名称:BETA-MANNOSIDASE, (2Z,3R,4S,5R,6R)-2-[(4-aminobutyl)imino]-6-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-25
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQU
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, 1,2-ETHANEDIOL, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-18
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VQT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (2Z,3R,4S,5R,6R)-2-[(2-aminoethyl)imino]-6-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-03-18
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VOT
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (5R,6R,7S,8R)-6,7,8-trihydroxy-5-(hydroxymethyl)-2-[(phenylamino)methyl]-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium, 1,2-ETHANEDIOL, ...
著者Tailford, L.N., Offen, W.A., Smith, N., Dumon, C., Moreland, C., Gratien, J., Heck, M.-P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-02-20
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VO5
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (1R,4R,5R,7R,8R)-2-Benzyl-5-hydroxymethyl-2-aza-bicyclo[2.2.2]octane-4,7,8-triol, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-02-08
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VMF
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-01-25
公開日2008-04-01
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VL4
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2008-01-08
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2VJX
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STRUCTURAL AND BIOCHEMICAL EVIDENCE FOR A BOAT-LIKE TRANSITION STATE IN BETA-MANNOSIDASES
分子名称:BETA-MANNOSIDASE, (3S,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-2-ONE, 1,2-ETHANEDIOL, ...
著者Tailford, L.E., Offen, W.A., Smith, N.L., Dumon, C., Moreland, C., Gratien, J., Heck, M.P., Stick, R.V., Bleriot, Y., Vasella, A., Gilbert, H.J., Davies, G.J.
登録日2007-12-14
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and Biochemical Evidence for a Boat-Like Transition State in Beta-Mannosidases.
Nat.Chem.Biol., 4, 2008
2SIM
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THE STRUCTURES OF SALMONELLA TYPHIMURIUM LT2 NEURAMINIDASE AND ITS COMPLEX WITH A TRANSITION STATE ANALOGUE AT 1.6 ANGSTROMS RESOLUTION
分子名称:SIALIDASE, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
著者Taylor, G.L., Crennell, S.J., Garman, E.F., Vimr, E.R., Laver, W.G.
登録日1994-07-15
公開日1994-11-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
2SIL
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THE STRUCTURES OF SALMONELLA TYPHIMURIUM LT2 NEURAMINIDASE AND ITS COMPLEX WITH A TRANSITION STATE ANALOGUE AT 1.6 ANGSTROMS RESOLUTION
分子名称:SIALIDASE
著者Taylor, G.L., Crennell, S.J., Garman, E.F., Vimr, E.R., Laver, W.G.
登録日1994-07-13
公開日1994-08-31
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
J.Mol.Biol., 259, 1996
2OYM
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ENDO-GLYCOCERAMIDASE II FROM RHODOCOCCUS SP.: FIVE-MEMBERED IMINOCYCLITOL COMPLEX
分子名称:Endoglycoceramidase II, SODIUM ION, N-{[(2R,3R,4R,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)PYRROLIDIN-2-YL]METHYL}-4-(DIMETHYLAMINO)BENZAMIDE
著者Caines, M.E.C., Strynadka, N.C.J.
登録日2007-02-22
公開日2007-03-06
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Angew.Chem.Int.Ed.Engl., 46, 2007
2OYL
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ENDO-GLYCOCERAMIDASE II FROM RHODOCOCCUS SP.: CELLOBIOSE-LIKE IMIDAZOLE COMPLEX
分子名称:Endoglycoceramidase II, SODIUM ION, 5-HYDROXYMETHYL-5,6,7,8-TETRAHYDRO-IMIDAZO[1,2-A]PYRIDIN-6YL-7,8-DIOL-GLUCOPYRANOSIDE, ...
著者Caines, M.E.C., Strynadka, N.C.J.
登録日2007-02-22
公開日2007-03-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Angew.Chem.Int.Ed.Engl., 46, 2007
2OYK
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ENDO-GLYCOCERAMIDASE II FROM RHODOCOCCUS SP.: CELLOBIOSE-LIKE ISOFAGOMINE COMPLEX
分子名称:Endoglycoceramidase II, SODIUM ION, (3R,4R,5R)-3-HYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-4-YL BETA-D-GLUCOPYRANOSIDE, ...
著者Caines, M.E.C., Strynadka, N.C.J.
登録日2007-02-22
公開日2007-03-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.
Angew.Chem.Int.Ed.Engl., 46, 2007
2J7H
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BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH AZAFAGOMINE
分子名称:BETA-GLUCOSIDASE A, AZAFAGOMINE, CALCIUM ION, ...
著者Gloster, T.M., Meloncelli, P., Stick, R.V., Zechel, D., Davies, G.J.
登録日2006-10-08
公開日2006-10-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
J.Am.Chem.Soc., 129, 2007