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6E40
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEXED WITH FERRIC HEME AND EPACADOSTAT
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E41
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND AN EPACADOSTAT ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]sulfanyl}-1,2,5-oxadiazole-3-carboximidamide
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E42
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERRIC HEME AND 4-CHLOROPHENYL IMIDAZOLE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-(3-chlorophenyl)-1H-imidazole, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E43
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH A BMS-978587 ANALOG
Descriptor:Indoleamine 2,3-dioxygenase 1, (1R,2S)-2-(4-[cyclohexyl(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, BENZOIC ACID
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.705 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E44
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERRIC STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, PHOSPHATE ION
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E45
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) FREE ENZYME IN THE FERROUS STATE
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6E46
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CRYSTAL STRUCTURE OF HUMAN INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IN COMPLEX WITH FERROUS HEME AND TRYPTOPHAN
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, ...
Authors:Luo, S., Tong, L.
Deposit date:2018-07-16
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6MIW
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WWE DOMAIN OF HUMAN HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Halabelian, L., Loppnau, P., Tempel, W., Wong, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-09-20
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:WWE domain of human HUWE1
To Be Published
5YYL
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STRUCTURE OF MAJOR ROYAL JELLY PROTEIN 1 OLIGOMER
Descriptor:Major royal jelly protein 1, Apisimin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tian, W., Chen, Z.
Deposit date:2017-12-10
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun, 9, 2018
5WCH
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN USP9X
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CVZ
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CRYSTAL STRUCTURE OF THE WD40-REPEAT OF RFWD3
Descriptor:E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION
Authors:DONG, A., LOPPNAU, P., SEITOVA, A., HUTCHINSON, A., TEMPEL, W., WEI, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the WD40-repeat of RFWD3
to be published
6D0S
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RABGAP DOMAIN OF HUMAN TBC1D22B
Descriptor:TBC1 domain family member 22B, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-10
Release date:2018-06-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RabGAP domain of human TBC1D22B
To be Published
5ULO
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CRYSTAL STRUCTURE OF 14-3-3 ZETA IN COMPLEX WITH A SERINE 124-PHOSPHORYLATED TBC1D7 PEPTIDE
Descriptor:14-3-3 protein zeta/delta, TBC1 domain family member 7, 1,2-ETHANEDIOL, ...
Authors:DONG, A., HU, J., MADIGAN, J., WALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
6BY9
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CRYSTAL STRUCTURE OF EHMT1
Descriptor:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
Authors:Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of EHMT1
to be published
5WRV
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COMPLEX STRUCTURE OF HUMAN SRP72/SRP68
Descriptor:Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72, ACETATE ION, ...
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5WRW
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STRUCTURE OF HUMAN APO-SRP72
Descriptor:Signal recognition particle subunit SRP72, SULFATE ION
Authors:Gao, Y., Chen, Z.
Deposit date:2016-12-04
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation
J Mol Cell Biol, 9, 2017
5VBT
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CRYSTAL STRUCTURE OF A HIGHLY SPECIFIC AND POTENT USP7 UBIQUITIN VARIANT INHIBITOR
Descriptor:UBH04
Authors:DONG, A., DONG, X., LIU, L., GUO, Y., LI, Y., ZHANG, W., WALKER, J.R., SIDHU, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-03-30
Release date:2017-06-07
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published
5VBD
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CRYSTAL STRUCTURE OF A PUTATIVE UBL DOMAIN OF USP9X
Descriptor:USP9X, UNKNOWN ATOM OR ION
Authors:Dong, A., Chern, Y., Hou, F., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-03-29
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a putative UBL domain of USP9X
to be published
5TF2
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CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN
Descriptor:Prolactin regulatory element-binding protein, UNKNOWN ATOM OR ION
Authors:Walker, J.R., Zhang, Q., Dong, A., Wernimont, A., Li, Y., He, H., Tempel, W., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Chen, Z., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-09-23
Release date:2016-11-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
To be published
5JJW
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3 IN COMPLEX WITH USP15 DUSP-UBL DOMAIN
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, Ubiquitin carboxyl-terminal hydrolase 15, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
5JJX
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CRYSTAL STRUCTURE OF THE HAT DOMAIN OF SART3
Descriptor:Squamous cell carcinoma antigen recognized by T-cells 3, CHLORIDE ION, UNKNOWN ATOM OR ION
Authors:DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the HAT domain of sart3
to be published
5C7J
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CRYSTAL STRUCTURE OF NEDD4 WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase NEDD4, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5C7M
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CRYSTAL STRUCTURE OF E3 LIGASE ITCH WITH A UB VARIANT
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, Polyubiquitin-C
Authors:Walker, J.R., Hu, J., Dong, A., Wernimont, A., Zhang, W., Sidhu, S., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2015-06-24
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPK
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: NEDD4L AND UBV NL.1
Descriptor:E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P., Mukherjee, M., Mercredi, P.Y., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPL
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SYSTEM-WIDE MODULATION OF HECT E3 LIGASES WITH SELECTIVE UBIQUITIN VARIANT PROBES: RSP5 AND UBV R5.4
Descriptor:Rsp5, Ubiquitin variant R5.4
Authors:Wu, K.-P., Kamadurai, H.B., Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016